Green tea polyphenols avert chronic inflammation-induced myocardial fibrosis of female rats

Shen, Chwan‐Li; Samathanam, Christina; Tatum, Owatha L.; Graham, Suzanne; Tubb, Christine; Cao, Jay; Dunn, Dale M.; Wang, Jiasheng

doi:10.1007/s00011-011-0320-y

Cited by 15 publications

(12 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent studies have shown that EGCG inhibits telomere attrition mediated cardiomyocyte apoptosis in cardiac hypertrophy (Sheng et al 2012). In addition, green tea polyphenols attenuate myocardial fibrosis through a suppression of chronic inflammation and innate immune responses (Shen et al 2011). Using freshly isolated single heart myocytes, green tea extract was found to protect cardiomyocytes from post-ischemia-reperfusion injury by preventing cytosolic Ca 2+ overload, myofibril disruption, and alterations in adherens and gap junction protein expression and distribution (Liou et al 2010).…”

Section: Introductionmentioning

confidence: 99%

(−)-Epigallocatechin-3-gallate (EGCG) attenuates functional deficits and morphological alterations by diminishing apoptotic gene overexpression in skeletal muscles after sciatic nerve crush injury

Renno

Al‐Maghrebi

Al-Banaw

2012

Naunyn-Schmiedeberg's Arch Pharmacol

View full text Add to dashboard Cite

Muscle degeneration and impairment following nerve injury could lead to apoptosis as a result of increased levels of reactive oxygen species. This activates the apoptotic cascade through mitochondrial dysfunction and damage to lipids, proteins, and DNA. In considering of the multifactorial protective properties of green tea polyphenols (-)-epigallocatechin-3-gallate (EGCG), this study investigates whether EGCG treatment does improve skeletal muscle function impairments, induced by crushing of the sciatic nerve. Compared to the saline-treated injured group of animals, EGCG treatment of axonotomized animals showed significant motor enhancement in the toe spread and foot positioning analysis and gain in the percentage motor deficit. The proprioceptive function expressed by the hopping response showed significant progression in the EGCG-treated group. Recovery of sensory innervation was followed by a slowly retreating neuropathic pain-like syndrome in the EGCG-treated animals. Muscle tissues from injured limb showed severe histopathological alterations that were significantly attenuated by EGCG treatment at the end of week 3 post-surgery. Semi-quantitative desmin immunohistochemistry revealed intense staining in the saline-treated injured animals, whereas EGCG treatment decreased the desmin immunoreactivity back to sham control levels. Using RT-PCR, EGCG treatment induced a significant anti-apoptotic effect in injured muscle tissues by normalizing the Bax/Bcl-2 ratio back to baseline levels and inhibiting overexpression of the p53 apoptotic gene at days 3 and 7 post-surgery. In conclusion, our results demonstrate that EGCG enhances functional recovery, protects muscle fibers from cellular death by activating anti-apoptotic signaling pathway, and improves morphological recovery in skeletal muscle after nerve injuries.

show abstract

Section: Introductionmentioning

confidence: 99%

(−)-Epigallocatechin-3-gallate (EGCG) attenuates functional deficits and morphological alterations by diminishing apoptotic gene overexpression in skeletal muscles after sciatic nerve crush injury

Renno

Al‐Maghrebi

Al-Banaw

2012

Naunyn-Schmiedeberg's Arch Pharmacol

View full text Add to dashboard Cite

show abstract

“…Epidemiological, clinical, and experimental studies have established a wide range of pharmacological effects of green tea catechins on cardiovascular diseases [9]. Catechins, mainly EGCG, exert vascular protective effects through multiple mechanisms, including antioxidative, anti-inflammatory, and anti-proliferative effects [9][10][11][12].…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Epigallocatechin-3 Gallate on Atrial Electrical and Structural Remodeling in a Rabbit Rapid Atrial Pacing Model

Zhu

Xiao

et al. 2014

Cell Biochem Biophys

View full text Add to dashboard Cite

Epigallocatechin-3 gallate (EGCG) is the major catechin in green tea. The aim of this study is to investigate the effects of EGCG on atrial electrical and structural remodeling in a rabbit rapid atrial pacing (RAP) model. New Zealand white rabbits were subjected to RAP with or without EGCG treatment. The atrial electrophysiology was studied. ELISA, Western blots, and RT-PCR were performed to determine the level of the inflammation markers, oxidative stress, and fibrogenic agents. Atrial tissue was stained with Masson's trichrome stain for fibrosis detection. RAP rabbits showed a significantly shorter atrial effective refractory period than control rabbits. Higher AF inducibility and longer AF duration were seen in the RAP group. AERP of rabbits received high dose EGCG were prolonged compared to RAP rabbits, and AF inducibility and duration of rabbits received high dose EGCG were lower. RAP rabbits have higher inflammation markers, higher oxidative stress, and more significant fibrosis within atrium, while high dose intervention of EGCG can lower the inflammation, oxidative stress, and fibrosis induced by RAP. Results showed that EGCG have protective effects on atrial electrical and structural remodeling in a rabbit RAP model in terms of attenuating of inflammation and oxidative stress.

show abstract

“…The in vivo part of this study showed that EGCG inhibited neutrophil recruitment, inflammation-driven angiogenesis, and pulmonary fibrosis. Yet another in vivo study completed by Shen et al [27] demonstrated that fibrosis in female rats caused by chronic inflammation was significantly reduced when treated with GT catechins. Regulatory T cells (T-reg) are essential in maintaining immune functions by targeting sites of sustained inflammation [28].…”

Section: Inflammationmentioning

confidence: 99%

Green Tea as an Agricultural Based Health Promoting Food: The Past Five to Ten Years

Shi

Schlegel

2012

Agriculture

View full text Add to dashboard Cite

Abstract:The consumption of tea originated in ancient China over 4000 years ago and is currently the second most popular beverage in the world after water. Tea is an aromatic beverage prepared by pouring hot water over cured leaves of the Camellia sinensis plant. The link between tea intake, most notably green tea, and health has resulted in intense research on the components responsible for preventing the onset of several chronic diseases, including atherosclerosis, cancer, obesity and diabetes. In particular, the high levels of chemically diverse phenols (e.g., phenolic acids, flavonoids) present in tea exhibit potent protective properties against many of these diseases. Although health related research on green tea and its predominant phenol (catechins) has been on-going for decades, major advances have occurred in the last 5-10 years. Therefore, this review focuses on seminal studies reported primarily within the last five years but not extending past ten years on the link between health and green tea with an emphasis on the catechins.

show abstract

Green tea polyphenols avert chronic inflammation-induced myocardial fibrosis of female rats

Abstract: GTP attenuates myocardial fibrosis through a suppression of chronic inflammation and innate immune responses.

Cited by 15 publications

References 30 publications

(−)-Epigallocatechin-3-gallate (EGCG) attenuates functional deficits and morphological alterations by diminishing apoptotic gene overexpression in skeletal muscles after sciatic nerve crush injury

(−)-Epigallocatechin-3-gallate (EGCG) attenuates functional deficits and morphological alterations by diminishing apoptotic gene overexpression in skeletal muscles after sciatic nerve crush injury

Protective Effects of Epigallocatechin-3 Gallate on Atrial Electrical and Structural Remodeling in a Rabbit Rapid Atrial Pacing Model

Green Tea as an Agricultural Based Health Promoting Food: The Past Five to Ten Years

Contact Info

Product

Resources

About