Group B Streptococcus Late-Onset Disease: 2003–2010

Abstract

Preterm neonates had the highest rates of LOD and mortality. Most mothers carried GBS at the time of the LOD diagnosis, whereas 6% had mastitis. Intrapartum antibiotics were associated both with delayed presentation of symptoms and milder LOD.

Incidence and Outcome of Group B Streptococcal Sepsis in Infants in Switzerland

“…Indeed, the incidence of GBS-EOS in our cohort is 2-to 4-fold lower than the incidence reported in other high-income countries, whereas the incidence of GBS-LOS is in the range of previous studies performed in other European countries, Australia and North America. 1,[4][5][6]8 The reason for a low incidence of GBS-EOS in Switzerland is unclear. National data on the rate of rectovaginal GBS carriage in pregnant women and IAP are not available in Switzerland.…”

“…Therefore, our study may underestimate the total burden of GBS invasive disease. 4,5,8 A second limitation is that the surveillance, which was based on the 10 main pediatric hospitals of Switzerland, may have missed some cases with milder clinical presentation that were treated in regional hospitals. However, because all neonatal and pediatric intensive care units of Switzerland participated in this study, we can assume that all severe cases were captured.…”

Neurological complications after neonatal bacteremia: The clinical characteristics, risk factors and outcomes

“…Although GBS is well known as the most important pathogen of neonatal early-onset sepsis, 80% (12/15) of our GBSrelated BNCs are late-onset sepsis and the majority (13/15, 86.7%) occurred in neonates with a gestational age of $33 weeks. A recent prospective report has found that term-born infants have more GBS late-onset sepsis and meningitis compared to preterm infants had [27], even though the incidence is relatively lower in term-born infants (0.24 and 1.4 per 1000 live births for term and preterm newborns, respectively). Given the substantial burden of late-onset GBS disease, an effective prevention strategy should be enforced to reduce maternal colonization and transmission [27,28].…”

Infeção tardia por Streptococcus do grupo B - uma manifestação em espelho em gémeos heterozigóticos

“…[2][3][4] A sua incidência varia de 0,27-1,4/1000 nados--vivos, sendo mais elevada nos prematuros. 1,2,5 Em Portugal tem-se verificado uma descida da incidên-cia global de sépsis por SGB comprovada nos primeiros três meses de vida, sendo de 0,6/1000 nados-vivos em 2002 e de 0,15/1000 nados-vivos em 2007. 6 Em 2008, um estudo realizado no Norte de Portugal identificou uma taxa de colonização de 18% em grávidas, 6 e em 2014 uma taxa de 16% foi descrita numa maternidade em Lisboa.…”