A new phenolic compound with anticancer activity from the wood of Millettia leucantha

Rayanil, Kanok‐on; Bunchornmaspan, Pastraporn; Tuntiwachwuttikul, Pittaya

doi:10.1007/s12272-011-0603-4

Cited by 32 publications

(17 citation statements)

References 22 publications

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“…It is used for the treatment of respiratory difficulties, constipation, colds and headaches, jaundice as well as some physiological disorders related to menopause [14, 15]. There are also evidences suggesting that plants belonging to the genus Millettia can boost the immune system, and even fight some forms of cancer [16, 17]. Our previous work showed that M. macrophylla dichloromethane (DCM) and methanol (MeOH) extracts have estrogen-like effects on estrogen target organs of ovariectomized Wistar rats and prevent postmenopausal osteoporosis [18, 19].…”

Section: Introductionmentioning

confidence: 99%

Estrogenic and cytotoxic potentials of compounds isolated from Millettia macrophylla Benth (Fabaceae): towards a better understanding of its underlying mechanisms

Zingue

Tchoumtchoua

Ntsa

et al. 2016

BMC Complement Altern Med

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Background Millettia macrophylla was previously reported to have estrogenic effects and to prevent postmenopausal osteoporosis in Wistar rats. So, the study deals with the identification of its secondary metabolites and the evaluation of their estrogenicity and cytotoxicity toward tumoural cells. Thus, 13 known compounds were obtained from successive chromatographic columns and identified by NMR data compared to those previously reported.MethodsIn vitro estrogenicity of the isolates and the phenolic fraction (PF) of M. macrophylla were performed by E-screen and reporter gene assays, while their cytotoxicity was evaluated by Alamar Blue (resazurin) assay. A 3-days uterotrophic assay and the ability of PF to alleviate hot flushes in ovariectomized adult rats were tested in vivo.ResultsSeven of the 13 secondary metabolites turned to be estrogenic. Only two exhibited cytotoxic effects on MCF-7 and MDA-MB-231 with CC50 values of 110 μM and 160 μM, respectively. PF induced a significant (p < 0.01) MCF-7 cells proliferation and transactivated both ERα and ERβ in the reported gene assay at 10−2 μg/mL. In vivo, PF acted more efficiently than the methanol crude extract, resulting to a significant (p < 0.01) increase in the uterine wet weight, uterine protein level, uterine and vaginal epithelial height at the dose of 10 mg/kg BW. In addition, PF reduced the average duration and frequency of hot flushes induced in rat.ConclusionThese aforementioned results indicate that PF is a good candidate for the preparation of an improved traditional medicine able to alleviate some menopausal complaints such as vaginal dryness and hot flushes.Graphical abstractEstrogenic and cytotoxic potentials of compounds isolated from Millettia macrophylla Benth. (Fabaceae): towards a better understanding of its underlying mechanism Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-016-1385-5) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Estrogenic and cytotoxic potentials of compounds isolated from Millettia macrophylla Benth (Fabaceae): towards a better understanding of its underlying mechanisms

Zingue

Tchoumtchoua

Ntsa

et al. 2016

BMC Complement Altern Med

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“…There are several ordinal logistic regression models such as proportional odds model (POM), two versions of the partial proportional odds model-without restrictions (PPOM-UR) and with restrictions (PPOM-R), continuous ratio model (CRM), and stereotype model (SM). The most frequently used ordinal logistic regression model in practice is the constrained cumulative logit model called the proportional odds model [18,33-35]. …”

Section: Introductionmentioning

confidence: 99%

Application of ordinal logistic regression analysis in determining risk factors of child malnutrition in Bangladesh

Das

Rahman²

2011

Nutr J

137

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BackgroundThe study attempts to develop an ordinal logistic regression (OLR) model to identify the determinants of child malnutrition instead of developing traditional binary logistic regression (BLR) model using the data of Bangladesh Demographic and Health Survey 2004.MethodsBased on weight-for-age anthropometric index (Z-score) child nutrition status is categorized into three groups-severely undernourished (< -3.0), moderately undernourished (-3.0 to -2.01) and nourished (≥-2.0). Since nutrition status is ordinal, an OLR model-proportional odds model (POM) can be developed instead of two separate BLR models to find predictors of both malnutrition and severe malnutrition if the proportional odds assumption satisfies. The assumption is satisfied with low p-value (0.144) due to violation of the assumption for one co-variate. So partial proportional odds model (PPOM) and two BLR models have also been developed to check the applicability of the OLR model. Graphical test has also been adopted for checking the proportional odds assumption.ResultsAll the models determine that age of child, birth interval, mothers' education, maternal nutrition, household wealth status, child feeding index, and incidence of fever, ARI & diarrhoea were the significant predictors of child malnutrition; however, results of PPOM were more precise than those of other models.ConclusionThese findings clearly justify that OLR models (POM and PPOM) are appropriate to find predictors of malnutrition instead of BLR models.

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“…Chemical investigations of six chalcones and five flavones have been isolated from the stem bark [2]. Pterocarpans and phenolic compounds have been investigated from stem wood [3,4]. Some isolates show antiviral, anti-plasmodial, anti-cancer and anti-inflammatory activity [2,3,5], whereas the chemical constituents from the fruits have not yet been reported.…”

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confidence: 99%

Flavonoids from Milletia leucantha and Their Cytotoxicity

Sriphana

Yenjai

Tungnoi

et al. 2018

Natural Product Communications

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Two known chalcones (1-2), five known flavonol derivatives (3 and 5-8) and one flavone (4) were isolated for the first time from fruits of Millettia leucantha Kurz. In addition, 5 was found for the first time from this genus. Their structures were elucidated on the basis of IR, MS, 1D and 2D NMR techniques. Chalcone 1 exhibited moderate cytotoxicity against the MCF-7 cell line with an IC 50 value of 50.93 µM, whereas this compound showed inactive cytotoxicity against Vero cells. Compound 2 exhibited cytotoxicity against the KB, NCI-H187 and Vero cell lines with IC 50 values of 63.64, 114.44 and 28.44 µM, respectively. Compound 8 only showed cytotoxic activity against the KB cell line with an IC 50 value of 110.23 µM.

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A new phenolic compound with anticancer activity from the wood of Millettia leucantha

Cited by 32 publications

References 22 publications

Estrogenic and cytotoxic potentials of compounds isolated from Millettia macrophylla Benth (Fabaceae): towards a better understanding of its underlying mechanisms

Estrogenic and cytotoxic potentials of compounds isolated from Millettia macrophylla Benth (Fabaceae): towards a better understanding of its underlying mechanisms

Application of ordinal logistic regression analysis in determining risk factors of child malnutrition in Bangladesh

Flavonoids from Milletia leucantha and Their Cytotoxicity

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