Group A Streptococcus Meningitis in Children

Torres, Rosângela Stadnick Lauth de Almeida; Fedalto, Luiz Ernesto; Torres, Rômulo Francisco de Almeida; Steer, Andrew C.; Smeesters, Pierre

doi:10.1097/inf.0b013e31826fd4af

Cited by 29 publications

(21 citation statements)

References 60 publications

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“…A literature review since 1966 reveals 17 documented cases of neonatal meningitis with CSF cultures positive for group a streptococcus [1,2,4,[6][7][8][9][10][11][12][13][14][15] (Table 1). The previously published reports originated in the following countries: Brazil (N = 4), USA (N = 3), the UK (N = 3), Morocco (N = 2), India (N = 1), Israel (N = 1), Saudi Arabia (N = 1), The Netherlands (N = 1) and Turkey (N = 1).…”

Section: Review Of the Literaturementioning

confidence: 99%

“…In the early half of the twentieth century, Streptococcus pyogenes (group a streptococcus (GAS)) was considered a prevalent and important cause of neonatal sepsis and meningitis. However, since the advent and widespread use of antibiotics, it has become a rarely reported cause of neonatal sepsis [1][2][3], often accompanied by a rather severe and occasionally fatal disease course [1,2,[4][5][6]. Here, we review the clinical characteristics of previously reported cases of and present a case of GAS meningitis in a 10-day old, well appearing neonate, most likely resulting from maternal transmission.…”

Section: Introductionmentioning

confidence: 95%

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Neonatal Group A Streptococcus Meningitis. Case Report and Literature Review

Talmy¹,

Mazor

Nasser

et al. 2020

SN Compr. Clin. Med.

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Group A streptococci (GAS) have previously accounted for a large portion of invasive neonatal infections, but differences in the access to medical care and in the antibiotic used over the last half century has significantly reduced such cases. A literature review reveals 17 neonatal GAS meningitis reports with positive CSF cultures since 1967, characterized by high morbidity and mortality. We present a case of a 10-day old well-appearing neonate diagnosed with GAS meningitis, exhibiting an excellent response to antimicrobial therapy. Epidemiological investigation revealed her mother as the likely source of postnatal transmission of GAS with an emm1.0 subtype. GAS meningitis is a rare cause of neonatal meningitis associated with high morbidity and mortality warranting further research assessing potential risk factors, modes of transmission, and therapeutic protocols.

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Section: Review Of the Literaturementioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

Neonatal Group A Streptococcus Meningitis. Case Report and Literature Review

Talmy¹,

Mazor

Nasser

et al. 2020

SN Compr. Clin. Med.

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“…Previous reports have demonstrated that GAS meningitis accounts for <2% of cases of pyogenic meningitis in the United States (5) and Netherlands (6), and surprisingly no cases in Canada (7). However, the case fatality rate is reported to be high: 43% in children (8) and 27% in adults (6). Even among survivors, neurological sequelae are observed in 43% of adult patients (6).…”

Section: Introductionmentioning

confidence: 96%

Group A Streptococcal Meningitis in a Patient with Palmoplantar Pustulosis

Hagiya

Otsuka

2013

Intern. Med.

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A 64-year-old man with a 10-year history of palmoplantar pustulosis, a recent history of cranial surgery and a persistent upper airway infection presented with a high fever and deep coma. The patient was diagnosed with Group A Streptococcal meningitis and promptly treated with antibiotics. Although his general condition recovered well, sensorineural hearing loss and facial palsy remained. Group A Streptococcal meningitis is a rare condition, and its typical clinical picture and epidemiological features remain poorly understood. Physicians need to be more aware of this infection, which is extremely rare but frequently causes various complications and yields a high mortality.

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“…La enfermedad invasiva del estreptococo del grupo A (GAS) es una causa aumento de morbilidad y mortalidad, y su incidencia ha ido en aumento en países industrializados. La meningitis por este germen es una enfermedad especialmente rara (9)(10)(11) .…”

Section: Introductionunclassified

Meningitis in the National Hospital: VI national epidemiological sample

Leguizamón

Guillén

Gómez

et al. 2017

Rev. Nac. (Itauguá)

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RESUMENIntroducción: las meningitis constituyen un importante problema de Salud Pública, que afectan de manera especial a los niños menores de 5 años. La etiología más frecuente es viral. Desde la introducción de la vacuna conjugada contra H. influenzae tipo b, S. pneumoniae y N. meningitidis los virus pasaron a ser los agentes más frecuentes. A nivel país, en 2014 y 2015, la etiología viral fue la más frecuente con valores de 69% y 77%, respectivamente, atribuyéndose a las bacterianas como segunda causa. Rev. Nac. (Itauguá).2017; 9(1):61-77

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Group A Streptococcus Meningitis in Children

Abstract: GAS meningitis is associated with high mortality and with a high diversity of GAS emm-types and virulence determinants in Brazil.

Cited by 29 publications

References 60 publications

Neonatal Group A Streptococcus Meningitis. Case Report and Literature Review

Neonatal Group A Streptococcus Meningitis. Case Report and Literature Review

Group A Streptococcal Meningitis in a Patient with Palmoplantar Pustulosis

Meningitis in the National Hospital: VI national epidemiological sample

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