Green tea polyphenols and epigallocatechin-3-gallate protect against perfluorodecanoic acid induced liver damage and inflammation in mice by inhibiting NLRP3 inflammasome activation

Wang, Dongxu; Gao, Qiang; Wang, Taotao; Kan, Zhipeng; Li, Xin; Hu, Lingyun; Peng, Chuanyi; Qian, Frank; Wang, Yijun; Granato, Daniel

doi:10.1016/j.foodres.2019.108628

Cited by 51 publications

(26 citation statements)

References 55 publications

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“…The NLRP3 inflammasome has been implicated in a wide range of diseases, including AP, diabetes and prion and neurodegenerative diseases [ 22 ]. Studies have demonstrated that various natural compounds can ameliorate inflammation by inhibiting the NLRP3 pathway [ 23 ]. Natural compounds with the capacity to modulate the activation of NLRP3 may thus be considered as complementary treatments in acute and chronic inflammatory disorders.…”

Section: Introductionmentioning

confidence: 99%

Cashew (Anacardium occidentale L.) Nuts Modulate the Nrf2 and NLRP3 Pathways in Pancreas and Lung after Induction of Acute Pancreatitis by Cerulein

et al. 2020

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Background: One of the most common co-morbidities, that often leads to death, associated with acute pancreatitis (AP) is represented by acute lung injury (ALI). While many aspects of AP-induced lung inflammation have been investigated, the involvement of specific pathways, such as those centered on nuclear factor E2-related factor 2 (Nrf2) and nucleotide-binding domain leucine-rich repeat (NLR) and pyrin domain containing receptor 3 (NLRP3), has not been fully elucidated. Methods: To investigate the effect of cashew (Anacardium occidentale L.) nuts on pancreatic and lung injury induced by cerulein injection, cerulein (50 μg/kg) was administered to CD1 mice for 10 h. Oral treatment with cashew nuts at a dose of 100 mg/kg was given 30 min and 2 h after the first cerulein injection. One hour after the final cerulein injection, mice were euthanized and blood, lung and pancreatic tissue samples were collected. Results: Cashew nuts were able to (1) reduce histological damage; (2) mitigate the induction of mast cell degranulation as well as the activity of myeloperoxidase and malondialdehyde; (3) decrease the activity levels of amylase and lipase as well as the levels of pro-inflammatory cytokines; and (4) enhance the activation of the Nrf2 pathway and suppress the activation of the NLRP3 pathway in response to cerulein in both pancreas and lung. Conclusions: Cashew nuts could have a beneficial effect not only on pancreatitis but also on lung injury induced by cerulein.

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Section: Introductionmentioning

confidence: 99%

Cashew (Anacardium occidentale L.) Nuts Modulate the Nrf2 and NLRP3 Pathways in Pancreas and Lung after Induction of Acute Pancreatitis by Cerulein

et al. 2020

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“…Oral or intravenous infusion of EGCG could reduce mRNA and protein expression of renal NLRP3 in lupus nephritis mouse model and contrast-induced nephropathy rat model, possibly leading to the reduction of NLRP3 inflammasome activation [ 61 , 72 ]. In mice with PFDA-induced liver damage and inflammation, GTPs or EGCG extended the survival time, inhibited weight loss, improved hepatic oxidative stress, cell apoptosis, steatosis, edema, necrosis, and degeneration, reduced hepatic inflammation and NLRP3 inflammasome activation [ 73 ].…”

Section: Immunomodulation Through Anti-inflammatory Mechanismmentioning

confidence: 99%

Immunomodulatory Effects of Green Tea Polyphenols

Wang

et al. 2021

Molecules

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Green tea and its bioactive components, especially polyphenols, possess many health-promoting and disease-preventing benefits, especially anti-inflammatory, antioxidant, anticancer, and metabolic modulation effects with multi-target modes of action. However, the effect of tea polyphenols on immune function has not been well studied. Moreover, the underlying cellular and molecular mechanisms mediating immunoregulation are not well understood. This review summarizes the recent studies on the immune-potentiating effects and corresponding mechanisms of tea polyphenols, especially the main components of (–)-epigallocatechin-3-gallate (EGCG) and (–)-epicatechin-3-gallate (ECG). In addition, the benefits towards immune-related diseases, such as autoimmune diseases, cutaneous-related immune diseases, and obesity-related immune diseases, have been discussed.

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“…As natural polyphenolic phytochemicals that exist primarily in tea, tea polyphenols have been shown to have many clinical applications [10,11]. Tea polyphenols could protect tri-ortho-cresyl phosphate-induced ovarian damage via inhibiting oxidative stress [12] and ameliorate hepatic oxidative stress though reducing hepatic inflammation and NLRP3 inflammasome activation caused by a moderate dose of perfluorodecanoic acid [13]. Additionally, it can not only regulate the antioxidant enzyme system in the body and play an efficient scavenging effect on free radicals by activating the Nrf2/Keap1 pathway [9,14] but also inhibit the oxidase system in the body, such as inhibiting the production of NADPH oxidase, to reduce the production of ROS in vascular endothelium and protect the heart [9,15].…”

Section: Tcm-based Bioactive Compounds Andmentioning

confidence: 99%

Effects of Traditional Chinese Medication‐Based Bioactive Compounds on Cellular and Molecular Mechanisms of Oxidative Stress

Liang

Zhu

et al. 2021

Oxidative Medicine and Cellular Longevity

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The oxidative stress reaction is the imbalance between oxidation and antioxidation in the body, resulting in excessive production of oxygen free radicals in the body that cannot be removed, leading to excessive oxidation of the body, and causing damage to cells and tissues. A large number of studies have shown that oxidative stress is involved in the pathological process of many diseases, so inhibiting oxidative stress, that is, antioxidation, is of great significance for the treatment of diseases. Studies have shown that many traditional Chinese medications contain antioxidant active bioactive compounds, but the mechanisms of those compounds are different and complicated. Therefore, by summarizing the literature on antioxidant activity of traditional Chinese medication-based bioactive compounds in recent years, our review systematically elaborates the main antioxidant bioactive compounds contained in traditional Chinese medication and their mechanisms, so as to provide references for the subsequent research.

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Green tea polyphenols and epigallocatechin-3-gallate protect against perfluorodecanoic acid induced liver damage and inflammation in mice by inhibiting NLRP3 inflammasome activation

Cited by 51 publications

References 55 publications

Cashew (Anacardium occidentale L.) Nuts Modulate the Nrf2 and NLRP3 Pathways in Pancreas and Lung after Induction of Acute Pancreatitis by Cerulein

Cashew (Anacardium occidentale L.) Nuts Modulate the Nrf2 and NLRP3 Pathways in Pancreas and Lung after Induction of Acute Pancreatitis by Cerulein

Immunomodulatory Effects of Green Tea Polyphenols

Effects of Traditional Chinese Medication‐Based Bioactive Compounds on Cellular and Molecular Mechanisms of Oxidative Stress

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