Neonatal listeriosis in the UK 2004–2014

Sapuan, Shari; Kortsalioudaki, Christina; Anthony, Mark; Chang, John; Embleton, Nicholas D.; Geethanath, R; Gray, Jim; Greenough, Anne; Lal, Mithilesh; Luck, Suzanne; Pattnayak, Santosh; Reynolds, Peter; Russell, Allison B.; Scorrer, Tim; Turner, Mark A.; Heath, Paul T; Vergnano, Stefania

doi:10.1016/j.jinf.2016.11.007

Cited by 35 publications

(37 citation statements)

References 12 publications

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“…However, we also observed a high CFR (46.7%) in newborns, although outcome was known only for 38.5% cases and this was not statistically significant (p = 0.79). High fatality rates of listeriosis in newborns were also reported in Lombardy, Italy (30%), and in England (24%) 21 , 22 . Recently, a French study suggested that CFR might be generally higher in pregnancy-related cases than reported to date.…”

Section: Discussionmentioning

confidence: 78%

Molecular diversity and antimicrobial susceptibility of Listeria monocytogenes isolates from invasive infections in Poland (1997–2013)

Kuch

Goc

Belkiewicz³

et al. 2018

Sci Rep

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The epidemiology of invasive listeriosis in humans appears to be weakly characterized in Poland, the sixth most populous member state of the European Union. We obtained antimicrobial susceptibility data, PCR-serogroups and genotypic profiles for 344 invasive isolates of Listeria monocytogenes, collected between 1997 and 2013 in Poland. All isolates were susceptible to the 10 tested antimicrobials, except one that was resistant to tetracycline and minocycline and harbored the tet(M), tet(A) and tet(C) genes. Overall, no increasing MIC values were observed during the study period. Four PCR-serogroups were observed: IVb (55.8%), IIa (34.3%), IIb (8.1%) and IIc (1.8%). We identified clonal complexes (CCs) and epidemic clones (ECs) previously involved in outbreaks worldwide, with the most prevalent CCs/ECs being: CC6/ECII (32.6%), CC1/ECI (17.2%), CC8/ECV (6.1%) and CC2/ECIV (5.5%). The present study is the first extensive analysis of Polish L. monocytogenes isolates from invasive infections.

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Section: Discussionmentioning

confidence: 78%

Molecular diversity and antimicrobial susceptibility of Listeria monocytogenes isolates from invasive infections in Poland (1997–2013)

Kuch

Goc

Belkiewicz³

et al. 2018

Sci Rep

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“…Usually, pregnant women, the newborn, elderly people, and immunocompromised individuals are more susceptible to listeriosis, but it may occasionally occur in healthy individuals. The prevalence of listeriosis among pregnant women, neonates, and the elderly is 12, 3.4, and 10 per 100,000, respectively, compared with 0.7 per 100,000 in the general population (Goulet, Hedberg, Le Monnier, & De Valk, ; Sapuan et al., ; Southwick & Purich, ). Listeriosis has an average fatality rate of 20% to 30% even with the application of antibiotic therapy (Swaminathan & Gerner‐Smidt, ).…”

Section: Human Listeriosismentioning

confidence: 99%

Emergence of Antibiotic Resistance in Listeria monocytogenes Isolated from Food Products: A Comprehensive Review

Olaimat

Al‐Holy

Shahbaz

et al. 2018

Comp Rev Food Sci Food Safe

176

120

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Listeria monocytogenes is an opportunistic pathogen that has been involved in several deadly illness outbreaks. Future outbreaks may be more difficult to manage because of the emergence of antibiotic resistance among L. monocytogenes strains isolated from food products. The present review summarizes the available evidence on the emergence of antibiotic resistance among L. monocytogenes strains isolated from food products and the possible ways this resistance has developed. Furthermore, the resistance of food L. monocytogenes isolates to antibiotics currently used in the treatment of human listeriosis such as penicillin, ampicillin, tetracycline, and gentamicin, has been documented. Acquisition of movable genetic elements is considered the major mechanism of antibiotic resistance development in L. monocytogenes. Efflux pumps have also been linked with resistance of L. monocytogenes to some antibiotics including fluoroquinolones. Some L. monocytogenes strains isolated from food products are intrinsically resistant to several antibiotics. However, factors in food processing chains and environments (from farm to table) including extensive or sub-inhibitory antibiotics use, horizontal gene transfer, exposure to environmental stresses, biofilm formation, and presence of persister cells play crucial roles in the development of antibiotic resistance by L. monocytogenes.

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“…About half the infants who are infected with L. monocytogenes have no apparent immunocompromising condition [16]. Neonatal listeriosis is associated with an overall case fatality rate of 50% [17], with severe neurological and developmental sequalae observed in 40% of surviving neonates [18]. Due to the severity of the illness, in New Zealand (NZ) all neonates with suspected infection are treated with amoxicillin which targets L. monocytogenes, as well as other infections [19].…”

Section: Introductionmentioning

confidence: 99%

The epidemiology of listeriosis in pregnant women and children in New Zealand from 1997 to 2016: an observational study

et al. 2020

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Background: Listeria monocytogenes causes the foodborne infection listeriosis. Pregnant women, infants and immunocompromised children are at increased risk for infection. The aim of this study was to describe the trends in the epidemiology of disease notifications and hospital admissions due to listeriosis in pregnant women aged 15 to 45 years and children aged less than 15 years in New Zealand (NZ) from 1997 to 2016. Methods: In this population-based descriptive study, listeriosis notification and hospitalization rates from 1997 to 2016 were analyzed. Notification data were extracted from the Institute of Environmental Science and Research (ESR) Notifiable Diseases Database (EpiSurv) and hospitalization data were extracted from the National Minimum Dataset (NMDS). Pregnant women aged 15 to 45 years and children less than 15 years of age were included. Subgroup analysis was conducted for age and ethnicity. Outcomes of infection were described. Results: In the 20-year period considered, there were 147 pregnancy-associated cases of listeriosis either notified to ESR (n = 106) and/or coded in the NMDS (n = 99), giving a crude incidence rate of 12.3 (95% CI 10.4, 14.4) per 100, 000 births. In addition, there were 22 cases in children aged 28 days to < 15 years (incidence =0.12, 95% CI 0.08 to 0.19 per 100,000). There were no trends observed over time in the incidence of pregnancy-associated listeriosis. Incidence rates of pregnancy-associated and childhood listeriosis were highest in people of Pacific and Asian ethnicity. Conclusions: NZ has a low incidence of listeriosis in pregnant women and children, however, the consequences of infection are frequently severe. Those of Pacific and Asian ethnicity have the highest rates of disease and future messaging around food safety should target these groups. This study provides important insights into the epidemiology of listeriosis in pregnant women and children in NZ.

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Neonatal listeriosis in the UK 2004–2014

Cited by 35 publications

References 12 publications

Molecular diversity and antimicrobial susceptibility of Listeria monocytogenes isolates from invasive infections in Poland (1997–2013)

Molecular diversity and antimicrobial susceptibility of Listeria monocytogenes isolates from invasive infections in Poland (1997–2013)

Emergence of Antibiotic Resistance in Listeria monocytogenes Isolated from Food Products: A Comprehensive Review

The epidemiology of listeriosis in pregnant women and children in New Zealand from 1997 to 2016: an observational study

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