Green tea supplementation promote leukocyte telomere length elongation in obese women

Nonino, Carla Barbosa; Pinhanelli, Vitor Caressato; Noronha, Natália Yumi; Quinhoneiro, Driele Cristina Gomes; Pinhel, Marcela Augusta Souza; Oliveira, Bruno Affonso Parenti de; Marchini, Júlio Sérgio; Nicoletti, Carolina Ferreira

doi:10.20960/nh.1392

Cited by 7 publications

(12 citation statements)

References 34 publications

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“…Another study by Nonino, et al [23] found a positive relationship between telomere length and drinking green tea in obese women. After an 8-week period of drinking green tea, obese women showed a significant increase in telomere length compared to telomere length before the intervention; effect that can be explained due to the antioxidant components present in green tea, such as flavonoids and mainly epigallocatechin-3-gallate (EGCG) [23]. Some nutrients have also been shown to increase telomere length, notably omega-3 fatty acids, vitamins, and minerals.…”

Section: Dietmentioning

confidence: 93%

“…For every 10g of fiber (per 1000 kcal) consumed, telomeres were 67 base pairs longer equivalent to 4.3 years less of aging [22]. Another study by Nonino, et al [23] found a positive relationship between telomere length and drinking green tea in obese women. After an 8-week period of drinking green tea, obese women showed a significant increase in telomere length compared to telomere length before the intervention; effect that can be explained due to the antioxidant components present in green tea, such as flavonoids and mainly epigallocatechin-3-gallate (EGCG) [23].…”

Section: Dietmentioning

confidence: 96%

“…Sedentary behavior and obesity have also been associated with a negative effect on telomere length [23,42]. In this way, it is crucial to control Body Mass Index, prevent obesity, and reduce sedentary habits.…”

Section: Sedentary Lifestyle and Obesitymentioning

confidence: 99%

“…r r e c t e d A u t h o r P r o o fand aging[23, 40]. Sedentary behavior has been related to reduced mitochondrial activity (an important determinant of biological aging).…”

mentioning

confidence: 99%

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Lifestyle effects on telomeric shortening as a factor associated with biological aging: A systematic review

Espinosa-Otalora

Flórez-Villamizar

Esteban-Pérez

et al. 2020

NHA

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BACKGROUND: Telomeres are structures located at the chromosome ends, whose function is protecting DNA from attrition caused during cell division. Telomeric length serves as a mitotic clock, activating senescence and cellular cycle arrest when it reaches a shortening limit, which causes aging. Lifestyle is a factor that can affect telomeric shortening. Unhealthy habits have been linked to accelerated telomeric shortening, while healthy lifestyles are known to reduce this process and slow down aging. Current community has expressed an interest in improving lifestyle choices; however, an increase in unhealthy habits and chronic stressors have been seen. OBJECTIVE: This review aims to show the influence that different lifestyles have on telomeric length. METHODS: The review was carried out following the PRISMA statement in three databases. Twenty-eight research articles and nine review articles were reviewed, identifying six main lifestyles habits. RESULTS: Regular moderate-vigorous physical activity, dietary patterns rich in vegetables and antioxidants, and the stress control techniques were related to greater telomeric lengths and improvements in the oxidative response by reducing the levels of oxidative stress markers. On the contrary, stress, obesity, smoking, and alcoholism showed a negative effect of shorter telomeres, which can be a factor of early aging. CONCLUSION: The previous demonstrates the influences of lifestyles on telomere shortening rates and aging, therefore they should be considered as areas of interest for future research, and personal and community health improvement.

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Section: Dietmentioning

confidence: 93%

Section: Dietmentioning

confidence: 96%

Section: Sedentary Lifestyle and Obesitymentioning

confidence: 99%

“…r r e c t e d A u t h o r P r o o fand aging[23, 40]. Sedentary behavior has been related to reduced mitochondrial activity (an important determinant of biological aging).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Lifestyle effects on telomeric shortening as a factor associated with biological aging: A systematic review

Espinosa-Otalora

Flórez-Villamizar

Esteban-Pérez

et al. 2020

NHA

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“…Green tea boosts leukocyte telomere length elongation in obese women. Telomere length and BMI showed an inverse association [ 52 ].…”

Section: Mediterranean Diet’s Impact On Epigenetic Mechanismsmentioning

confidence: 99%

Mediterranean Diet as a Tool to Combat Inflammation and Chronic Diseases. An Overview

et al. 2020

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Since ancient times, the quality of nourishment is a milestone for the maintenance of health and as it is stated ‘prevention is better than cure’, amongst the so-called ‘healthy’ diets Mediterranean diet (MD) claims the lion’s share. It stands in good stead because of a variety of valuable macro- and micronutrients. So, adherence to a MD is associated with the reduction of inflammation and non-communicable (NCD) OR chronic diseases. Numerous studies try to scrutinize the role of MD components as regards reducing inflammation, lowering rate, and mortality for disorders and illnesses, and preventing NCD. MD regime of the inhabitants of the Mediterranean basin includes a variety of ethnic nutritional habits and regulates an array of effects and epigenetic changes that affect human wellbeing. The research is still ongoing and endeavors to elucidate every aspect of this issue. This review focuses on the impact of MD on inflammation highlights positive results regarding NCD and indicates the need for more high-quality experiments and trials in order to overcome any discrepancies.

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Efficacy of a dietary supplement derived from five edible plants on telomere length in Thai adults: A randomized, double‐blind, placebo‐controlled trial

Praengam,

Tuntipopipat,

Muangnoi

et al. 2023

Food Science & Nutrition

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Mylife/Mylife100® is a dietary supplement consisting of black sesame seed, guava fruit, mangosteen aril, pennywort leaves, and soy protein. These edible plants contain multiple high‐potential bioactive compounds exerting various vital biological functions including antioxidants which contribute to delaying the rate of telomere shortening. Telomere length is associated with cellular aging and age‐related diseases. This study aimed to assess the efficacy of Mylife/Mylife100® on telomere length through a randomized, double‐blind placebo‐controlled trial. The trial assessed the alteration of leukocyte telomere length after 32 adults aged 50–65 years received either Mylife/Mylife100® or placebo (five capsules/day) for 8‐week supplementation. The results demonstrated a significant increase in mean telomere length from baseline (6313 bp) to the 8‐week supplementation period (6655 bp; p < 0.05) in the group receiving the product, whereas no significant change was observed in the placebo group. Additionally, the product group exhibited a significant improvement in plasma total antioxidant capacity levels compared to the placebo group (mean change, +35 vs −38; p = 0.006). This study also showed a significant correlation between telomere length and % CD4 + T cells (r = +0.325; p = 0.00003), % CD8 + T cells (r = +0.156; p = 0.048), and visceral fat (r = − 0.349; p = 0.000006). The findings suggest that consuming this dietary supplement (Mylife/Mylife100®) for 8 weeks has a positive effect on cellular aging by lengthening telomeres possible through their antioxidant capacities. Oxidative stress and cellular aging are underlying predisease mechanisms that might be alleviated by supplementing with this product.

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Green tea supplementation promote leukocyte telomere length elongation in obese women

Abstract: obesity is related to shorter telomeres. Green tea supplementation during eight weeks promotes telomere elongation in obese women.

Cited by 7 publications

References 34 publications

Lifestyle effects on telomeric shortening as a factor associated with biological aging: A systematic review

Lifestyle effects on telomeric shortening as a factor associated with biological aging: A systematic review

Mediterranean Diet as a Tool to Combat Inflammation and Chronic Diseases. An Overview

Efficacy of a dietary supplement derived from five edible plants on telomere length in Thai adults: A randomized, double‐blind, placebo‐controlled trial

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