Relationship between degree of malocclusion and occlusal interference in mice that spontaneously develop anterior transverse crossbite

Morphological evaluation of cranial and maxillary shape differences of the brachymorphic mouse with spontaneous malocclusion using three‐dimensional micro‐computed tomography

“…BALB/c‐+/+ mice (control mice) were obtained from Nippon Clea (Tokyo, Japan). By outbreeding between bm mice of the C57BL strain and normal mice of the BALB/c strain, the bm gene was successfully transferred to BALB/c strain mice (BALB/c‐ bm /+ mice) (11). BALB/c‐ bm / bm mice were generated by crossbreeding between BALB/c‐ bm /+ mice.…”

“…In the experiment (11) using two‐dimensional headfilms, maxillary transverse deviation was found to be larger than mandibular deviation in BALB/c‐ bm / bm mice with malocclusion. However, no detailed information is available regarding the difference and the site.…”

“…After the incisors erupt, the malocclusion becomes more apparent. In the mice that had malocclusion, the degree of lateral deviation of maxillary and mandibular alveoli and incisor was milder if incisors were cut after malocclusion occurred (11). This showed that premature contact between the upper and lower incisors continuously induced occlusal force on the maxillary and mandibular alveoli and the load aggravated the malocclusion in the animal model.…”

Genetically programmed retinoic acid deficiency during gastrulation phenocopies most known developmental defects due to acute prenatal alcohol exposure in FASD

“…To further characterize the jaw, denture, and craniofacial phenotype of the Gsc +/Cyp26A1 mice and WT littermates were performed by µCT-based analysis and measurements. Gsc +/Cyp26A1 mice have pre-maxillary twisting resulting in misaligning of the maxillary and mandibular incisors, specifically an anterior transverse crossbite (Tsukamoto et al, 2010) (Figure 8). Premaxillary malocclusions occurred at equal rates to the left or right of cranium center and the malocclusions were never mandibular in origin.…”

Histological study of the nasal septal cartilage in BALB/c‐bm/bm mouse which spontaneously induces malocclusion

“…This means that an inherited feature of having bm homozygotes is a primary cause of malocclusion, and it is thought that a genetic factor is involved in the generation of malocclusion. On the other hand, the amount of lateral displacement of the maxillary alveolus and mandibular alveolus (lateral crossbite) was significantly decreased if the incisors were trimmed to eliminate occlusal interference just after anterior lateral crossbite had occurred (10), suggesting that environment factors are also involved in the generation of malocclusion.…”