Group-specific component (Gc) polymorphism in Japanese: An investigation on the phenotypic distribution with regard to theGc
J allele

Kuwata, Mieko; Ishimoto, Goichi; Nakajima, Hachiro

doi:10.1007/bf02001793

Cited by 3 publications

(5 citation statements)

References 5 publications

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“…This proportion is compatible with the previous observation (rare phenotypes in 5.1~ out of 1,347 individuals) by immunoelectrophoresis (Kuwata et al, 1978). Furthermore, 4 variant alleles determined from the selected samples in the previous study were Table 3.…”

Section: Distribution Of Gc Subtypes In Japanese Populationsupporting

confidence: 91%

“…In the previous paper (Kuwata et al, 1978) we observed that a variant allele, Gc ~, attains to be a polymorphic frequency in Japanese populations. As mentioned in that paper, however, there were some cases in which it was somewhat difficult to distinguish the Gc J-1 from Gc 1-1 by agar gel immunoelectrophoresis used at that time.…”

Section: Introductionmentioning

confidence: 86%

“…The serum samples with Gc J phenotypes previously determined by immunoelectrophoresis (Kuwata et al, 1978) were examined first in order to discriminate the variants from common Gc phenotypes. They were stored for up to 3 years after the initial use.…”

Section: Methodsmentioning

confidence: 99%

“…In the previous study which was performed by prolonged immunoelectrophoresis (Kuwata et aL, 1978), we identified the phenotypes with Gc J in 69 out of 1,347 individuals. Among them, 52 samples were re-examined by the immunofixation isoelectric focusing, and it was found that the Gc J previously determined was subdivided into 4 different alleles.…”

Section: Heterogeneity Of the Gc Jmentioning

confidence: 99%

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Group-specific component (Gc) polymorphism in Japanese: An analysis by isoelectric focusing on polyacrylamide gels

1979

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Section: Distribution Of Gc Subtypes In Japanese Populationsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 86%

Section: Methodsmentioning

confidence: 99%

Section: Heterogeneity Of the Gc Jmentioning

confidence: 99%

See 2 more Smart Citations

Group-specific component (Gc) polymorphism in Japanese: An analysis by isoelectric focusing on polyacrylamide gels

1979

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“…Therefore, the alleles of Gc variants are distributed widely in Japanese. Kuwata et al (1978) examined Gc polymorphic frequency in Fukushima Prefecture using an agar gel immunoelectrophoresis, and estimated the Gc frequencies of Gc 1 0.7285, Gc 2 0.2463 and GcJ 0.0252. There is no significant difference between these values and the ones presented in our study, that is, GO 0.7256, Gc 2 0.2469 and Gc ~ 0.0276.…”

Section: Ge Systemmentioning

confidence: 99%

Genetic polymorphism of red cell enzymes (AcP, EsD, GPT, 6-PGD) and of serum protein(Gc) in Fukushima Prefecture

Abe

1983

Jap J Human Genet

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SummaryThe polymorphism of red cell enzymes (AcP, EsD, GPT and 6-PGD) and of serum protein (Gc) was examined in samples of unrelated individuals living in Fukushima Prefecture. Gc subtypes were determined by isoelectric focusing and immunofixation. It was found, in the formers, the gene frequencies of AcP A, EsD 1, GPT 1 and 6-PGD A to be 0.229, 0.634, 0.623 and 0.921, and in the latter, Gc 1F, Gd s, Gc ~ and Gc ~ to be 0.4854, 0.2402, 0.2469 and 0.0276, respectively. Two of rare phenotypic variants of Gc were also described.

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Ethnic variation in vitamin D-binding protein (GC): a review of isoelectric focusing studies in human populations

1986

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Since the discovery in 1977 that the GC1 gene could be resolved into two common subcomponents on an isoelectric focusing (IEF) gel, a large number of ethnic groups have been screened to analyze the extent of genetic variation in human populations. Using the IEF technique, approximately 50,000 individuals from 160 different populations have been tested for the GC polymorphism. A marked variation in common GC suballele frequencies in different geographic areas seems to correlate with skin pigmentation and intensity of sun light. Pigmented (black) and keratinized (yellowish) skin type populations have a relatively high frequency of the GC*IF allele as compared to white skin populations. By comparison non-pigmented and non-keratinized white skin populations are generally characterized by having the maximum values of the GC*IS allele. The anthropologic significance of the GC locus has been enhanced further by detecting additional unique GC variants which provide useful information about evolutionary links between different populations. However, the presence of some electrophoretically identical unique variants in genetically and geographically distinct populations demand further investigation of these allelic variants to shed more light on their origins.

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Group-specific component (Gc) polymorphism in Japanese: An investigation on the phenotypic distribution with regard to theGc J allele

Cited by 3 publications

References 5 publications

Group-specific component (Gc) polymorphism in Japanese: An analysis by isoelectric focusing on polyacrylamide gels

Group-specific component (Gc) polymorphism in Japanese: An analysis by isoelectric focusing on polyacrylamide gels

Genetic polymorphism of red cell enzymes (AcP, EsD, GPT, 6-PGD) and of serum protein(Gc) in Fukushima Prefecture

Ethnic variation in vitamin D-binding protein (GC): a review of isoelectric focusing studies in human populations

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