Griffonianone D, an Isoflavone with Anti-inflammatory Activity from the Root Bark of <i>Millettia griffoniana</i>

Yankep, Emmanuel; Njamen, Dieudonné; Fotsing, Maurice Tagatsing; Fomum, Zacharias Tanee; Mbanya, Jean Claude; Giner, Rosa M.; Recio, M. C.; Máñez, Salvador; Rı́os, José Luis

doi:10.1021/np0205912

Cited by 32 publications

(34 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These compounds are known to have phytoestrogenic [209], antioxidant [210,211], anticancer [212], and antinflammatory activities [213]. However, they are present mainly in glycosides form thus decreasing their absorption from small intestine.…”

Section: Applications Based On Hydrolytic Activitymentioning

confidence: 99%

Microbial β-Glucosidases: Screening, Characterization, Cloning and Applications

Ahmed¹,

Aslam²,

Ashraf³

et al. 2017

JAEM

View full text Add to dashboard Cite

Cellulose is the most abundant biomaterial in the biosphere and the major component of plant biomass.Cellulase is an enzymatic system required for conversion of renewable cellulose biomass into free sugar for subsequent use in different applications. Cellulase system mainly consists of three individual enzymes namely: endoglucanase, exoglucanase and β-glucosidases. β-Glucosidases are ubiquitous enzymes found in all living organisms with great biological significance. β-Glucosidases have also tremendous biotechnological applications such as biofuel production, beverage industry, food industry, cassava detoxification and oligosaccharides synthesis. Microbial β-glucosidases are preferred for industrial uses because of robust activity and novel properties exhibited by them. This review aims at describing the various biochemical methods used for screening and evaluating β-glucosidases activity from microbial sources. Subsequently, it generally highlights techniques used for purification of β-glucosidases. It then elaborates various biochemical and molecular properties of this valuable enzyme such as pH and temperature optima, glucose tolerance, substrate specificity, molecular weight, and multiplicity. Furthermore, it describes molecular cloning and expression of bacterial, fungal and metagenomic β-glucosidases. Finally, it highlights the potential biotechnological applications of β-glucosidases.

show abstract

Section: Applications Based On Hydrolytic Activitymentioning

confidence: 99%

Microbial β-Glucosidases: Screening, Characterization, Cloning and Applications

Ahmed¹,

Aslam²,

Ashraf³

et al. 2017

JAEM

View full text Add to dashboard Cite

show abstract

“…(Yankep et al, 2003;Ye et al, 2012). Croton heliotropiifolius Kunth is an endemic specie in the northeast of Brazil frequently found within "caatinga", "brejo", "resting" and "cerrado" vegetations.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical characteristics and cytotoxic effect of the methanolic extract of Croton heliotropiifolius Kunth (Euphorbiaceae)

Silva¹,

Silva²,

Silva³

et al. 2017

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…The genus Millettia (Leguminosae) is a rich source of flavonoids (Baruah et al, 1984;Mahmoud and Waterman, 1985;Sritularak et al, 2002) and isoflavonoids (Palazzino et al, 2003;Yankep et al, 2003;Ito et al, 2004Ito et al, , 2006. Several plants from this genus have yielded several isoflavonoids that exhibited a range of biological and pharmacological activities (Yankep et al, 2003;Ito et al, 2006;Takahashi et al, 2006;Pancharoen et al, 2008), including activity against several cancer cell lines (Ono et al, 1989;Palazzino et al, 2003;Ito et al, 2000Ito et al, , 2004.…”

Section: Introductionmentioning

confidence: 99%

“…Several plants from this genus have yielded several isoflavonoids that exhibited a range of biological and pharmacological activities (Yankep et al, 2003;Ito et al, 2006;Takahashi et al, 2006;Pancharoen et al, 2008), including activity against several cancer cell lines (Ono et al, 1989;Palazzino et al, 2003;Ito et al, 2000Ito et al, , 2004. Millettia leucantha is a deciduous tree with white flowers that is distributed widely in Thailand (Smitinard, 2001) but its pharmaceutical use is unknown.…”

Section: Introductionmentioning

confidence: 99%

A new phenolic compound with anticancer activity from the wood of Millettia leucantha

2011

View full text Add to dashboard Cite

A new phenolic compound, 1-(3-hydroxy-4-methoxyphenyl)-3-(2,4-dihydroxy-5-methoxyphenyl) propan-1-ol, named as millettinol (1), along with six known compounds, medicarpin (2), 4-hydroxy-3-methoxy-8,9-methylenedioxypterocarpan (3), 5,4'-dihydroxy-7,8-dimethoxyisoflavone (4), physcion (5), (R)-(-)-mellein (6) and isoliquiritigenin (7), were isolated from the wood of Millettia leucantha. The structures of the compounds were determined by an analysis of their spectroscopic data. Some of the isolates were tested for anticancer activity. Compound 1 exhibited strong cytotoxicity against the BCA-1 tumor cell lines with an IC(50) = 3.44 μg/mL.

show abstract

Griffonianone D, an Isoflavone with Anti-inflammatory Activity from the Root Bark of Millettia griffoniana

Cited by 32 publications

References 14 publications

Microbial β-Glucosidases: Screening, Characterization, Cloning and Applications

Microbial β-Glucosidases: Screening, Characterization, Cloning and Applications

Physicochemical characteristics and cytotoxic effect of the methanolic extract of Croton heliotropiifolius Kunth (Euphorbiaceae)

A new phenolic compound with anticancer activity from the wood of Millettia leucantha

Contact Info

Product

Resources

About