Grey matter abnormalities in untreated hyperthyroidism: A voxel-based morphometry study using the DARTEL approach

Zhang, Wei; Song, Lingheng; Yin, Xuntao; Zhang, Jiuquan; Liu, Chen; Wang, Jian; Zhou, Dan; Chen, Bing; Lii, Haitao

doi:10.1016/j.ejrad.2013.09.019

Cited by 52 publications

(55 citation statements)

References 29 publications

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“…VBM did not reveal any gray matter differences in patients compared to controls, but fT 4 levels in the patients were within the normal range. A study in adult patients with long-standing hyperthyroidism with clinical symptoms [14] revealed reduced GMV in the hippocampus, parahippocampal gyrus, calcarine region, lingual gyrus and left temporal pole, and increased GMV in the supplementary motor area bilaterally. Again, no differences were seen for the cerebellum.…”

Section: Discussionmentioning

confidence: 99%

“…With regard to morphological changes, there has been a recent study using voxel-based morphometry (VBM) analysis [14] that investigated a large group of 51 patients suffering from hyperthyroidism and reported altered gray matter volumes (GMV) in a number of brain regions (see Discussion). As stated above, the use of patients might be problematic, as a number of reports have suggested an autoimmune component contributing to neurological/neuropsychological symptoms in Graves' disease [17,18] .…”

Section: Introductionmentioning

confidence: 99%

“…It is known that hyperthyroidism leads to involvement of the central nervous system, including clinical symptoms such as reduced concentration and memory performance, nervousness, irritability, and tremulousness [7,14,15] . However, these studies have mostly been obtained in clinical populations and thus a number of confounds, such as the direct impact of autoimmune disease on the brain, have to be considered.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Experimental Thyrotoxicosis on Brain Gray Matter: A Voxel-Based Morphometry Study

et al. 2015

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Background: Hyper- as well hypothyroidism have an effect on behavior and brain function. Moreover, during development thyroid hormones influence brain structure. Objectives: This study aimed to demonstrate an effect of experimentally induced hyperthyroidism on brain gray matter in healthy adult humans. Methods: High-resolution 3D T1-weighted images were acquired in 29 healthy young subjects prior to as well as after receiving 250 µg of T4 per day for 8 weeks. Voxel-based morphometry analysis was performed using Statistical Parametric Mapping 8 (SPM8). Results: Laboratory testing confirmed the induction of hyperthyroidism. In the hyperthyroid condition, gray matter volumes were increased in the right posterior cerebellum (lobule VI) and decreased in the bilateral visual cortex and anterior cerebellum (lobules I-IV) compared to the euthyroid condition. Conclusions: Our study provides evidence that short periods of hyperthyroidism induce distinct alterations in brain structures of cerebellar regions that have been associated with sensorimotor functions as well as working memory in the literature.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of Experimental Thyrotoxicosis on Brain Gray Matter: A Voxel-Based Morphometry Study

et al. 2015

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“…First, VBM has inherent limitations including “methodological and parameter choices in segmentation, registration, and correction for multiple comparisons, that may heavily vary and influence the results”30. VBM is highly sensitive to the performance of the registration and segmentation process, that is, deformation inaccuracy or misregistration may influence the results3132.…”

Section: Discussionmentioning

confidence: 99%

Sex-related difference in human white matter volumes studied: Inspection of the corpus callosum and other white matter by VBM

Shiino

Chen

Tanigaki

et al. 2017

Sci Rep

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It has been contended that any observed difference of the corpus callosum (CC) size between men and women is not sex-related but brain-size-related. A recent report, however, showed that the midsagittal CC area was significantly larger in women in 37 brain-size-matched pairs of normal young adults. Since this constituted strong evidence of sexual dimorphism and was obtained from publicly available data in OASIS, we examined volume differences within the CC and in other white matter using voxel-based morphometry (VBM). We created a three-dimensional region of interest of the CC and measured its volume. The VBM statistics were analyzed by permutation test and threshold-free cluster enhancement (TFCE) with the significance levels at FWER < 0.05. The CC volume was significantly larger in women in the same 37 brain-size-matched pairs. We found that the CC genu was the subregion showing the most significant sex-related difference. We also found that white matter in the bilateral anterior frontal regions and the left lateral white matter near to Broca’s area were larger in women, whereas there were no significant larger regions in men. Since we used brain-size-matched subjects, our results gave strong volumetric evidence of localized sexual dimorphism of white matter.

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“…Thyroid receptors are concentrated in the limbic system that is responsible for memory. Hyperthyroid patients exhibited grey matter changes primarily in the areas associated with cognitive, emotional and behavioural abnormalities 20. The role of thiamine deficiency in the genesis of neuropsychiatric symptoms associated with hyperthyroidism has not been studied.…”

Section: Discussionmentioning

confidence: 99%

Wernicke’s encephalopathy secondary to gestational hyperthyroidism

Garla¹,

Yanes-Cardozo

Yousuf

et al. 2017

BMJ Case Reports

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Grey matter abnormalities in untreated hyperthyroidism: A voxel-based morphometry study using the DARTEL approach

Cited by 52 publications

References 29 publications

Effect of Experimental Thyrotoxicosis on Brain Gray Matter: A Voxel-Based Morphometry Study

Effect of Experimental Thyrotoxicosis on Brain Gray Matter: A Voxel-Based Morphometry Study

Sex-related difference in human white matter volumes studied: Inspection of the corpus callosum and other white matter by VBM

Wernicke’s encephalopathy secondary to gestational hyperthyroidism

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