Preparation and characterization of monoclonal antibodies to group-specific antigenic determinant of group a streptococcus polysaccharide

Abstract

Group A streptococcus polysaccharide contains at least two different group-specific determinants including N-acetyl-~-D-glucosamine (more important) and rhamnose. Monoclonal antibodies to group-specific determinants of group A streptococcus polysaccharide do not react with tissue antigens. Cross reactions with tissues were detected in tests with monoclonal antibodies to rhamnose-enriched epitopes of group A streptococcus polysaccharide.