Green tea and hepatoxicity: Two case reports

Percevault, Soizic; Charpiat, B.; Lebossé, Fanny; Mabrut, Jean‐Yves; Vial, Thierry; Colom, Matthieu

doi:10.1016/j.therap.2021.10.004

Cited by 3 publications

(2 citation statements)

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“…However, the re-exposure test results, which were reassessed using an established and strict criterion, showed a negative causality for these two herbs ( Teschke et al, 2015 ). Cha -associated hepatotoxicity was also once reported ( Percevault et al, 2021 ), but on the other hand, evidence was found to support the hepatoprotective effects of its active compounds, L-theanine ( Wang et al, 2020b ; Wang et al, 2020c ; Zhang et al, 2021 ; Chen et al, 2022a ; Hamad Shareef et al, 2022 ; Wu et al, 2022 ). Moreover, chuan xiong and sheng jiang were reported to exhibit hepatoprotective effects ( Lu et al, 2015 ; Amin et al, 2021 ; Yaghubi Beklar et al, 2021 ; Bekkouch et al, 2022 ; Guo et al, 2022 ).…”

Section: Discussionmentioning

confidence: 72%

Natural products for migraine: Data-mining analyses of Chinese Medicine classical literature

et al. 2022

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Background: Treatment effect of current pharmacotherapies for migraine is unsatisfying. Discovering new anti-migraine natural products and nutraceuticals from large collections of Chinese medicine classical literature may assist to address this gap.Methods: We conducted a comprehensive search in the Encyclopedia of Traditional Chinese Medicine (version 5.0) to obtain migraine-related citations, then screened and scored these citations to identify clinical management of migraine using oral herbal medicine in history. Information of formulae, herbs and symptoms were further extracted. After standardisation, these data were analysed using frequency analysis and the Apriori algorithm. Anti-migraine effects and mechanisms of actions of the main herbs and formula were summarised.Results: Among 614 eligible citations, the most frequently used formula was chuan xiong cha tiao san (CXCTS), and the most frequently used herb was chuan xiong. Dietary medicinal herbs including gan cao, bai zhi, bo he, tian ma and sheng jiang were identified. Strong associations were constructed among the herb ingredients of CXCTS formula. Symptoms of chronic duration and unilateral headache were closely related with herbs of chuan xiong, gan cao, fang feng, qiang huo and cha. Symptoms of vomiting and nausea were specifically related to herbs of sheng jiang and ban xia.Conclusion: The herb ingredients of CXCTS which presented anti-migraine effects with reliable evidence of anti-migraine actions can be selected as potential drug discovery candidates, while dietary medicinal herbs including sheng jiang, bo he, cha, bai zhi, tian ma, and gan cao can be further explored as nutraceuticals for migraine.

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Section: Discussionmentioning

confidence: 72%

Natural products for migraine: Data-mining analyses of Chinese Medicine classical literature

et al. 2022

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“…Liver damage usually occurred when the products were taken for weight loss, although some cases in which the supplement was used to counteract hair loss and for improving well-being have been reported too [ 24 , 25 ]. Accordingly, two recent hepatotoxicity cases associated with green tea consumption have been reported too [ 78 ]. The suspected products often were characterized by a different catechin composition and sometimes EGCG high-concentrated extracts were used; in many cases, green tea preparations were taken in combination with other components, including botanicals, pure phytochemicals, vitamins, amino acids, and others.…”

Section: Resultsmentioning

confidence: 99%

Efficacy and Safety of Oral Green Tea Preparations in Skin Ailments: A Systematic Review of Clinical Studies

et al. 2022

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Green-tea-based products and their polyphenols, especially epigallocatechin-3-gallate, have attracted great attention over the years as possible nutraceuticals, due to their promising bioactivities, especially antioxidant and anti-inflammatory, which could be exploited in several diseases, including skin ailments. In this context, the present study aimed at reviewing clinical evidence about the benefits of the oral administration of green tea preparations and its polyphenols to relieve skin disorders, to point out the current knowledge, and to suggest possible novel strategies to effectively exploit the properties of green tea, also managing safety risks. To this end, a systematic review of the existing literature was carried out, using the PRISMA method. Few studies, including five focused on UV-induced erythema and skin alterations, three on photoaging, two on antioxidant skin defenses, and one on acne and genodermatosis, were retrieved. Despite several benefits, clinical evidence only supports the use of oral green tea preparations to protect skin from damage induced by ultraviolet radiation; in other cases, conflicting results and methodological limits of clinical trials do not allow one to clarify their efficacy. Therefore, their application as adjuvant or alternative sunscreen-protective interventions could be encouraged, in compliance with the safety recommendations.

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Multiple drugs

2022

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Green tea and hepatoxicity: Two case reports

Cited by 3 publications

References 7 publications

Natural products for migraine: Data-mining analyses of Chinese Medicine classical literature

Natural products for migraine: Data-mining analyses of Chinese Medicine classical literature

Efficacy and Safety of Oral Green Tea Preparations in Skin Ailments: A Systematic Review of Clinical Studies

Multiple drugs

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