Green tea extract inhibits early oncogenic responses in mice with nonalcoholic steatohepatitis

Dey, Priyankar; Kim, Joshua B.; Chitchumroonchokchai, Chureeporn; Li, Jinhui; Sasaki, Geoffrey Y.; Olmstead, Bryan D.; Stock, Katie; Thomas‐Ahner, Jennifer M.; Clinton, Steven K.; Bruno, Richard S.

doi:10.1039/c9fo01199d

Cited by 17 publications

(12 citation statements)

References 62 publications

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“…Catechins are flavan‐3‐ols, the bioactive component of Camellia sinensis and Acacia catechu . Catechins are one of the well‐studied and promising phytochemicals responsible for diverse bioactivities related to the mitigation of inflammatory injury (Dey et al, 2018; Dey et al, 2020; Li et al, 2017). Of special interest, recent data suggest that epigallocatechin gallate (EGCG) which is the most predominant catechin, could be effective against different viral infections.…”

Section: Antiinflammatory Phytochemicals During Viral Infectionmentioning

confidence: 99%

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Antiinflammatory phytochemicals against virus‐induced hyperinflammatory responses: Scope, rationale, application, and limitations

Baranwal

Gupta

Dey

et al. 2021

Phytotherapy Research

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Uncontrolled inflammatory responses or cytokine storm associated with viral infections results in deleterious consequences such as vascular leakage, severe hemorrhage, shock, immune paralysis, multi‐organ failure, and even death. With the emerging new viral infections and lack of effective prophylactic vaccines, evidence‐based complementary strategies that limit viral infection‐mediated hyperinflammatory responses could be a promising approach to limit host tissue injury. The present review emphasizes the potentials of antiinflammatory phytochemicals in limiting hyperinflammatory injury caused by viral infections. The predominant phytochemicals along with their mechanism in limiting hyperimmune and pro‐inflammatory responses under viral infection have been reviewed comprehensively. How certain phytochemicals can be effective in limiting hyper‐inflammatory response indirectly by favorably modulating gut microbiota and maintaining a functional intestinal barrier has also been presented. Finally, we have discussed improved systemic bioavailability of phytochemicals, efficient delivery strategies, and safety measures for effective antiinflammatory phytotherapies, in addition to emphasizing the requirement of tightly controlled clinical studies to establish the antiinflammatory efficacy of the phytochemicals. Collectively, the review provides a scooping overview on the potentials of bioactive phytochemicals to mitigate pro‐inflammatory injury associated with viral infections.

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Section: Antiinflammatory Phytochemicals During Viral Infectionmentioning

confidence: 99%

“…Finally, we have catechins, another class of flavan‐3‐ols, rich in tea and Acacia catechu (Dey et al, 2018; Saha et al, 2016). Due to its presence in the highest quantity, EGCG is considered a key bioactive constituent of the catechin family.…”

Section: Phytochemical Bioavailability Dictates Bioactivity: Relevanc...mentioning

confidence: 99%

Antiinflammatory phytochemicals against virus‐induced hyperinflammatory responses: Scope, rationale, application, and limitations

Baranwal

Gupta

Dey

et al. 2021

Phytotherapy Research

Self Cite

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“…Due to the anti-inflammatory properties of some natural products, their role as new and complementary treatments is being tested. For example, green tea extract administered to mice with nonalcoholic steatohepatosis has shown to inhibit the early oncogenic response [124]. In line with this results, Ocoxin regulated the cytokine milieu during liver colonization, decreased the pro-inflammatory IL1β, interferon gamma (IFNγ) and TNFα cytokine expression while reduced the macrophage infiltration into the tumor stroma and [76][77][78].…”

Section: The Antitumor Effect In Preclinical In Vitro and In Vivo Modmentioning

confidence: 67%

Ocoxin as a complement to first line treatments in cancer

Benedicto¹,

Sanz²,

Márquez³

2021

Int. J. Med. Sci.

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“…TCE-exposed females expressed high levels of proliferation and cell cycle markers, ki67 and cyclnd1 , relative to control females and males, regardless of TCE exposure. Like IL-6 related markers and chemokines/cytokines, KI67 and Cyclin D1 dysregulation is an indicator of many different liver conditions including hepatocellular carcinoma ( Salama et al, 2019 ), nonalcoholic fatty liver disease ( Dey et al, 2019 ), chronic alcohol exposure ( Chavez et al, 2011 ), and liver injury ( Inomata et al, 2018 ). The role of these proteins are not well described in AIH, however; experimentally-induced AIH had altered levels of these proliferation markers ( Huang et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Sex-Dependent Effects on Liver Inflammation and Gut Microbial Dysbiosis After Continuous Developmental Exposure to Trichloroethylene in Autoimmune-Prone Mice

et al. 2020

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Trichloroethylene (TCE) is a common environmental toxicant linked with hypersensitivity and autoimmune responses in humans and animal models. While autoimmune diseases are more common in females, mechanisms behind this disparity are not clear. Recent evidence suggests that autoimmunity may be increasing in males, and occupational studies have shown that TCE-mediated hypersensitivity responses occur just as often in males. Previous experimental studies in autoimmune-prone MRL +/+ mice have focused on responses in females. However, it is important to include both males and females in order to better understand sex-disparity in autoimmune disease. In addition, because of an alarming increase in autoimmunity in adolescents, developmental and/or early life exposures to immune-enhancing environmental pollutants should also be considered. Using MRL +/+ mice, we hypothesized that TCE would alter markers related to autoimmunity to a greater degree in female mice relative to male mice, and that TCE would enhance these effects. Mice were continuously exposed to either TCE or vehicle beginning at gestation, continuing during lactation, and directly in the drinking water. Both male and female offspring were evaluated at 7 weeks of age. Sex-specific effects were evident. Female mice were more likely than males to show enhanced CD4 + T cell cytokine responses (e.g., IL-4 and IFN-γ). Although none of the animals developed pathological or serological signs of autoimmune hepatitis-like disease, TCE-exposed female mice were more likely than males in either group to express higher levels of biomarkers in the liver related to regeneration/repair and proliferation. Levels of bacterial populations in the intestinal ileum were also altered by TCE exposure and were more prominent in females as compared to males. Thus, our expectations were correct in that young adult female mice developmentally exposed to TCE were more likely to exhibit alterations in immunological and gut/liver endpoints compared to male mice.

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Green tea extract inhibits early oncogenic responses in mice with nonalcoholic steatohepatitis

Abstract: Nonalcoholic steatohepatitis (NASH) increases hepatocellular carcinoma (HCC) risk.

Cited by 17 publications

References 62 publications

Antiinflammatory phytochemicals against virus‐induced hyperinflammatory responses: Scope, rationale, application, and limitations

Antiinflammatory phytochemicals against virus‐induced hyperinflammatory responses: Scope, rationale, application, and limitations

Ocoxin as a complement to first line treatments in cancer

Sex-Dependent Effects on Liver Inflammation and Gut Microbial Dysbiosis After Continuous Developmental Exposure to Trichloroethylene in Autoimmune-Prone Mice

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