Group A rotavirus in Brazilian bats: description of novel T15 and H15 genotypes

Asano, Karen Miyuki; Gregori, Fábio; Hora, Aline Santana da; Scheffer, K. C.; Fahl, W. O.; Iamamoto, Keila; Mori, Ênio; Silva, Fernanda Dornelas Florentino; Taniwaki, Sueli Akemi; Brandão, Paulo Eduardo

doi:10.1007/s00705-016-3010-9

Cited by 20 publications

(23 citation statements)

References 37 publications

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“…1). BLAST searches indicated that the VP7 gene segment of the study strain was also closely related to the Ecuadorian human RVA strain Ecu534 and bat RVA strain 3081/BRA detected in Brazil in 2013 (Asano et al, 2016) and showed nucleotide (amino acid) identities of 81.8% (96.4%) and 81.3% (95.3%), respectively (Fig. 1).…”

Section: Resultsmentioning

confidence: 87%

“…Several improvements in viral detection and characterization methodologies such as high-throughput next generation sequencing have led to a successful discovery and characterization of several novel viruses in bats, including enteric pathogens such as RVA (Luis et al, 2013; Waruhiu et al, 2017). However, since the first detection and characterization of a human-bat reassortant RVA from a Straw-colored Fruit bat in 2010 (Esona et al, 2010), a few of other bat RVA strains, detected and characterized from different bat species and different geographic locations have been reported (Asano et al, 2016; He et al, 2013; Sasaki et al, 2016; Waruhiu et al, 2017; Xia et al, 2013; Yinda et al, 2016). Among the reported bat RVA strains, only bat RVA strain 3081/BRA from Brazil was closely related in the VP7, NSP3 and NSP5 gene segments with the study strain from Suriname.…”

Section: Resultsmentioning

confidence: 99%

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Molecular characterization of a human G20P[28] rotavirus a strain with multiple genes related to bat rotaviruses

Esona

Roy

Rungsrisuriyachai

et al. 2018

Infection, Genetics and Evolution

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Group A rotaviruses are the major cause of severe gastroenteritis in the young of mammals and birds. This report describes characterization of an unusual G20P[28] rotavirus strain detected in a 24 month old child from Suriname. Genomic sequence analyses revealed that the genotype constellation of the Suriname strain RVA/Human-wt/SUR/2014735512/2013/G20P[28] was G20-P[28]-I13-R13-C13-M12-A23-N13-T15-E20-H15. Genes VP1, VP2, VP3, NSP1, NSP2, NSP3, NSP4 and NSP5 were recently assigned novel genotypes by the Rotavirus Classification Working Group (RCWG). Three of the 11 gene segments (VP7, VP4, VP6) were similar to cognate gene sequences of bat-like human rotavirus strain Ecu534 from Ecuador and the VP7, NSP3 and NSP5 gene segments of strain RVA/Human-wt/SUR/2014735512/2013/G20P[28] were found to be closely related to gene sequences of bat rotavirus strain 3081/BRA detected in Brazil. Although distantly related, the VP1 gene of the study strain and bat strain BatLi09 detected in Cameroon in 2014 are monophyletic. The NSP1 gene was found to be most closely related to human strain QUI-35-F5 from Brazil. These findings suggest that strain RVA/Human-wt/SUR/2014735512/2013/G20P[28] represents a zoonotic infection from a bat host.

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Section: Resultsmentioning

confidence: 87%

Section: Resultsmentioning

confidence: 99%

Molecular characterization of a human G20P[28] rotavirus a strain with multiple genes related to bat rotaviruses

Esona

Roy

Rungsrisuriyachai

et al. 2018

Infection, Genetics and Evolution

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“…Recent years have witnessed considerable sequence data accumulation in public data bases pointing out the enormous genetic diversity within the Rotavirus genus. Viral metagenomics largely contributed to our understanding of this genetic diversity (Asano et al, 2016;He et al, 2013;Kluge et al, 2016;Li et al, 2011;Marton et al, 2015;Mihalov-Kovács et al, 2015;Theuns et al, 2016;Xia et al, 2014). Until the early 2000s RVA to RVG were considered as the only extant RV species (Estes and Greenberg, 2013;Matthijnssens et al, 2012).…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, bats seem to serve as reservoirs of multiple RVA genotypes commonly found in heterologous host species. Consequently, batborne RVAs might pose some veterinary and public health risk (Asano et al, 2016;He et al, 2013;Xia et al, 2014). More recent data indicate that in addition to RVA, RVH may also infect bats (Kim et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Candidate new rotavirus species in Schreiber's bats, Serbia

Bányai

Kemenesi

Budinski

et al. 2017

Infection, Genetics and Evolution

171

146

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The genus Rotavirus comprises eight species designated A to H and one tentative species, Rotavirus I. In a virus metagenomic analysis of Schreiber's bats sampled in Serbia in 2014 we obtained sequences likely representing novel rotavirus species. Whole genome sequencing and phylogenetic analysis classified the representative strain into a tentative tenth rotavirus species, we provisionally called Rotavirus J. The novel virus shared a maximum of 50% amino acid sequence identity within the VP6 gene to currently known members of the genus. This study extends our understanding of the genetic diversity of rotaviruses in bats.

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“…For example, bats are hosts of rotaviruses, and some strains of rotavirus are genetically related to other mammalian rotaviruses, although other strains are bat-specific 7,181 . The significance of bats as a reservoir for rotavirus transmission to other mammalian species (including humans) remains to be determined.…”

Section: Discussionmentioning

confidence: 99%

Rotavirus infection

Crawford

Ramani

Tate

et al. 2017

Nat Rev Dis Primers

526

558

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Rotavirus infections are a leading cause of severe, dehydrating gastroenteritis in children <5 years of age. Despite the global introduction of vaccinations for rotavirus over a decade ago, rotavirus infections still result in >200,000 deaths annually, mostly in low-income countries. Rotavirus primarily infects enterocytes and induces diarrhoea through the destruction of absorptive enterocytes (leading to malabsorption), intestinal secretion stimulated by rotavirus non-structural protein 4 and activation of the enteric nervous system. In addition, rotavirus infections can lead to antigenaemia (which is associated with more severe manifestations of acute gastroenteritis) and viraemia, and rotavirus can replicate in systemic sites, although this is limited. Reinfections with rotavirus are common throughout life, although the disease severity is reduced with repeat infections. The immune correlates of protection against rotavirus reinfection and recovery from infection are poorly understood, although rotavirus-specific immunoglobulin A has a role in both aspects. The management of rotavirus infection focuses on the prevention and treatment of dehydration, although the use of antiviral and anti-emetic drugs can be indicated in some cases.

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Group A rotavirus in Brazilian bats: description of novel T15 and H15 genotypes

Cited by 20 publications

References 37 publications

Molecular characterization of a human G20P[28] rotavirus a strain with multiple genes related to bat rotaviruses

Molecular characterization of a human G20P[28] rotavirus a strain with multiple genes related to bat rotaviruses

Candidate new rotavirus species in Schreiber's bats, Serbia

Rotavirus infection

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