Green tea extract inhibits the onset of periodontal destruction in rat experimental periodontitis

Abstract

These findings demonstrate that green tea extract suppresses the onset of loss of attachment and alveolar bone resorption in a rat model of experimental periodontitis.

Effects of theaflavins on tissue inflammation and bone resorption on experimental periodontitis in rats

“…The number of CD45‐positive cells was calculated according to the method of Yoshinaga et al with some modifications. Four square fields (100 × 100 μm) of connective tissue adjacent to the junctional epithelium (JE) were selected from each section (Figure ).…”

“…To date, many studies have shown the potential treatment effects of catechins on periodontitis in vitro and in vivo . Recently, locally delivered green tea extract gel has been used as an adjunct to nonsurgical periodontal treatment .…”

“…27 To date, many studies have shown the potential treatment effects of catechins on periodontitis in vitro and in vivo. 28,29 Recently, locally delivered green tea extract gel has been used as an adjunct to nonsurgical periodontal treatment. 30 However, few studies have shown the potential effects of TFs in the control of periodontal disease, and these studies were limited to in vitro experiments.…”

Green tea prevents vascular disturbs and attenuates periodontal breakdown in long‐term hyperglycaemia in T1D rats

“…In T1D-GT, NcVEGF+/mm 2 , NcCD31+/mm 2 and MVD levels in the PDL maintained similar to those observed in NG rats and it was associated with major preservation of periodontal tissues when compared to T1D-W. Our results suggest a major vascular response and healing during bacterial challenge in the diabetic periodontal tissue that received green tea. In addition, in previous study, the green tea intake reduced expression of the pro-inflammatory cytokines TNFα and RANKL to normal levels in PDL of STZ-T1D rats reducing the osteoclastic bone resorption (Gennaro et al, 2015) which is also observed in periodontitis induced by ligature or Escherichia coli LPS in rats treated with EGCG polyphenol-green (Cho et al, 2013;Yoshinaga et al, 2014). Since, TNFα induces VEGF, reduction of TNFα in diabetic rats by green tea can lead for VEGF reduction to normal levels (Turer, Durmus, Balli, & Guven, 2017).…”

Topical application of glycyrrhetinic acid in the gingival sulcus inhibits attachment loss in lipopolysaccharide‐induced experimental periodontitis in rats

“…Immunohistological staining of complement component C1q was performed to detect immune complexes, as described previously . After the sections were deparaffinized, endogenous peroxidase activity was blocked with 0.3% H 2 O 2 /methanol for 30 minutes, followed by incubation in normal goat serum for 30 minutes at room temperature.…”