Group B streptococcal disease in UK and Irish infants younger than 90 days

Heath, Paul T; Balfour, Gail; Weisner, Abbie M.; Efstratiou, Androulla; Lamagni, Theresa; Tighe, Helen; o’connell, liam; Cafferkey, Mary T.; Verlander, Neville Q.; Nicoll, A; McCartney, A. Christine

doi:10.1016/s0140-6736(03)15389-5

Cited by 231 publications

(262 citation statements)

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“…Therefore, neonatal listeriosis remains to be a rare disease. However, the casefatality rate of neonatal listeriosis remains high; in our case series this was 21% (24% if probable cases were included) whereas the more common Group B streptococcal infection has a lower fatality rate (9.7%) [17]. Therefore, despite its rarity, improvements in the recognition and prevention of listeriosis need to be identified.…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 71%

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Neonatal listeriosis in the UK 2004–2014

Sapuan

Kortsalioudaki

Anthony

et al. 2017

Journal of Infection

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ObjectiveTo define the clinical features and outcomes of neonatal listeriosis, and identify the maternal risk factors to seek scope for improvement. MethodsNeonatal listeriosis was identified prospectively from a United Kingdom neonatal infection surveillance network (neonIN) between 2004 and 2014. The participating neonatal units completed a study-specific proforma. ResultsThe incidence of neonatal listeriosis was 3.4 per 100,000 live births. Of the 21 cases identified, 19 were confirmed with a median gestational age of 33 weeks and a median birth weight of 1960g. The majority had clinical features (95%, 18/19), presented within the first 24 hours (95%, 18/19), and received penicillin empirically (94%, 18/19). The neonatal casefatality rate was 21% (24% if probable cases were included). A proportion of mothers were investigated (60%, 12/18) and diagnosed with listeriosis (58%, 7/12); 32% (6/19) were treated with antibiotics but only 33% (6/12) included penicillin. DiscussionDespite its rarity and the prompt and appropriate use of antibiotics neonatal listeriosis has a high case-fatality rate. There is room for improvement in the adherence to the national guidance in the choice of empiric antibiotics for puerperal sepsis, which would target listeriosis. Strategies should be in place to prevent pregnancy-associated listeriosis in higher risk population.

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Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 71%

“…of neonatal infection, such as Group B streptococcal infection, with an incidence of 72 per 100,000 live births [17]. Therefore, neonatal listeriosis remains to be a rare disease.…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Neonatal listeriosis in the UK 2004–2014

Sapuan

Kortsalioudaki

Anthony

et al. 2017

Journal of Infection

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“…This intervention has high effi cacy in preventing early-onset group B streptococcus and has substantially reduced the incidence of early-onset disease since its introduction in the 1990s. 8,9,37 Risk of group B streptococcal disease was two-times less in studies with small proportions (<20%) of infected low-birthweight infants than in studies with proportions ranging from 20-39%. Infants with low birthweight have a high risk of group B streptococcal infection and underrepresentation in a study sample can lead to substantial underestimations.…”

Section: Discussionmentioning

confidence: 98%

“…We also gathered data on potential explanatory variables (ie, variables that might explain variance in incidence or risk of group B streptococcus; 21 Andersen et al 22 Ekelund et al 23 Kuhn et al 24 Fluegge et al 25 Berardi et al 26 Trijbels-Smeulders et al 27 van den Hoogen et al 28 Hasseltvedt et al 29 Hajdu et al 30 Neto et al 31 Janek et al 32 Carbonell-Estrany et al 33 Lopez Sastre et al 34 Andreu et al 35 Persson et al 36 Heath et al 37 Oddie et al 38 Weisner et al 39 Vergnano et al 40 Subtotal (I 2 =98·6%, p=0·000)…”

Section: Data Extractionmentioning

confidence: 99%

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Group B streptococcal disease in infants aged younger than 3 months: systematic review and meta-analysis

Edmond¹,

Kortsalioudaki²,

Scott³

et al. 2012

The Lancet

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524

457

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SummaryBackground Despite widespread use of intrapartum antibiotic prophylaxis, group B streptococcus remains a leading cause of morbidity and mortality in infants in Europe, the Americas, and Australia. However, estimates of disease burden in many countries outside of these regions is not available. We aimed to examine the current global burden of invasive disease and the serotype distribution of group B streptococcus isolates.

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