Green tea extract attenuates cyclosporine A-induced oxidative stress in rats

Mohamadin, Ahmed M.; El-Beshbishy, Hesham A.; El‐Mahdy, Mohamed A.

doi:10.1016/j.phrs.2004.04.007

Cited by 87 publications

(58 citation statements)

References 44 publications

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“…Reduction of renal SOD activity in CsA-treated rats was observed in our study, which was similar to the previous studies [29]. Reduced glutathione, together with GPx, is important in maintaining the structure of mitochondrial and cell membranes.…”

Section: Discussionsupporting

confidence: 92%

Therapeutic efficacy of naringin on cyclosporine (A) induced nephrotoxicity in rats: Involvement of hemeoxygenase-1

Chandramohan

Parameswari

2013

Pharmacological Reports

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Abstract:Background: Clinically, chronic nephrotoxicity may lead to renal functional impairment and progress to end stage renal failure. The renoprotective effect of a flavonoid naringin (NG) against cyclosporine A (CsA)-induced nephrotoxicity was investigated in this study. Methods: Nephrotoxicity was induced in male albino Wistar rats by injecting 25 mg/kg body weight of CsA for a period of 21 days. CsA-induced rats were also cotreated with 40 mg of NG/kg body weight, orally. Results: After the experimental period, the levels of lipid peroxides (TBARS) and hydroxyl radical (OH ) were found to be elevated, whereas the levels of SOD, catalase, glutathione, vitamin C, E and A were decreased in CsA-induced rats. NG co-treatment significantly decreased the levels of lipid peroxides and hydroxyl radicals and restored the levels of enzymic and non-enzymic antioxidants in renal tissues. Histological analysis revealed that CsA administration caused severe and widespread necrosis with dilatation of proximal tubules, vacuolization, tubular cell desquamation and intraluminal cast formation with massive infiltration of inflammatory cells. CsA-induced histopathological renal changes were minimal in animals which received NG treatment. The western blot and confocal microscopic expression of heme oxygenase-1 was restored by NG. In CsA-induced animals the expression was reduced compared to NG treated animals. Conclusions: The present study reveals that NG can act as effective renoprotective drug against CsA-induced toxicity.

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Section: Discussionsupporting

confidence: 92%

Therapeutic efficacy of naringin on cyclosporine (A) induced nephrotoxicity in rats: Involvement of hemeoxygenase-1

Chandramohan

Parameswari

2013

Pharmacological Reports

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“…GTE polyphenols also function indirectly as antioxidant through: (1) inhibition of pro-oxidants as inducible nitric oxide synthase, lipooxygenase, cyclooxygenase, and xanthine oxidase; (2) inhibition of redox-sensitive transcription factors, NF-kB, activator protein-1, and SOD. 43 Histopathological examination of renal tissue revealed the renoprotective effect of GTE and showed stromal cellular infiltration and decreased the numbers of necrotic cells; as reported by Mohamadin et al 10 In conclusion, GTE ameliorates GM-elicited nephrotoxicity and oxidative damage by improving antioxidant defense and tissue integrity. Further studies in both animals and humans are necessary to demonstrate the antioxidant properties and other effects of GTE on renal diseases.…”

supporting

confidence: 65%

“…9 Administration of green tea extract (GTE) prevents the generation of thiobarbituric acid reactive substances (TBARS) and significantly attenuates renal dysfunction induced by GM as assessed by the measures of serum creatinine, blood urea nitrogen (BUN), uric acid, and activity of antioxidant enzymes in the kidney homogenate. 10 However, until now, the ameliorative effect of GTE against GM-induced nephrotoxicity has not been fully investigated.…”

Section: Introductionmentioning

confidence: 99%

Amelioration of gentamicin nephrotoxicity by green tea extract in uninephrectomized rats as a model of progressive renal failure

Salem

Kamel

et al. 2010

Renal Failure

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Rationale: Gentamicin (GM) is an effective antibiotic against severe infection but has limitations related to nephrotoxicity. This study investigates whether green tea extract (GTE), an antioxidant, could ameliorate the nephrotoxic effect of GM in uninephrectomized rats. Objectives: The right kidneys of 40 rats were surgically removed and 1 week later the animals were divided into four groups (n = 10). Group 1 served as control, Group 2 as GTE group, Group 3 as GM group, and Group 4 as GM+GTE group. Kidney function, inflammatory cytokine TNF-a, oxidant and antioxidant parameters of renal tissue, as well as histopathological studies were assessed. Main findings: Injecting uninephrectomized rats with GM induced renal dysfunction as shown by significant elevations in serum creatinine and urea. Serum TNF-a and oxidative stress parameters (superoxide anion and lipid peroxides) were also significantly increased. On the contrary, antioxidative parameters [superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH)] were significantly decreased. Histopathological examination of renal tissue illustrated features of degeneration, marked cellular infiltration, tubular dilatation, and varying degrees of necrosis. GTE given to GM rats reduced these nephrotoxicity parameters. Serum creatinine, urea, and TNF-a were almost normalized in the GM+GTE group. The oxidative stress parameters were significantly decreased and the antioxidative parameters were significantly increased. Conclusion: GTE ameliorates GM-induced nephrotoxicity and oxidative damage by improving antioxidant defense and tissue integrity. Further human studies are necessary to demonstrate the antioxidant effects of GTE on renal diseases. Nevertheless, green tea (GT) may offer an inexpensive, nontoxic, and effective intervention strategy in subjects with a risk for GM-induced nephrotoxicity.

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“…Various antioxidants such as melatonin (Rezzani et al 2005), lycopene (Atessahin et al 2006), lipoic acid (Amudha et al 2006) and green tea (Mohamadin et al 2005) have been investigated for their potential effects to prevent the side effects of toxic substances. There is another type of antioxidants, flavonoids, which are richly found in fruits and vegetables.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of ellagic acid in d-galactosamine-induced kidney damage in rats

et al. 2015

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D-Galactosamine (D-GalN), which is an established experimental toxin, primarily causes liver injury by the generation of free radicals and depletion of UTP nucleotides. D-GalN intoxication also induces renal dysfunction thus, renal failure is often associated with the end-stage of the liver damage. We have investigated both preventive and curative effects of ellagic acid (EA) in this study. EA treatment at a gavage dose of 20 mg/kg body weight was administered before and after intraperitoneal (i.p.) injection of D-GalN at a dose of 750 mg/kg. Tissue and blood samples of animals were collected for morphological and biochemical evaluations. Our study results suggest that EA treatment both prior to and after the toxin administration successfully altered the toxic effects on the rats. Moreover, pre-treatment of EA was more protective than post-treatment indicated by histopathological and biochemical values. In conclusion, EA treatment both before and after D-GalN intoxication could protect kidney tissues against D-GalN induced oxidative stress.

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Green tea extract attenuates cyclosporine A-induced oxidative stress in rats

Cited by 87 publications

References 44 publications

Therapeutic efficacy of naringin on cyclosporine (A) induced nephrotoxicity in rats: Involvement of hemeoxygenase-1

Therapeutic efficacy of naringin on cyclosporine (A) induced nephrotoxicity in rats: Involvement of hemeoxygenase-1

Amelioration of gentamicin nephrotoxicity by green tea extract in uninephrectomized rats as a model of progressive renal failure

Protective effects of ellagic acid in d-galactosamine-induced kidney damage in rats

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