Group B Streptococcus prophylaxis in patients who report a penicillin allergy: a follow-up study

Abstract

Conclusion-With directed intervention, adherence to the 2002 CDC guidelines for GBS prophylaxis in penicillin-allergic women improved dramatically.

Use of Cefazolin for Group B Streptococci Prophylaxis in Women Reporting a Penicillin Allergy Without Anaphylaxis

“…This is especially true with positive GBS bacteriuria results (58.2% of women with vaginal GBS colonization had testing performed compared with 28.0% of women with GBS bacteriuria). These findings are similar to those found by Critchfield et al 12 Strengths of this study include that it was performed at a large institution and is one of few studies that has looked specifically at GBS prophylaxis in women with a penicillin allergy without reported anaphylaxis.…”

“…20,21 A 2011 retrospective study performed at the same institution found that, after the implementation of interventions to improve adherence to the CDC guidelines, the proportion of GBS-colonized, penicillin-allergic women receiving appropriate antibiotics increased from 16.2% in 2004-2006 to 76% in 2008. 12 Our study found many fewer women received appropriate intrapartum antibiotic prophylaxis over a similar timeframe. This study by Critchfield et al, 12 however, looked at all women with a reported penicillin allergy and did not categorize women into high and low risk for anaphylaxis to penicillin.…”

“…12 Our study found many fewer women received appropriate intrapartum antibiotic prophylaxis over a similar timeframe. This study by Critchfield et al, 12 however, looked at all women with a reported penicillin allergy and did not categorize women into high and low risk for anaphylaxis to penicillin. They do note in their discussion that although they did not clearly determine which patients were high and low risk, they believed that cephalosporins were underutilized.…”

“…[4][5][6][7][8] Unfortunately, several studies have demonstrated that very few penicillinallergic women not at high risk for anaphylaxis receive cefazolin. [9][10][11][12] These studies were performed before the release of the most recent CDC guidelines.…”

Prevention of neonatal group B streptococcal sepsis in Hungary in 2012. Preliminary data of a nation-wide survey

“…Igazolódott, hogy az újszülöttek fertőzése úgy előzhető meg, ha a baktériumot hordozó terhes a szülés megindulása után legalább két alkalommal, négy óra különbséggel, intravénás penicillin-vagy ampicillinkezelésben részesül [2,3]. Alternatív antibiotikum adá-sára csak a penicillinallergiás terhesek szorulnak [4].…”