Flavonoids from <i>Milletia leucantha</i> and Their Cytotoxicity

Sriphana, Uraiwan; Yenjai, Chavi; Tungnoi, Siriporn; Srirapa, Jongjai; Junsongduang, Auemporn

doi:10.1177/1934578x1801300810

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…On the other hand, this abundant production of LDH in the extracellular medium was not observed with the compounds Chal_B14, Chal_B17 and Chal_SCA03. These results corroborate with those of Sriphana et al [25] which evaluated the cytotoxicity of two chalcones isolated for the first time from fruits of Millettia leucantha on Vero cells. Similarly, Rizvi et al evaluated the anti-HIV1 and cytotoxic activities of piperidyl-thienyl chalcones and their 2-pyrazoline derivatives on PBM, CEM and Vero cells.…”

Section: Compoundssupporting

confidence: 91%

Evaluation of Cytotoxic Profile of Some Chalcone Derivatives with Antimalarial Properties

Dable

Ouattara

Adjogoua

et al. 2020

CSIJ

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Malaria continues to kill thousands of people worldwide. People South of the Sahara are paying the heaviest price for this epidemic. In addition, the resistance of Plasmodium falciparum which spreads to artemisinin derivatives becomes worrying. To respond to this emergency, the search for new molecules effective against the parasite is essential. Otherwise, chalcones have shown their potential as an effective pharmaceutical agent in numerous studies. However, despite their mainly antiparasitic efficacy, several compounds have been shown to be cytotoxic. This study aimed to assess the cytotoxic profile of chalcone derivatives. Cytotoxicity tests were carried out according to the method described by Taylor and collaborators on Vero cells. The 96-well plates were used in carrying out this study, 100 µl of the compounds were added with concentrations ranging from 7.5 to 1000 µg/ml in DMEM. The results obtained report three compounds derivatives (Chal_B14, Chal_B17 & Chal_SCA03) no-cytotoxic with LDH product values between 129 - 132.5 U/L and ATP ranging from 8.55 to 13.6 RLU. The IC50s for no-cytotoxic compounds ranged from 102 to 236 µM. On the other hand, the cytotoxic compounds had IC50s of less than 30 µM. The results of this study show that the derivatives Chal_B14, Chal_B17 & Chal_SCA03 are candidate compounds with a view to finding new molecules.

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Section: Compoundssupporting

confidence: 91%

Evaluation of Cytotoxic Profile of Some Chalcone Derivatives with Antimalarial Properties

Dable

Ouattara

Adjogoua

et al. 2020

CSIJ

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“…The samples were filtered through Whatman No. 1 filter paper (GE Healthcare Life Sciences, USA), and the liquid fractions were concentrated with rotary evaporator to obtain the crude extracts [25, 26]. Each methanol extract was lyophilized and stored in a moisture-free desiccator until use.…”

Section: Methodsmentioning

confidence: 99%

Preliminary analysis of a neotropical plant extract antiviral potential against Chikungunya and Mayaro viruses

Pires

Silva

Schallenberger

et al. 2021

Preprint

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Chikungunya and Mayaro fevers are viral infectious diseases, without vaccine or treatment, that causes fever and arthralgia. Establishing novel antiviral tools capable of preventing or treating Chikungunya virus (CHIKV), and Mayaro virus (MAYV) infections are needed. The use of plant-based compounds that affect the replication cycles of these viruses has been proposed as a promising strategy. Chiococca alba (L.) Hitchc. is a neotropical plant used by Yucatec Mayas traditional healers, mainly, as antipyretic and antirheumatic. To evaluate the potential of C. alba methanolic extracts against CHIKV and MAYV through preliminary analysis in vitro and in silico . The cytotoxicity profile of two C. alba roots methanolic extracts in Vero cells was performed by lysosomal viability using the neutral red assay, and the antiviral potential was determined by plaque assay. We further assessed, through in silico computational predictions, the possible interactions between the active site of the nsP2 proteases of these viruses with some secondary metabolites present in C. alba extracts, identified by High-Performance Liquid Chromatography (HPLC). Our partial phytochemical analysis revealed the presence of flavonoids, and phenolic acids in the C. alba extracts. Our in vitro assays showed that both C. alba extracts inhibited more than 70% of CHIKV and MAYV activities at 60 µg/mL concentration. Based on our in silico computational predictions, the flavonoids naringin and vitexin showed the greatest affinity energies with the CHIKV and MAYV nsP2 proteases, revealing the great potential of these compounds as viral inhibitors. The findings described here indicates that C. alba extracts, or their secondary metabolites, as a potential source of novel antiviral compounds.

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Flavonoids from Milletia leucantha and Their Cytotoxicity

Cited by 2 publications

References 13 publications

Evaluation of Cytotoxic Profile of Some Chalcone Derivatives with Antimalarial Properties

Evaluation of Cytotoxic Profile of Some Chalcone Derivatives with Antimalarial Properties

Preliminary analysis of a neotropical plant extract antiviral potential against Chikungunya and Mayaro viruses

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