Growing Impact of Carbohydrate‐Based Organocatalysts

Abstract

Organocatalysis has emerged as one of the most progressive and prevailing field of organic synthesis to assist green chemistry. Constantly increasing demand of promising scaffolds to develop potent organocatalysts has impelled researchers to utilize the unique traits of carbohydrate moiety in this field. Biological significance of carbohydrates, as well as, their high natural abundance as chiral non‐racemic material, presence of multiple hydroxyl groups, several stereogenic centres, and easily modifiable structure make this moiety an appropriate skeleton to develop organocatalysts to enhance productivity and selectivity of a chemical transformation. 21st Century has witnessed the progress of carbohydrate moiety in development of organocatalysts from obscurity to eminence. This review encapsulates the importance of carbohydrate scaffolds in organocatalysis mainly dealing with the synthesis and applications carbohydrate‐derived organocatalyst in different common organic reactions with their significance and future purspectives.

Synthetic Utility of N-Acylbenzotriazoles

“…Significant contributions were made by the Tiwari group towards the development of benzotriazole ring cleavage (BtRC) methodology. 117` j k l m n o In their first work, they accomplished the synthesis of benzoxazoles 270 from N -acylbenzotriazoles under heating condition in the presence of a Lewis acid using toluene as solvent. ; the reaction goes through a denitrogenative ring-opening process followed by cyclization (Scheme 90d ).…”

Design and synthesis of mixed-ligand architectured Zn-based coordination polymers for energy storage

“…and conducting polymers can deliver higher energy density and specific capacity by fast reversible redox reactions (faradaic process) occurring at the surface or near-surface of the electroactive materials. [6][7][8] However, their ultra-fast redox kinetics alters the intrinsic properties and de-stabilizes the porous structure, resulting in an inferior power density and low rate performance. 3 Currently, the paradigm has been shifted to integrate hybrid supercapacitors (HSCs) between two dissimilar electrode materials (faradaic and/or non-faradaic) through which the potential window can be maximized to achieve high capacitance and high energy/power densities.…”

“…Coordination polymers (CPs) and metal-organic frameworks (MOFs) comprise one-dimensional (1D), two-dimensional (2D) and three-dimensional (3D) porous polymeric structures consisting of metal ions/metal-oxo-clusters tethered by organic linkers through covalent/coordination interactions. 7,[9][10][11][12] These materials have gained widespread attention owing to their preternatural porosity, diverse functionality, structural modularity and good thermal stability. 13 These noticeable properties of MOFs/CPs have been explored in different fields, such as adsorption and separation, 14,15 energy storage and conversion, 7,16,17 water oxidation, 18 photo-luminescence 19 and sensing 20 to mention just a few.…”

“…7,[9][10][11][12] These materials have gained widespread attention owing to their preternatural porosity, diverse functionality, structural modularity and good thermal stability. 13 These noticeable properties of MOFs/CPs have been explored in different fields, such as adsorption and separation, 14,15 energy storage and conversion, 7,16,17 water oxidation, 18 photo-luminescence 19 and sensing 20 to mention just a few. Due to the existence of a vast number of organic linkers and/or metal nodes/clusters, great success has been achieved to incorporate diverse functionalities into MOFs/CPs through a simple isoreticular approach.…”

Pyridyl Glycosyl Triazole/CuI-Mediated Domino/Tandem Synthesis of Quinazolinones

“…Here, we have explored the application of carbohydrate-derived ligands in our study, moreover, to establish 4-hydroxy- l -proline-mediated catalysis. There are several salient features such as biorenewable, easy accessibility of the starting materials, cost effective, efficient functional group transformation, and chiral induction through the carbohydrate skeleton which is a well considered suitable moiety for the synthesis of ligands and organocatalysts. − The growing impact of sugar-derived ligands including glycosylated triazoles or triazole-appended glycohybrids in organic synthesis is well known. − Here, we developed novel pyridyl glycosyl triazoles using the Cu-catalyzed azide–alkyne cycloaddition (CuAAC) reaction − and report their high efficient catalytic activity with low loading using CuI in anhydrous DMF for an expeditious synthesis of biologically relevant 2-amino-3-substituted and 3-substituted quinazolinones under one-pot tandem reaction conditions.…”