Group B streptococcus colonisation in pregnant women at Dr. George Mukhari Hospital, South Africa

Monyama, Maropeng Charles; Bolukaoto, John Y.; Chukwu, Martina O.; Maloba, Motlatji Reratilwe Bonnie; Moyo, Sylvester R.; Mavenyengwa, Rooyen T.; Nchabeleng, Maphoshane; Lebelo, Sogolo Lucky

doi:10.1080/23120053.2016.1156308

Cited by 9 publications

(17 citation statements)

References 27 publications

(16 reference statements)

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“…Lower GBS prevalence (3.2%) was reported from Argentina (22), Turkey (8.0%) (23), China (8.2%) (24), Mozambique (1.8%) (25), India (2.3%) (26), and Nigeria (10.7%) (27). The higher prevalence rates (25, 30, and 30.9%) reported in the other South African studies [(17–19), respectively], fall within the range reported from other parts of Africa such as 20.9% in Ethiopia (28), 23% in Tanzania (29), and 31.6% in Zimbabwe (30). Studies from Iran (31), Brazil (32), and Switzerland (33) also reported prevalence rates of 22.7, 24, and 21%, respectively.…”

Section: Discussionsupporting

confidence: 72%

“…In the present study, we followed the CDC guidelines (8) for sample collection and culture and found an overall GBS prevalence of 16.6%, compared with prevalence rates of 25, 30, and 30.9% reported in similar studies from South Africa (17–19). These differences may be attributed to several factors including ethnicity and socio-economic standards.…”

Section: Discussionsupporting

confidence: 55%

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Group B Streptococcus Serotypes in Pregnant Women From the Western Cape Region of South Africa

Africa

Kaambo

2018

Front. Public Health

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Background: Maternal colonization of Group B streptococci (GBS) during pregnancy is an important risk factor for neonatal morbidity and mortality. The aim of this study was to determine the prevalence and serotype distribution of GBS isolated from a cohort of pregnant women in the Western Cape, South Africa.Methods: Two ano-vaginal swabs were collected from 301 women at 28–37 weeks of gestation. Participants were recruited from four different antenatal clinics in the Western Cape, South Africa. GBS were detected by culture and PCR and serotypes confirmed by latex agglutination tests. Antibiotic sensitivity was performed using disc diffusion.Results: The GBS colonization rate was 16.6%. Serotype distribution revealed serotype V as the predominant serotype (66.67%) followed by serotype III (21.05%). Serotypes Ia, II, IV, and IX constituted 1.75% each and 3 GBS isolates were non-typeable. Serotype V demonstrated resistance to most of the antibiotics tested, while serotype III demonstrated better susceptibility, except for tetracycline. No significant differences were observed for GBS colonization or serotype distribution according to HIV status.Conclusion: Predominating serotypes differed from those previously reported from other regions in South Africa. Global surveillance of serotype distribution plays an important role in informing vaccine development and antibiotic prophylaxis.

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Section: Discussionsupporting

confidence: 72%

Section: Discussionsupporting

confidence: 55%

Group B Streptococcus Serotypes in Pregnant Women From the Western Cape Region of South Africa

Africa

Kaambo

2018

Front. Public Health

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“…On the basis of formal education level (see Table 3 ), the highest GBS colonization rate was found for ≤ Secondary Education Examination (29.63%). Similar studies conducted by Monyama et al [ 34 ] and Mengist et al [ 40 ] showed higher GBS colonization in lower matrix. This may be due to the lack of awareness in uneducated or illiterate groups.…”

Section: Discussionsupporting

confidence: 86%

“…In this study, the GBS rate was recorded slightly higher in medium aged women (see Table 3) than in other groups; a previous similar study reported higher rate in women with age 18-35 than in the younger [33]. In fact, sexual activity can be expected to be higher in medium age group as reproductive population which increases the risk of the GBS often being sexually transmitted [34].…”

Section: Discussionmentioning

confidence: 40%

Molecular Characterization of Streptococcus agalactiae Isolates from Pregnant Women in Kathmandu City

Shrestha¹,

Sah

Singh

et al. 2020

Journal of Tropical Medicine

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Introduction. Group B streptococci (GBS) are globally recognized as one of the leading causes of neonatal sepsis and meningitis and is also known to cause adverse pregnancy outcomes such as stillbirths and miscarriages. Thus, detailed investigation of GBS in pregnant women has special significance in public health related researches. Objectives. The present study is aimed at evaluating the prevalence of GBS colonization among pregnant women in Kathmandu city. Methods. The study was carried out among 125 pregnant women at their trimester (35–37 weeks) (during the time period between January and June in 2018). The prevalence was determined by the culture method in HiCrome Strep B Selective Agar Base and then by using the PCR technique. The serotypes were evaluated by multiplex PCR analysis, while the antibiotics susceptibility tests were performed using the disk diffusion method. Results. Among 125 samples studied, GBS were recorded in 24 samples (implying a prevalence of 19.2%). Furthermore, using the multiplex PCR, among 24 GBS-positive samples, 13 (54.17%) were found to be typeable while 11 (45.83%) were nontypeable. The most abundant serotype recorded in this study was type III (33.33) while the serotypes IV, V, VI, VII, and VIII were not found. Conclusion. The isolates were sensitive towards some antibiotics such as linezolid and ceftriaxone 100%, whereas penicillin 50% and vancomycin 75% but were resistant to tetracycline and ertapenem. Serotype III was found to be predominant in the samples collected during the study period. The observed prevalence was significantly associated with the gestational period, whereas no relationship was found for other risk factors.

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“…Primary studies conducted in the East African countries showed the colonization rates ranged from 3.0% to 28.8% [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]; Central Africa,20.0% [27,28]; Western Africa, 2.5% to 34.2% [29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48]; Southern Africa, 1.77% to 48.23% [49][50][51][52][53][54][55][56][57]…”

Section: Introductionmentioning

confidence: 99%

Streptococcus agalactiae maternal colonization, antibiotic resistance and serotype profiles in Africa: a meta-analysis

Gizachew

Tiruneh

Moges

et al. 2019

Ann Clin Microbiol Antimicrob

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Background: Maternal rectovaginal colonization with Streptococcus agalactiae (Group B Streptococcus or GBS) is the most common route for the GBS disease in the perinatal period. The knowledge of maternal colonization, antibiotic resistance and serotype profiles is substantially needed to formulate the broad vaccine. However, it has not been estimated in Africa. This meta-analysis was aimed to determine the pooled prevalence of colonization, antibiotic resistance and serotype profiles of GBS reported in Africa. Methods: Potentially relevant studies from 1989 to 31th January, 2019 were retrieved from the Medline/PubMed, EMBASE, HINARI online databases, periodicals and by requesting authors. Unpublished studies retrieved from grey literature through Google and Google Scholar. Pooled estimates were calculated using the random effect model. Subgroup analysis was done to investigate the burden of colonization across sub-regions, sampling site and countries. Summary estimates were presented using words, Forest plots and Tables. Heterogeneity was assessed using the I 2 statistic. Results: Eighty-three articles were assessed, of which 57 studies conducted in five sub-regions with 21 countries (22,206 pregnant women) met pre-specified inclusion criteria. The overall estimate of recto-vaginal colonization was 19.3% (95% CI 16.9, 21.7). The highest estimate was observed in Southern Africa, 23.8% (95% CI 18.7, 28.9), followed by Northern Africa, 22.7% (95% CI 18.2, 27.2) while the lowest was driven from the Eastern Africa, 15.4% (95% CI 12.1, 18.7). Considerable heterogeneity across and within regions, sampling site, screening methods and countries (I 2 > 75%); and the publication bias were observed (p = 0.031). GBS showed the highest resistance to tetracycline. Resistance to penicillin, amoxicillin, chloramphenicol, ampicillin, ceftriaxone, ciprofloxacin, erythromycin, vancomycin and clindamycin also observed. The V, III, Ia, Ib, and II serotypes altogether were accounted 91.8% in the African studies. Conclusions: The pooled estimate of the maternal colonization with GBS was 19.3% which is equivalent with other many primary and review reports worldwide. The most antibiotic resistance estimate was recorded in the tetracycline followed by penicillin. Five serotypes were the most prevalent in Africa and more data on the antibiotic résistance and serotype distribution patterns are needed from developing countries to devise the effective preventive measures. In addition, the antibiotic susceptibility test methods used in the Africa shall be assessed for its quality.

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Group B streptococcus colonisation in pregnant women at Dr. George Mukhari Hospital, South Africa

Cited by 9 publications

References 27 publications

Group B Streptococcus Serotypes in Pregnant Women From the Western Cape Region of South Africa

Group B Streptococcus Serotypes in Pregnant Women From the Western Cape Region of South Africa

Molecular Characterization of Streptococcus agalactiae Isolates from Pregnant Women in Kathmandu City

Streptococcus agalactiae maternal colonization, antibiotic resistance and serotype profiles in Africa: a meta-analysis

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