Group B Streptococcus and pregnancy: a review

Larsen, John W.; Sever, John L.

doi:10.1016/j.ajog.2007.11.030

Cited by 83 publications

(60 citation statements)

References 64 publications

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“…Streptococcus agalactiae (group B streptococcus) is a leading cause of morbidity and mortality in neonates and pregnant women worldwide (14). It is also recognized as an emerging significant pathogen in nonpregnant adults, including elderly persons and patients with underlying conditions such as diabetes mellitus or immunosuppression (22).…”

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confidence: 99%

Cross-Resistance to Lincosamides, Streptogramins A, and Pleuromutilins Due to the lsa (C) Gene in Streptococcus agalactiae UCN70

Malbruny

Werno

Murdoch

et al. 2011

Antimicrob Agents Chemother

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Streptococcus agalactiae UCN70, isolated from a vaginal swab obtained in New Zealand, is resistant to lincosamides and streptogramins A (LS A phenotype) and also to tiamulin (a pleuromutilin). By whole-genome sequencing, we identified a 5,224-bp chromosomal extra-element that comprised a 1,479-bp open reading frame coding for an ABC protein (492 amino acids) 45% identical to Lsa(A), a protein related to intrinsic LS A resistance in Enterococcus faecalis. Expression of this novel gene, named lsa(C), in S. agalactiae BM132 after cloning led to an increase in MICs of lincomycin (0.06 to 4 g/ml), clindamycin (0.03 to 2 g/ml), dalfopristin (2 to >32 g/ml), and tiamulin (0.12 to 32 g/ml), whereas no change in MICs of erythromycin (0.06 g/ml), azithromycin (0.03 g/ml), spiramycin (0.25 g/ml), telithromycin (0.03 g/ml), and quinupristin (8 g/ml) was observed. The phenotype was renamed the LS A P phenotype on the basis of cross-resistance to lincosamides, streptogramins A, and pleuromutilins. This gene was also identified in similar genetic environments in 17 other S. agalactiae clinical isolates from New Zealand exhibiting the same LS A P phenotype, whereas it was absent in susceptible S. agalactiae strains. Interestingly, this extra-element was bracketed by a 7-bp duplication of a target site (ATTAGAA), suggesting that this structure was likely a mobile genetic element. In conclusion, we identified a novel gene, lsa(C), responsible for the acquired LS A P resistance phenotype in S. agalactiae. Dissection of the biochemical basis of resistance, as well as demonstration of in vitro mobilization of lsa(C), remains to be performed.

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confidence: 99%

Cross-Resistance to Lincosamides, Streptogramins A, and Pleuromutilins Due to the lsa (C) Gene in Streptococcus agalactiae UCN70

Malbruny

Werno

Murdoch

et al. 2011

Antimicrob Agents Chemother

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“…Lower rates are attributed to false negative culture due to inadequate swabbing technique or poor handling, specimen storage conditions, and prolonged transport. Different positive culture rates are also attributed to use of different culture media [21,22].…”

Section: Discussionmentioning

confidence: 99%

Risk Factors Associated with Group B Streptococcus Colonization and Their Effect on Pregnancy Outcome

Lekala

Mavenyengwa

Moyo

et al. 2015

JGO

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“…Na década seguinte, demonstrou-se que os índices de infecção neonatal pelo agente foram bastante reduzidos, depois de instituída a antibioticoterapia durante o parto para as mulheres de risco (LARSEN;SEVER, 2008). Diante disso, medidas profiláticas têm sido incentivadas em nível internacional, com o intuito de diminuir a incidência das infecções e suas possíveis consequências ao neonato (POGERE et al, 2005).…”

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Pesquisa de Streptococcus Agalactiae na Secreção Vaginal e Anal de Gestantes de um Município do Noroeste Paulista

Rezende

Azeredo

Silveira

et al. 2010

RBM

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RESUMOO Streptococcus agalactiae tem grande importância médica nas infecções neonatais graves associadas com morbidade e mortalidade. É a bactéria mais frequentemente isolada dos quadros de septicemia, pneumonia e meningite neonatal. Este estudo teve como objetivo determinar a prevalência de colonização anal e vaginal de Streptococcus agalactiae em gestantes em diferentes idades gestacionais. A incidência de colonização por S. agalactiae foi avaliada em 129 gestantes de qualquer idade gestacional. Foram coletadas duas amostras de secreção para cultura: um swab perianal e um swab vaginal. Cada um dos dois swabs foi inoculado em tubo de ensaio contendo caldo de Todd-Hewitt e subcultivados em ágar sangue. Após 24 a 48 horas, as colônias sugestivas de Streptococcus agalactiae foram submetidas à análise morfotintorial e a provas bioquímicas para identificação. Das 129 gestantes analisadas, 3 (2,33%) tiverem cultura positiva para Streptococcus agalactiae e 126 (97,67%) apresentaram resultado negativo. Os resultados apresentados neste trabalho estão abaixo dos dados de outros estudos, entretanto, a metodologia utilizada foi compatível com a maioria dos autores. Ainda assim, essa taxa é considerada um valor relevante, tendo em vista a importância do Streptococcus agalactiae em infecções em gestantes e neonatos, ressaltando a necessidade de estimular a cultura de secreção vaginal e anal para pesquisa de Streptococcus agalactiae nos exames de pré-natal. PALAVRAS-CHAVE:Streptococcus agalactiae; Gestante; Colonização. ABSTRACTStreptococcus agalactiae has great medical importance in infections associated with severe neonatal morbidity and mortality. It is the most frequent bacterium isolated from the tables of septicemia, pneumonia and neonatal meningitis. This study aimed to determine the prevalence of anal and vaginal colonization of S. agalactiae in pregnant women at different gestational ages. We evaluated the incidence of colonization by S. agalactiae in 129 pregnant women of any age. Two samples of secretion were collected for culture: a perianal swab and a vaginal swab. Each of the two swabs were inoculated in test tubes containing Todd-Hewitt broth and subcultured on blood agar. After a period of 24 to 48 hours, the colonies suggestive of S. agalactiae were submitted to morfotintorial analysis and to biochemical tests for identification. Among 129 women studied, 3 (2.33%) have tested positive for Streptococcus agalactiae and 126 (97.67%) were negative. The results presented in this

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Group B Streptococcus and pregnancy: a review

Cited by 83 publications

References 64 publications

Cross-Resistance to Lincosamides, Streptogramins A, and Pleuromutilins Due to the lsa (C) Gene in Streptococcus agalactiae UCN70

Cross-Resistance to Lincosamides, Streptogramins A, and Pleuromutilins Due to the lsa (C) Gene in Streptococcus agalactiae UCN70

Risk Factors Associated with Group B Streptococcus Colonization and Their Effect on Pregnancy Outcome

Pesquisa de Streptococcus Agalactiae na Secreção Vaginal e Anal de Gestantes de um Município do Noroeste Paulista

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