Griffipavixanthone, a novel cytotoxic bixanthone from Garcinia griffithii and G. pavifolia

Xu, Yuan; Cao, Shugeng; Wu, Xiaohua; Lai, Yongqing; Tan, B.H.K.; Pereira, Joan T.; Goh, S. H.; Venkatraman, Ganapathi; Harrison, Leslie J.; Sim, Keng‐Yeow

doi:10.1016/s0040-4039(98)02007-3

Cited by 37 publications

(40 citation statements)

References 7 publications

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“…The polyisoprenylated benzophenones cambogin or isoxanthochymol, and guttiferone I, as well as the xanthones 1,7-dihydroxyxanthone, 1,3,6,7-tetrahydroxyxanthone, 1,3,5,6-tetrahydroxyxanthone, 1,5-dihydroxy-3,6-dimethoxy-2,7-diprenylxanthone, 1,6-dihydroxyxanthone and a bixanthone, griffipavixanthone, have been isolated and identified from G. griffithii [8,9]. The current phytochemical study provides different skeletons of metabolites as compared to the previous studies.…”

Section: Resultsmentioning

confidence: 99%

“…The current phytochemical study provides different skeletons of metabolites as compared to the previous studies. Elfita et al [21] [8].…”

Section: Resultsmentioning

confidence: 99%

“…To date, there are three reports on the phytochemicals of G. griffithii collected from Singapore (2005) [7] and Indonesia (2006,2009) [8][9]. However, the bioactivities of the plants are not studied thoroughly.…”

Section: Introductionmentioning

confidence: 99%

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Biflavonoids from the leaves and stem bark of Garcinia griffithii and their biological activities

Salleh¹,

Sazali²,

Ahmad³

et al. 2017

mpj

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The phytochemical and biological activity of the leaves and stem barks of Garcinia griffithii have been investigated. Extraction and chromatographic purification of the leaves and stem barks extracts have successfully afforded five biflavonoids namely amento-4''-methylether (1), 3,8''-binaringenin (2), morelloflavone (3), 3,8''-binaringenin-7''-O-glucoside (4) and morelloflavone-7''-Oglucoside (5), together with squalene (6), canophyllol (7), friedelin (8) and β-amyrin (9) which were characterized spectroscopically.All extracts and phytochemicals were tested for antioxidant, antityrosinase and antibacterial activities. The antioxidant assay on DPPH radical scavenging showed that the n-hexane extract of the stem barks had the highest radical scavenging activity with IC 50 value of 96.4 μg/mL, while compound (3) was found to be the strongest antioxidant compound with IC 50 value of 57.6 μg/mL. The methanol extract of the leaves showed the highest total phenolic content with 444.1 mg/g of gallic acid equivalent (GAE/L) and 423.1 mg/g of cathechin equivalent (CE/L). The extracts and all compounds were found to have weak antityrosinase activity. The antimicrobial assays of all the extracts were carried out by minimum inhibition concentration (MIC) and minimum bactericidal concentration (MBC). The methanol extract of the leaves showed the most significant antimicrobial activity towards E. faecalis and K. pneumoniae with MIC and MBC value ranged between 225-450 μg/mL compared to the other extracts.

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Section: Resultsmentioning

confidence: 99%

“…The current phytochemical study provides different skeletons of metabolites as compared to the previous studies. Elfita et al [21] [8].…”

Section: Resultsmentioning

confidence: 99%

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Biflavonoids from the leaves and stem bark of Garcinia griffithii and their biological activities

Salleh¹,

Sazali²,

Ahmad³

et al. 2017

mpj

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“…A substantial number of studies on the antitumor activities of Garcinia species have been reported and their activities were often attributed to the presence of xanthones, triterpenes, depsidones and benzophenones Xu et al, 1998Xu et al, , 2000Mackeen et al, 2000;Thoison et al, 2000;Matsumoto et al, 2003b). The chemopreventive effects of xanthones and benzophenones from G. assigu and G. fusca were also reported .…”

Section: Discussionmentioning

confidence: 99%

“…(Likhitwitayawuid et al, 1998) and Garcinia parvifolia Miq. (Xu et al, 1998;Rukachaisirikul et al, 2008). We have recently reported the cytotoxic constituents from Garcinia penangiana Pierre , Garcinia urophylla Scortech.ex King and Garcinia cantleyana T.C.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic and nitric oxide inhibitory activities of methanol extracts ofGarciniaspecies

Jabit¹,

Wahyuni²,

Khalid³

et al. 2009

Pharmaceutical Biology

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ChemInform Abstract: Griffipavixanthone, a Novel Cytotoxic Bixanthone from Garcinia griffithii and G. pavifolia.

Cao

et al. 1999

ChemInform

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Griffipavixanthone, a novel cytotoxic bixanthone from Garcinia griffithii and G. pavifolia

Cited by 37 publications

References 7 publications

Biflavonoids from the leaves and stem bark of Garcinia griffithii and their biological activities

Biflavonoids from the leaves and stem bark of Garcinia griffithii and their biological activities

Cytotoxic and nitric oxide inhibitory activities of methanol extracts ofGarciniaspecies

ChemInform Abstract: Griffipavixanthone, a Novel Cytotoxic Bixanthone from Garcinia griffithii and G. pavifolia.

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