Group G Streptococcus Infective Endocarditis in Association With Colon Cancer

Abstract

Group G streptococcus has been increasingly reported as a cause of bacteremia and infective endocarditis. The association between various groups of streptococcus with malignancy has been well established. Such association is particularly observed in group D Streptococcus bovis which is commonly reported in association with carcinoma of the colon. We herein report a case of a 72-year-old male who presented with severe sepsis, iron deficiency anemia and newly diagnosed cardiac murmur. Further workup confirmed group G streptococcus bacteremia, infective endocarditis and newly diagnosed carcinoma of the colon. This case highlights a unique association between invasive form of group G streptococcus and colon cancer.

Effects of infections on the pathogenesis of cancer

“…Treatment of HP infection may reduce mucosal inflammation, DNA damage and cell turnover and improve gastric acid secretion in patients with previous hypochloridia 115 . The detection of high levels of HP DNA in liver biopsies of patients with liver chronic diseases, such as HCC, biliary cirrhosis and sclerosing cholangitis, suggested a promoting role of HP in hepatic carcinogenesis 116 .…”