2010
DOI: 10.3109/0886022x.2010.517350
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Amelioration of gentamicin nephrotoxicity by green tea extract in uninephrectomized rats as a model of progressive renal failure

Abstract: Rationale: Gentamicin (GM) is an effective antibiotic against severe infection but has limitations related to nephrotoxicity. This study investigates whether green tea extract (GTE), an antioxidant, could ameliorate the nephrotoxic effect of GM in uninephrectomized rats. Objectives: The right kidneys of 40 rats were surgically removed and 1 week later the animals were divided into four groups (n = 10). Group 1 served as control, Group 2 as GTE group, Group 3 as GM group, and Group 4 as GM+GTE group. Kidney fun… Show more

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Cited by 22 publications
(16 citation statements)
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“…Nephrotoxicity is one of the most important side effects of the use of gentamicin resulted in reactive oxygen species generation such as superoxide anion, hydrogen peroxide and hydroxyl radicals in the kidney [4][5][6][7][8][9]. Gentamicin-induced nephrotoxicity increased the activity of superoxide dismutase [5,10,11], glutathione peroxidase [12] and catalase in animal models.…”
Section: Introductionmentioning
confidence: 99%
“…Nephrotoxicity is one of the most important side effects of the use of gentamicin resulted in reactive oxygen species generation such as superoxide anion, hydrogen peroxide and hydroxyl radicals in the kidney [4][5][6][7][8][9]. Gentamicin-induced nephrotoxicity increased the activity of superoxide dismutase [5,10,11], glutathione peroxidase [12] and catalase in animal models.…”
Section: Introductionmentioning
confidence: 99%
“…4 GM nephrotoxicity has a complex phenomenon characterized by an increase in plasma creatinine and urea levels as well as severe proximal renal tubular necrosis, followed by deterioration and renal failure. 1 It is apparent that the toxicity of GM involves renal free radical generation, reduction in antioxidant defense mechanism, acute tubular necrosis and glomerular congestion, 3 renal inflammatory cascades, high renal oxidative stress, and associating pathological signaling mechanisms. 5 Hypercholesterolemia (HC) plays an important role in the development and progression of atherosclerotic process, accelerates the development of fibrosis in the stenotic kidney, and increases the propensity for end stage of renal disease.…”
Section: Introductionmentioning
confidence: 99%
“…1,2 Aminoglycoside antibiotics, particularly gentamicin (GM), are frequently used in the treatment of severe gram-negative infection. 3 However, their clinical exploitation is limited due to the chance of nephrotoxicity.…”
Section: Introductionmentioning
confidence: 99%
“…The control group of rats (C group) received 1 ml saline solution per day intraperitoneally for 8 days. The green tea (GT) group received an oral administration of 300 mg/kg/day of green tea for 15 days using an intragastric enteral feeding protocol (1). The gentamicin (GM) group was injected subcutaneously with gentamicin (Actavis company, Leskovac, Serbia) 100 mg/kg/day for the last 8 days of experiment.…”
Section: Animalsmentioning
confidence: 99%
“…Gentamicin is a widely used aminoglycoside antibiotic with a low price and high effectivity in treatment of gram-negative and β-lactam resistent infections (1). However, its use has been limited because of its adverse effect of causing nephrotoxicity (2).…”
Section: Introductionmentioning
confidence: 99%