Green Synthesis of Stable Copper Nanoparticles and Synergistic Activity with Antibiotics

Mandava, Kiranmai; Kadimcharla, Keerthi; Keesara, Neeraja R; Fatima, Sumayya N; Bommena, Prathyusha; Batchu, Uma R

doi:10.4172/pharmaceutical-sciences.1000281

Cited by 33 publications

(23 citation statements)

References 16 publications

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“…Microbial diversity and community composition significantly affect agricultural soil productivity, plant growth, and crop quality (Nayyar et al, 2009, Wu et al, 2011). Variation in the diversity and composition of the microbial community is believed to be related to changes in many factors (Derinkuyu et al, 2017, Mandava et al, 2017, Salameh et al, 2018, Scoppa et al, 2017). Such as cropping systems and root exduates (Bell et al, 2013, Yang et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Effects of phenolic acids from ginseng rhizosphere on soil fungi structure, richness and diversity in consecutive monoculturing of ginseng

Zhou

et al. 2018

Saudi Journal of Biological Sciences

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Ginseng yield and quality are seriously compromised by consecutive monoculturing in northeastern China. The imbalance of soil fungi communities and autotoxicity of ginseng are the major factors in consecutive monoculturing ginseng crops. Soil fungal communities were identified using Illumina MiSeq sequencing, applied to soils that consecutively cultured ginseng (CCG) for six years and new forest soil (NFS), or receiving application of phenolic acids (PAs). The CCG field received five treatments with five different phenolic acids, including gallic acid (GA), salicylic acid (SA), 3-phenylpropionic acid (3-PA), benzoic acid (BA) and cinnamic acid (CA), which were detected from ginseng rhizosphere in consecutive cropping soil. Fungal richness, fungi diversity, community composition, relative taxon abundances, root rot disease, and growth rate were compared among the different treatments. 579 fungal operational taxonomic units at 97% ITS sequence identity were found among 201,617 sequence reads derived from 18 separate soil samples. Members of the phylum Ascomycota dominated the soil fungal communities, and putative pathogens, such as Fusarium, Gibberella and Nectriaceae_unclassified which may include the abundant sexual morph of Cylindrocarpon destructans, showed higher relative abundances in the CCG fields. Compared to the CCG and NFS fields, PAs (except CA) enhanced the fungi richness and decreased fungi diversity. Cluster analysis indicated that the PAs (except CA) changed the fungi structure in a uniform way. PAs stimulate root rot disease and enhance disease severity, restricting plant growth. The results suggest that the PAs (except CA) may enhance the fungi richness, decrease the fungi diversity and changed the fungi structure to increase fungal pathogen loads, which could explain the declined yield and quality of ginseng in consecutively monocultured ginseng crops.

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Section: Discussionmentioning

confidence: 99%

Effects of phenolic acids from ginseng rhizosphere on soil fungi structure, richness and diversity in consecutive monoculturing of ginseng

Zhou

et al. 2018

Saudi Journal of Biological Sciences

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“…10 Though synthesis of CuO nanomaterial is cost-effective as compared to silver (Ag), gold (Au) and platinum (Pt) nanoparticles, but to attain its stability is still a challenging task. 11,12 Many studies have been performed on the synthesis of CuO nanomaterial which include vapor deposition 13 to electrochemical reduction, 14 radiolysis reduction, 15 thermal decomposition 16 and chemical reduction. 17 But these strategies are associated with the contamination issues and harm ecosystems as well as human health.…”

Section: Introductionmentioning

confidence: 99%

“…5 Thus, to overcome these shortfalls, the principle of green chemistry utilizing natural origin sources such as plants and microbes for the synthesis process may prove to be a potential solution. 12 In the present study, an attempt has been made to develop an eco-friendly, cost-effective technique for the synthesis of CuO nanorods (CuO NRs) by reducing Cu 2+ ions in the copper sulfate solution using Momordica charantia (Bitter gourd) fruit extract. The characterization of CuO NRs was done by standard physiochemical techniques.…”

Section: Introductionmentioning

confidence: 99%

<p>Green Synthesis, Characterization and Antimicrobial Activity of Copper Oxide Nanomaterial Derived from <em>Momordica charantia</em></p>

Qamar¹,

Rehman²,

Chauhan³

et al. 2020

IJN

106

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Background: In the emerging field of nanotechnology, copper oxide (CuO) nanomaterials are considered to be one of the most important transition metal oxides owing to its fascinating properties. Its synthesis from green chemistry principles is gaining importance as next-generation antibiotics due to its simplicity, eco-friendliness, and cost-effectiveness. In the present study, CuO nanorods (CuO NRs) were synthesized from the aqueous fruit extract of Momordica charantia and characterized using different analytical techniques. Further, the biomedical therapeutic potential was evaluated against multi-drug resistant microbial strains. Materials and Methods: To synthesize CuO NRs, 0.1M of CuSO 4 .5H 2 O solution was added to aqueous extract of Momordica charantia in a 1:3 (v/v) ratio (pH=11) and heated at 50°C followed by washing and drying. The synthesized CuO NRs were subjected to characterization using different analytical techniques such as UV visible spectroscopy, zeta sizer equipped with zeta potential, Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM) equipped with energydispersive X-ray spectroscopy (EDS) and transmission electron microscopy (TEM). Further, the application as a biomedical therapeutic potential was evaluated in vitro using well diffusion method against eleven multidrug-resistant clinical bacterial strains, a fungus-Trichophyton rubrum and in ovo against the R 2 B virus using haemagglutination (HA) test. Results: Characterization was preliminarily done by the spectral study that confirms the absorbance band at 245nm. FTIR analysis at 628 cm −1 peak identified copper oxide vibration. SEM analysis revealed agglomerated particle clusters. However, with TEM clear nanorods of average diameter of 61.48 ± 2 nm were observed. EDAX confirmed CuO formation while XRD showed a typical monoclinic structure with 6 nm crystallite size. Biological screening of CuO NRs showed significant results against both in vitro and in ovo methods. Significant inhibitory activity (p<0.0001) was noted against most of the resistant human pathogenic strains including both Gram-positive and Gram-negative bacteria. The highest efficacy was observed against Bacillus cereus with a 31.66 mm zone of inhibition. Besides, the therapeutic potential of CuO NRs against Corynebacterium xerosis, Streptococcus viridians and R 2 B strain of Newcastle disease is reported for the first time.Conclusion: Based on the present results, it could be expected that green synthesized CuO NRs would find potential applications in the field of nanomedicine.

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“…The synthesis of CuNPs, which uses copper acetate as the common precursor, is seen as more cost-effective than AgNPs, AuNPs, and PtNPs [14,15].…”

Section: Other Mnpsmentioning

confidence: 99%

Biogenic Metal Nanoparticles: A New Approach to Detect Life on Mars?

Simões

Ottoni

Antunes

2020

Life

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Metal nanoparticles (MNPs) have been extensively studied. They can be produced via different methods (physical, chemical, or biogenic), but biogenic synthesis has become more relevant, mainly for being referred by many as eco-friendly and more advantageous than others. Biogenic MNPs have been largely used in a wide variety of applications, from industry, to agriculture, to health sectors, among others. Even though they are increasingly researched and used, there is still space for exploring further applications and increasing their functionality and our understanding of their synthesis process. Here, we provide an overview of MNPs and biogenic MNPs, and we analyze the potential application of their formation process to astrobiology and the detection of life on Mars and other worlds. According to current knowledge, we suggest that they can be used as potential biosignatures in extra-terrestrial samples. We present the advantages and disadvantages of this approach, suggest further research, and propose its potential use for the search for life in future space exploration.

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Green Synthesis of Stable Copper Nanoparticles and Synergistic Activity with Antibiotics

Cited by 33 publications

References 16 publications

Effects of phenolic acids from ginseng rhizosphere on soil fungi structure, richness and diversity in consecutive monoculturing of ginseng

Effects of phenolic acids from ginseng rhizosphere on soil fungi structure, richness and diversity in consecutive monoculturing of ginseng

<p>Green Synthesis, Characterization and Antimicrobial Activity of Copper Oxide Nanomaterial Derived from <em>Momordica charantia</em></p>

Biogenic Metal Nanoparticles: A New Approach to Detect Life on Mars?

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