Green tea epigallocatechin-3-gallate inhibits microsomal prostaglandin E2 synthase-1

Green tea inhibits cycolooxygenase-2 in non-small cell lung cancer cells through the induction of Annexin-1

“…The addition of glucocorticoid to A549 cells results in ANX1 translocation to the membrane compartment and subsequent externalization which inhibited prostaglandin release by affecting cPLA 2 activation through an effect of EGF signaling, thereby blocking cell proliferation [5,19]. Green tea and its polyphenol constituents have been reported to inhibit PGE 2 production [20,21]. Koeberle et al reported that EGCG, a major constituent of green tea up to 30 µM suppressed PGE 2 production through inhibiting the transformation of PGH 2 to PGE 2 catalyzed by microsomal PGE 2 synthase-1 (mPGES-1, IC 50 =1.8 µM) [21].…”

“…Green tea and its polyphenol constituents have been reported to inhibit PGE 2 production [20,21]. Koeberle et al reported that EGCG, a major constituent of green tea up to 30 µM suppressed PGE 2 production through inhibiting the transformation of PGH 2 to PGE 2 catalyzed by microsomal PGE 2 synthase-1 (mPGES-1, IC 50 =1.8 µM) [21]. Moon et al reported that EGCG at the concentration of 25 µM inhibited COX-2 but increased PGE 2 production and mPGES-1 expression in A549 cells.…”

Perspective of microsomal prostaglandin E2 synthase-1 as drug target in inflammation-related disorders

“…mPGES-1 as target of these NPs may provide a basis for their antiinflammatory properties and rationalize their use in folk medicine as remedy for treatment of inflammatory disorders. Among these plant-derived mPGES-1 inhibitors are prominent antiinflammatory and anti-tumoral compounds like the polyphenol curcumin from turmeric [86], epigallocatechin-3-gallate (EGCG) from green tea [87], the acylphloroglucinol hyperforin from St. John´s wort [66] and garcinol from Garcinia indica [88], triterpene acids from frankincense (e.g., tirucallic acids, lupeolic acids, boswellic acids,) [89,90], the diterpenoids carnosol and carnosic acid from Salvia officinalis [91], and the quinone embelin from Embelia ribes [92]. All of them inhibit mPGES-1 in cell-free assays in the submicromolar range (Table 1).…”

Green tea polyphenols avert chronic inflammation-induced myocardial fibrosis of female rats

“…Similar inhibitory action of GTP on TNF-a has been reported by He et al [18], who state that green tea suppressed LPS-induced liver injury in a D-dalactosamine-sensitized rat model via a reduction in TNF-a-induced apoptosis of hepatocytes. In addition, cellular studies also demonstrated that (i) ECGC down-regulated LPS-induced activation of TLR4 signaling pathway in macrophages through the 67-kDa laminin receptor [19], and (ii) EGCG significantly inhibited cellular PGE 2 biosynthesis in LPS-stimulated human whole blood through a suppression of the microsomal prostaglandin E 2 synthase-1 mechanism [20].…”