Growth and development of the cranial base in mice that spontaneously develop anterior transverse crossbite

Tsukamoto, Yuri; Kajii, Takashi S.; Oonishi, Yasutomo; Sugawara-Kato, Yuki; Hirabayashi, Yoshifumi; Iida, Junichiro

doi:10.1016/j.ajodo.2006.08.025

Cited by 8 publications

(11 citation statements)

References 20 publications

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“…Other factors to be considered are the strain‐specific characteristics of mice. The genetic background of some strains may modify the phenotype resulting from a mutation . Moreover, some strains may display a distinctive craniofacial characteristic.…”

Section: Discussionmentioning

confidence: 99%

Mouse models for the study of cranial base growth and anomalies

Vora

2017

Orthod Craniofacial Res

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The cranial base is a central and integral component of the cranioskeleton, yet little is known about its growth. Despite the dissimilarities between human and murine cranioskeletal form, mouse models are proving instrumental in studying craniofacial growth. The objectives of this review are to summarize recent findings from numerous mouse models that display growth defects in one or more cranial base synchondroses, with accompanying changes in chondrocyte cellular zones. Many of these models also display altered growth of the cranial vault and/or the facial region. FGFR, PTHrP, Ihh, BMP and Wnt/β-catenin, as well as components of primary cilia, are the major genes and signalling pathways identified in cranial base synchondroses. Together, these models are helping to uncover specific genetic influences and signalling pathways operational at the cranial base synchondroses. Many of these genes are in common with those of importance in the cranial vault and the facial skeleton, emphasizing the molecular integration of growth between the cranial base and other cranial regions. Selected models are also being utilized in testing therapeutic agents to correct defective craniofacial and cranial base growth.

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Section: Discussionmentioning

confidence: 99%

Mouse models for the study of cranial base growth and anomalies

Vora

2017

Orthod Craniofacial Res

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“…It was histologically shown that undersulphated GAGs cause a disturbance of endochondral growth at the cranial base with synchondrodial joints in bm / bm mice (5). In this study, 3D‐CT images showed that the cranial base of bm / bm mice was significantly smaller than that of control mice.…”

Section: Discussionmentioning

confidence: 99%

“…BALB/c‐ bm / bm mice (1) have a brachymorphic ( bm ) gene (2, 3) and various characteristics including a dome‐shaped skull, short thick tail, and shortened but not widened limbs (4, 5). The most remarkable feature in the craniofacial region is a spontaneous malocclusion (incisal transverse crossbite) (5). Malocclusion occurs in about 10% of BALB/c‐ bm / bm mice (5).…”

Section: Introductionmentioning

confidence: 99%

“…The most remarkable feature in the craniofacial region is a spontaneous malocclusion (incisal transverse crossbite) (5). Malocclusion occurs in about 10% of BALB/c‐ bm / bm mice (5). Malocclusion does not spontaneously occur in mice with the same bm mutation as that in C57BL‐ bm/bm mice and in non‐brachymorphic mice such as BALB/c‐+/+ mice and BALB/c‐ bm /+ ( bm heterozygotes) mice.…”

Section: Introductionmentioning

confidence: 99%

“…It was reported that columns of chondrocytes of BALB/c‐ bm / bm mice were irregularly arranged histologically and that undersulphated GAGs of the spheno‐occipital synchondrosis and intersphenoid synchondrosis might cause disturbed of endochondral growth at the cranial base (5). There were no significant differences in the concentrations of sulphated GAGs in condyles between mandibular shifted and non‐shifted sides in BALB/c‐ bm / bm mice with spontaneous malocclusion (10).…”

Section: Introductionmentioning

confidence: 99%

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