Grouping all carbon nanotubes into a single substance category is scientifically unjustified

Fadeel, Bengt; Kostarelos, Kostas

doi:10.1038/s41565-020-0654-0

Cited by 68 publications

(55 citation statements)

References 17 publications

(10 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, it is noted that we have only studied one type of MWCNTs, and one cannot extrapolate the findings to other types of single or multi-walled CNTs. Indeed, grouping all CNTs into one material category is scientifically unjustified and may hinder innovation [ 57 , 58 ]. Therefore, further studies are needed to fully address the physicochemical properties that are responsible for the observed biological or toxicological effects of CNTs [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Profiling of Sub-Lethal in Vitro Effects of Multi-Walled Carbon Nanotubes Reveals Changes in Chemokines and Chemokine Receptors

et al. 2021

Self Cite

View full text Add to dashboard Cite

Engineered nanomaterials are potentially very useful for a variety of applications, but studies are needed to ascertain whether these materials pose a risk to human health. Here, we studied three benchmark nanomaterials (Ag nanoparticles, TiO2 nanoparticles, and multi-walled carbon nanotubes, MWCNTs) procured from the nanomaterial repository at the Joint Research Centre of the European Commission. Having established a sub-lethal concentration of these materials using two human cell lines representative of the immune system and the lungs, respectively, we performed RNA sequencing of the macrophage-like cell line after exposure for 6, 12, and 24 h. Downstream analysis of the transcriptomics data revealed significant effects on chemokine signaling pathways. CCR2 was identified as the most significantly upregulated gene in MWCNT-exposed cells. Using multiplex assays to evaluate cytokine and chemokine secretion, we could show significant effects of MWCNTs on several chemokines, including CCL2, a ligand of CCR2. The results demonstrate the importance of evaluating sub-lethal concentrations of nanomaterials in relevant target cells.

show abstract

Section: Discussionmentioning

confidence: 99%

Profiling of Sub-Lethal in Vitro Effects of Multi-Walled Carbon Nanotubes Reveals Changes in Chemokines and Chemokine Receptors

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…[196] Researchers working in the field for almost 20 years have recommended making modifications of the record by precisely defining the specific type of CNTs showing a clear evidence of toxicity. [197][198][199] CNTs are a diverse class of nanomaterials with various lengths, diameters, and morphologies. The generalization of research results obtained from a very narrow subset of data to make broad claims actually brings confusion.…”

Section: Discussionmentioning

confidence: 99%

Carbon Nanomaterials Applied for the Treatment of Inflammatory Diseases: Preclinical Evidence

Soltani

Guo

Bianco

et al. 2020

Advanced Therapeutics

View full text Add to dashboard Cite

In the last decade, graphene‐based nanomaterials and carbon dots have joined the family of carbon materials mainly composed of graphite, diamond, fullerene, and carbon nanotubes. Carbon nanomaterials have been widely exploited in various fields from electronics and materials science to nanomedicine. The studies on their effect on the immune system have revealed that they possess intrinsic anti‐inflammatory properties, reducing the production of proinflammatory cytokines and modulating immune cell maturation. In addition, their large specific surface area associated with high biocompatibility allows their use as carriers for the delivery of anti‐inflammatory agents. They can also contribute to the diagnosis of inflammatory diseases as biosensors for low‐limit detection and quantification of inflammation‐related biomarkers in body fluids and tissues allowing to monitor the concentration of drugs in urine and guide personalized drug usage. Finally, they are used as adsorbents for blood plasma purification in the clinical treatment of sepsis through efficient removal of certain cytokines. This review focuses on the intrinsic anti‐inflammatory properties of carbon nanomaterials. An overview is provided on their use as carriers of anti‐inflammatory drugs, as biosensors, and for blood purification in the context of inflammatory diseases. The potential of carbon nanomaterials for clinical translation is also critically discussed.

show abstract

“…The relationship between delivery of nanoparticles and issues surrounding the toxicity of particulate materials is clearly one of importance, raising the question whether nanomaterials “necessitate a new toxicological science” [ 38 ]. Carbon nanotubes have been considered to consist of a material which should be banned because of toxicity [ 39 ], but this has been rightly challenged on the grounds that not all carbon nanotubes are identical [ 40 ]. Generalisations are unscientific whether they refer to action, efficacy or toxicity.…”

Section: Considerations and Generalisationsmentioning

confidence: 99%

Trajectories in nanotechnology: embracing complexity, seeking analogies

Florence

2021

Drug Deliv. and Transl. Res.

View full text Add to dashboard Cite

This account comprises personal reflections on the field of nanosystems primarily designed for the delivery of biologically active agents. It emphasises the colloidal nature of nanoparticles obeying the same physical laws that dictate the behaviour of disperse systems. Research reveals not only intrinsic complexities but a variety of possible trajectories in vivo and ex vivo, issues of stability, interactions and behaviour in a range of often constrained environments. Such are the variations in the chemical and physical nature of the nanosystems and the active agents they carry, their putative “targets” and the many biological systems and models in which they are employed, it is not possible to generalise. Stochastic events may exclude precise prediction or extrapolation of outcomes, but embracing and studying complexity lead to new insights, often aided by consideration of analogies in cognate areas. This is part of the process of illumination. Unexpected results provide the true essence and excitement of scientific endeavour. Simplification is perhaps its antithesis.

show abstract

Grouping all carbon nanotubes into a single substance category is scientifically unjustified

Cited by 68 publications

References 17 publications

Profiling of Sub-Lethal in Vitro Effects of Multi-Walled Carbon Nanotubes Reveals Changes in Chemokines and Chemokine Receptors

Profiling of Sub-Lethal in Vitro Effects of Multi-Walled Carbon Nanotubes Reveals Changes in Chemokines and Chemokine Receptors

Carbon Nanomaterials Applied for the Treatment of Inflammatory Diseases: Preclinical Evidence

Trajectories in nanotechnology: embracing complexity, seeking analogies

Contact Info

Product

Resources

About