Group A streptococcal polysaccharide inhibits the functional activity of CD8+ supressor cells stimulated with ConA in a human blood mononuclear cell culture

Gnezditskaya, É. V.; Bazanova, E. A.; Нестеренко, В. Г.; Popova, Lana; Sanina, V. Yu.

doi:10.1007/bf00850917

Cited by 2 publications

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“…Previously a correlation between inhibition of suppressor activity and lowering of the activation index in a subpopolation of lymphocytes with the CD8 § phenotype was revealed for the CortA system [4]. These data indicate that A-PS can inhibit the process of differentiation of CD8 § suppressors proliferating under the effect of mitogen.…”

Section: Resultsmentioning

confidence: 80%

“…suppressors and destruction of MTT (3-[4,5dimethylthiasole-2-yl]-2, 5-diphenyltetrazolium bromide, Sigma) in the cytoplasm of lymphocytes labeled with it [4]. The MTT label used with monoclonal antibodies to markers of different Tcell subpopulations helps investigate the effects of different immunomodulators on the functional activity of individual lymphocyte subpopulations by the immunofluorescent method [4,9,10].…”

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Role of the specific determinant of group A streptococcus polysaccharide in inhibition of T-suppressor activity

et al. 1995

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Group A streptococcus polysaccharide is found to inhibit the activity of ConA-stimulated T suppressors. A-variant streptococcus polysaccharide, representing an L-rhamnose homopolymer which is identical to the rhamnose carcass of group A streptococcus polysaccharide, does not possess such an effect. The effect of group A streptococcus polysaccharide on the activity of T suppressors is considered to be associated with its determinant including N-acetylglucosamine as an obligatory component.

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Section: Resultsmentioning

confidence: 80%

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confidence: 99%

Role of the specific determinant of group A streptococcus polysaccharide in inhibition of T-suppressor activity

et al. 1995

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Preparation and characterization of monoclonal antibodies to group-specific antigenic determinant of group a streptococcus polysaccharide

et al. 1999

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Group A streptococcus polysaccharide contains at least two different group-specific determinants including N-acetyl-~-D-glucosamine (more important) and rhamnose. Monoclonal antibodies to group-specific determinants of group A streptococcus polysaccharide do not react with tissue antigens. Cross reactions with tissues were detected in tests with monoclonal antibodies to rhamnose-enriched epitopes of group A streptococcus polysaccharide.

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Group A streptococcal polysaccharide inhibits the functional activity of CD8+ supressor cells stimulated with ConA in a human blood mononuclear cell culture

Cited by 2 publications

References 3 publications

Role of the specific determinant of group A streptococcus polysaccharide in inhibition of T-suppressor activity

Role of the specific determinant of group A streptococcus polysaccharide in inhibition of T-suppressor activity

Preparation and characterization of monoclonal antibodies to group-specific antigenic determinant of group a streptococcus polysaccharide

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