Group 1 and 2<i>Dermatophagoides</i>house dust mite allergens in the microenvironment of cats

Loft, K. E.; Rosser, Edmund J.

doi:10.1111/j.1365-3164.2009.00771.x

Cited by 14 publications

(13 citation statements)

References 40 publications

(148 reference statements)

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“…From 50 cat-only households with 95 cats, dust samples, by use of by vacuuming from areas where cats slept/rested, were analyzed via ELISA for Der p 1, Der f 1 and HDM group 2 allergens. Out of 50 households 38 were greater than 2 micro gr (-1) of dust for at least one HDMA (19).…”

Section: Discussionmentioning

confidence: 99%

“…Latter data should lead to further determination of the role of HDMs in cats suffering from putative allergic conditions such as atopic dermatitis or asthma (19). In the present study a statistical significance for specific IgE levels between healthy controls and allergic cats against house dust mites 0.21±0.018 vs 4.69±1.49 (kU/l) for D. farinae (p=0.0001) and significant alterations between healthy controls and allergic cats 0.21±0.023 vs 3.11±1.21 (kU/l) (p=0.003) for DP.…”

Section: Discussionmentioning

confidence: 99%

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House dust mite specific in vitro IgE determination in cats with allergic dermatitis

Ural

Paşa

Erdoğan

et al. 2019

Veterinary Journal of Mehmet Akif Ersoy University

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The purpose of this retrospective research was to verify underlying causes of clinical findings in cats with allergic dermatitis. Allergen specific immunolglobulin E (IgE) concentrations against Dermatophagoides farinae and Dermatophagoides pteronyssinus were determined by use of in vitro Polycheck Veterinary allergy tests. Total of 33 cats were referred to clinic with primary/secondary skin lesions or to those of general health status checkup. On initial referral available haematological, microbiological, parasitological and relevant tests were performed. Nineteen cats were deemed healthy based on relevant analysis (neither infection nor hypersensitivity) were enrolled as a control group. Other 14 cats were composed of allergic cases. Regarding allergen specific IgE levels (kU/l) in allergic cats, in vitro tests gave a positive reactions for D. farinae [class 3,4 (n=1), class 2 (n=7), class 1 (n=6) and class 0 (n=0)] and D. pteronyssus [class 3,4 (n=1), class 2(n=5), class 1(n=4) and class 0 (n=4)] in whom at least 1 antigen was detected in all allergic cats. There was a statistical significance for specific IgE levels between healthy controls and allergic cats against house dust mites 0.21±0.018 vs. 4.69±1.49 (kU/l) for D. farinae (p=0.0001) and significant alterations between healthy and allergic cats 0.21±0.023 vs. 3.11±1.21 (kU/l) (p=0.003) for D. pteronyssus. In this study, all positive reactions on the allergy test were suggested to present underlying house dust allergens of dermatitis in enrolled cats. As far as wellknown factor that in vitro allergy tests solely might not be reflecting hypersensitivity from healthy cases because of non-unique clinically findings. Alerjik dermatitli kedilerde ev tozu akarlarına spesifik in vitro Ig E düzeylerinin araştırılması ÖZ Bu retrospektif araştırmanın amacı, alerjik dermatitli kedilerin klinik bulgularının altında yatan nedenleri tespit etmektir. Dermatophagoides farina ve Dermatophagoides pteronyssinus'a karşı alerjen spesifik Ig E konsantrasyonları, in vitro Polycheck Veteriner alerji testleri kullanılarak belirlendi. Primer / sekonder deri lezyonları olan veya genel sağlık durumu kontrolü için gelen toplamda 33 kedi çalışmaya alındı. Öncelikle mevcut hematolojik, mikrobiyolojik, parazitolojik ve ilgili analizler yapıldı. On dokuz kedi, ilgili analize dayalı olarak sağlıklı kabul edildi (ne enfeksiyon ne de aşırı duyarlılık gelişmiş) kontrol grubu olarak kaydedildi. Diğer 14 kedi alerjik vakalardan oluşuyordu. Alerjik kedilerde alerjene spesifik IgE seviyeleri (kU / l) ile ilgili olarak, in vitro testler, D. farinae için [sınıf 3,4 (n = 1), sınıf 2 (n = 7), sınıf 1 (n = 6), sınıf 0 (n= 0)] ve D. pteronyssinus için[sınıf 3,4 (n = 1), sınıf 2 (n = 5), sınıf 1 (n = 4) ve sınıf 0 (n = 4)] pozitif reaksiyonlar verdi. Bütün alerjik kedilerde en az 1 antijen saptandı. Sağlıklı kontrol grubu ve alerjik kediler arasında ev tozu akarlarına karşı spesifik Ig E seviyeleri için istatistiksel olarak anlamlı bir farklılık mevcuttu; D. farinae için 0.21 ± 0.018'e karşılık 4.69 ±...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

House dust mite specific in vitro IgE determination in cats with allergic dermatitis

Ural

Paşa

Erdoğan

et al. 2019

Veterinary Journal of Mehmet Akif Ersoy University

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“…). Treatment of pets with insecticides such as Fipronil is known to be an effective acaricide (Coleman & Atwell, ), while flea control agents have been associated with lower levels of Der p 1 in the microenvironments of dogs (Raffan et al , ) and cats (Loft & Rosser, ). However, questionnaire respondents indicated that none of the pets examined in this study had been treated with any kind of insecticide or acaricide, thus ruling out any acaricidal effect on mite densities and allergen levels in samples from HP.…”

Section: Discussionmentioning

confidence: 99%

The influence of household pets on the composition and quantity of allergenic mite fauna within Irish homes: a preliminary investigation

Clarke

Dix

Liddy

et al. 2015

Medical Vet Entomology

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Allergenic mites are responsible for inducing hypersensitive reactions in genetically predisposed people worldwide. Mites in dust from 30 Irish homes with pets (dogs, n = 23; cats, n = 7) were compared with those in 30 homes without pets. House dust mites constituted 78% of all mites recorded, with Dermatophagoides pteronyssinus (Acariformes: Pyroglyphidae) representing 57-72% of mites in furniture and mattresses in both home types compared with only 22% of mites in pet beds. Although storage mites accounted for just 13% of all mites recorded, they represented 46% of mites recorded in pet beds. Median levels of the dust mite allergen Der p 1 (µg/g) in dust samples from mattresses in homes without pets were significantly greater than in mattresses from homes with pets, reflecting the greater densities of D. pteronyssinus found in the former home category. Mite species richness was greater in homes with pets (17 species) than in homes without pets (13 species). This suggests that although the presence of pets can result in a wider variety of epidemiologically important mite species within households, increased competition among mite species may result in a more balanced mite fauna in the home, inhibiting the dominance of any one species and hence lowering allergen-associated risks.

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“…The AD in cats is not necessarily connected with the levels of IgE or the diagnosis of specific IgE antibodies in serum [ 49 ]. IgE to environmental allergens including pollen can be even found in pathogen-free housed cats [ 50 , 51 ]. When two groups of 10 cats each were intradermally tested, immediate reactivity was reported as IgE- as well as IgG-mediated reaction, but also explained by nonspecific mast cell degranulation [ 52 ].…”

Section: Reviewmentioning

confidence: 99%

“…Even in early studies specific IgG directed against ryegrass pollen, in addition to flea and house dust mite allergens, was reported and proposed as the second Th2 antibody class of relevance in feline allergy [ 53 ]. Rather than pollen, house dust mite allergens are found abundantly in the sleeping places of cats, but are not yet definitely proven to be causative allergens in feline AD or asthma [ 51 ].…”

Section: Reviewmentioning

confidence: 99%

Pollen Allergies in Humans and their Dogs, Cats and Horses: Differences and Similarities

Jensen‐Jarolim

Einhorn

Herrmann

et al. 2015

Clinical & Translational All

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Both humans and their most important domestic animals harbor IgE and a similar IgE receptor repertoire and expression pattern. The same cell types are also involved in the triggering or regulation of allergies, such as mast cells, eosinophils or T-regulatory cells. Translational clinical studies in domestic animals could therefore help cure animal allergies and at the same time gather knowledge relevant to human patients. Dogs, cats and horses may spontaneously and to different extents develop immediate type symptoms to pollen allergens. The skin, nasal and bronchial reactions, as well as chronic skin lesions due to pollen are in principle comparable to human patients. Pollen of various species most often causes allergic rhinitis in human patients, whereas in dogs it elicits predominantly eczematous lesions (canine atopic dermatitis), in horses recurrent airway obstruction or hives as well as pruritic dermatitis, and in cats bronchial asthma and so-called cutaneous reactive patterns (eosinophilic granuloma complex, head and neck pruritus, symmetric self-induced alopecia). In human allergy-specific IgE detection, skin tests or other allergen provocation tests should be completed. In contrast, in animals IgE and dermal tests are regarded as equally important and may even replace each other. However, for practical and economic reasons intradermal tests are most commonly performed in a specialized practice. As in humans, in dogs, cats and horses allergen immunotherapy leads to significant improvement of the clinical symptoms. The collected evidence suggests that canines, felines and equines, with their spontaneous allergies, are attractive model patients for translational studies.

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Group 1 and 2Dermatophagoideshouse dust mite allergens in the microenvironment of cats

Cited by 14 publications

References 40 publications

House dust mite specific in vitro IgE determination in cats with allergic dermatitis

House dust mite specific in vitro IgE determination in cats with allergic dermatitis

The influence of household pets on the composition and quantity of allergenic mite fauna within Irish homes: a preliminary investigation

Pollen Allergies in Humans and their Dogs, Cats and Horses: Differences and Similarities

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