Green tea polyphenol tailors cell adhesivity of RGD displaying surfaces: multicomponent models monitored optically

Péter, Beatrix; Farkas, Enikő; Forgacs, Eniko; Saftics, András; Kovács, Boglárka; Kurunczi, Sándor; Székács, Inna; Csámpai, Antal; Bősze, Szilvia; Horváth, Róbert

doi:10.1038/srep42220

Cited by 53 publications

(121 citation statements)

References 66 publications

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“…Several studies have shown that EGCG can bind to laminin (Peter et al, 2017;Suzuki and Isemura, 2001) and disturb the adhesion of cells to the extracellular matrix (Bracke et al, 1987;Chen et al, 2003;Suzuki and Isemura, 2001) finally leading to an altered cell migration pattern (Bal-Price et al, 2017;Barenys et al, 2017a;Nyffeler et al, 2017). The structural moieties inducing this altered cell migration seemed to be galloyl/pyrogallol groups because in a previous study, catechins lacking these residues did not disrupt cell adhesion (Barenys et al, 2017a).…”

Section: Egcg ≈ G37 > M2 > M1 ≈ G56 > Nano-egcgmentioning

confidence: 90%

Comparison of migration disturbance potency of epigallocatechin gallate (EGCG) synthetic analogs and EGCG PEGylated PLGA nanoparticles in rat neurospheres

Kühne

Puig

Ruiz‐Martínez

et al. 2019

Food and Chemical Toxicology

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Epigallocatechin gallate (EGCG), the main catechin of green tea, is described to have potential health benefits in several fields like oncology, neurology or cardiology. Currently, it is also under pre-clinical investigation as a potential therapeutic or preventive treatment during pregnancy against developmental adverse effects induced by toxic substances. However, the safety of EGCG during pregnancy is unclear due to its proven adverse effects on neural progenitor cells' (NPCs) migration. As lately several strategies have arisen to generate new therapeutic agents derived from EGCG, we have used the rat 'Neurosphere Assay' to characterize and compare the effects of EGCG structurally related compounds and EGCG PEGylated PLGA nanoparticles on a neurodevelopmental key event: NPCs migration. Compounds structurally-related to EGCG induce the same pattern of NPCs migration alterations (decreased migration distance, decreased formation of migration corona, chaotic orientation of cellular processes and decreased migration of neurons at higher concentrations). The potency of the compounds does not depend on the number of galloyl groups, and small structure variations can imply large potency differences. Due to their lower toxicity observed in vitro in NPCs, 4,4,5trihydroxybenzoyl)oxy]-1,1'-biphenyl and EGCG PEGylated PLGA nanoparticles are suggested as potential future therapeutic or preventive alternatives to EGCG during prenatal period.

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Section: Egcg ≈ G37 > M2 > M1 ≈ G56 > Nano-egcgmentioning

confidence: 90%

Comparison of migration disturbance potency of epigallocatechin gallate (EGCG) synthetic analogs and EGCG PEGylated PLGA nanoparticles in rat neurospheres

Kühne

Puig

Ruiz‐Martínez

et al. 2019

Food and Chemical Toxicology

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“…EGCGs can be adsorbed onto the polymeric layer of poly(l‐lysine)‐graft‐PEGs functionalized with Arg‐Gly‐Asp (RGD sequences for cell adhesion) via hydrogen bonds . The binding affinity of oxidized EGCGs is higher than that of nonoxidized EGCGs.…”

Section: Surface Engineering Strategies Using Pyrogallol Materialsmentioning

confidence: 99%

Plant‐Inspired Pyrogallol‐Containing Functional Materials

Shin

Park

Lee

2019

Adv Funct Materials

152

106

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Pyrogallol-containing molecules are ubiquitous in the plant kingdom. The chemical synthesis of these molecules remains challenging. Thus, they are obtained via purification from heterogeneous mixtures of plant extracts. Previous studies have focused on their biological roles, such as antioxidants. Additionally, the molecules are used as ink colorants and in tanning processes for leather. Recently, many disciplines have paid attention to adhesiveness of pyrogallol-containing molecules, including the control of interface properties in energy storage/generation and medical devices, as well as the changes in wettability related to membrane technologies. In particular, pyrogallol-containing molecules act as "molecular glues," binding to virtually all biomacromolecules, for example, DNA/RNA, soluble proteins, insoluble extracellular matrices, and peptides. Furthermore, the cohesion of pyrogallol by forming pyrogallol-to-pyrogallol covalent bonds is useful for the preparation of bulk hydrogels and thin films. The content of this review focuses on interactions with biomacromolecules used as molecular glues, used as modifiers in material-independent surface chemistry, and applied as chemical moieties to form covalent linkages to fabricate hydrogels and related biomaterials. Future perspectives include the development of new pyrogallol-containing materials, the understanding of chirality in adhesion, and the improvement of the mechanical stability for applications in various biomedical, energy, and industrial devices. molecules, strategies for surface modifications, and biomedical applications (Figure 1). Based on the timeline of pyrogallol research, we begin by describing the basic physicochemical properties of pyrogallol analogs, focusing on intermolecular interactions with macromolecules. Section 2 introduces the chemical versatility of pyrogallol analogs in macromolecular complexation, and analytical methods for the complexation are explained. Furthermore, the biological functions of pyrogallol analogs, particularly their therapeutic effects on cancers and inflammatory diseases, are explained. Next, surface modification strategies using pyrogallol-containing molecules are explained (Section 3). We discuss pyrogallol-derived formulations for biomedical purposes, ranging from hydrogels to particles (Section 4). Finally, we conclude with an outlook for the further development and implementation of natural pyrogallol analogs and pyrogallol-conjugated synthetic polymers. This review will be helpful for understanding past studies and current progress in pyrogallol-containing molecules research and for predicting future perspectives. Chemical and Structural Analysis of Colloidal ComplexationEarly uses largely involved intermolecular interactions between pyrogallol analogs and proteins. Pyrogallol analog complexations were particularly effective in studies of proline-rich proteins (PRPs)

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“…problem not yet solved. However, they have clear advantages when the biomolecular adsorption, prior to the adhesion of living cells, has to be also recorded in a single experiment [55].…”

Section: Molecular Force Sensors [50] Inside Cells Based On Förster Rmentioning

confidence: 99%

A practical review on the measurement tools for cellular adhesion force

Ungai-Salánki

Péter

Gerecsei

et al. 2019

Advances in Colloid and Interface Science

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Cell-cell and cell-matrix adhesions are fundamental in all multicellular organisms. They play a key role in cellular growth, differentiation, pattern formation and migration. Cell-cell adhesion is substantial in the immune response, pathogen-host interactions, and tumor development. The success of tissue engineering and stem cell implantations strongly depends on the fine control of live cell adhesion on the surface of natural or biomimetic scaffolds. Therefore, the quantitative and precise measurement of the adhesion strength of living cells is critical, not only in basic research but in modern technologies, too. Several techniques have been developed or are under development to quantify cell adhesion. All of them have their pros and cons, which has to be carefully considered before the experiments and interpretation of the recorded data. Current review provides a guide to choose the appropriate technique to answer a specific biological question or to complete a biomedical test by measuring cell adhesion.

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Green tea polyphenol tailors cell adhesivity of RGD displaying surfaces: multicomponent models monitored optically

Cited by 53 publications

References 66 publications

Comparison of migration disturbance potency of epigallocatechin gallate (EGCG) synthetic analogs and EGCG PEGylated PLGA nanoparticles in rat neurospheres

Comparison of migration disturbance potency of epigallocatechin gallate (EGCG) synthetic analogs and EGCG PEGylated PLGA nanoparticles in rat neurospheres

Plant‐Inspired Pyrogallol‐Containing Functional Materials

A practical review on the measurement tools for cellular adhesion force

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