Green Synthesis of Therapeutic Nanoparticles: an Expanding Horizon

Abstract

Nanotechnology continues to achieve tremendous awards in therapeutics, but the economical and ecofriendly production of nanoparticles (NPs) is still in infancy, simply due to the nanotoxicity, unprecedented health hazards and scale up issues. Green nanotechnology was introduced in the quest to mitigate such risks by utilizing natural resources as biological tool for NP synthesis. The key advantages offered by green approach include lower capital and operating expenses, reduced environmental impacts, superior biocompatibility and higher stability. In this review, we shed light on the biosynthesis of therapeutic NPs along with their numerous biomedical applications. Toxicity aspects of NPs and the impact of green approach on it, is also discussed briefly.

Biogenic Synthesis of Silver Nanoparticles Using Guava (<i>Psidium guajava</i>) Leaf Extract and Its Larvicidal Action against <i>Anopheles gambiae</i>

“…Moreover, movements in the global distribution and burden of infectious diseases with climate change are observed [16]. By generating NPs obtained from plant metabolites with therapeutic potential, the scientific community is aiming to overcome these chal- [18]. In the present study, we report for the first time the larvicidal action of green Ag NPs synthesized from P. guajava L. leaf extract against 4 th instar larvae of A. gambiae (s.l.).…”

Recent Developments in Nanotechnology for Detection and Control of Aedes aegypti-Borne Diseases

“…In contrast, standard physical and chemical techniques typically involve high energy consumption, due to the need for high pressures and temperatures (Benelli et al, 2018b). In addition, potentially harmful reagents and solvent are not used in green synthesis methods, because the reducing and stabilizing agents are substituted by molecules produced by living organisms (Kumar et al, 2015). These agents can be extracted from bacteria, fungi, yeasts, algae, or plants (Sintubin et al, 2012).…”

Biocompatible green synthesized silver nanoparticles impact on insecticides resistant developing enzymes of dengue transmitted mosquito vector

“…At present, nanotechnology have been widely used in all fields, especially, the silver nanoparticles are used in various field research, including pharmaceutical industries to develop a best anti-microbial drugs, agriculture, bio labeling, parasitology and pest management [7,8]. Silver naoparticles have been synthesized using different types of reducing agent, of which, the plantmediated biosynthesis of silver nanoparticles is advantageous over chemical and physical methods, since it is a cheap, single-stepped and did not require high energy, temperature, pressure [9,10]. A number of plants-synthesized nanoparticles have been reported as effective adulticides, pupicides, larvicides, ovicides and ovideterrents effects against various mosquito species [2].…”