Green synthesis of silver nanoparticles using<i>Tropaeolum majus</i>: Phytochemical screening and antibacterial studies

Bawazeer, Sami; Rauf, Abdur; Shah, Syed Muhammad Hassan; Shawky, Ahmed M.; Al-Awthan, Yahya S.; Bahattab, Omar; Uddin, Ghias; Sabir, Javeria; El‐Esawi, Mohamed A.

doi:10.1515/gps-2021-0003

Cited by 61 publications

(24 citation statements)

References 29 publications

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“…The plant contains bioactive compounds which have a strong capacity to reduce heavy metals [66,68]. Many plants, including Salix alba, Allium cepa, Crocus sativus, and Tropaeolum majus, have been documented to synthesize metal nanoparticles [25,64,[69][70][71]. In the present investigation, it is proved that the extracts of the title plant contain various classes of compounds that possess the capacity to reduce gold ion and produce stable nanoparticles.…”

Section: Discussionmentioning

confidence: 67%

Green Synthesis of Gold Nanoparticles Using Extract of Pistacia chinensis and Their In Vitro and In Vivo Biological Activities

Alhumaydhi

2022

Journal of Nanomaterials

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The synthesis of metal nanoparticles by using plant extracts is previously explored in phytomedicines. Nanobiotechnology has many applications, including cosmetic, packing, coating, biomedicine, and enhanced biological activity. Keeping in view the importance of Pistacia chinensis, its gold nanoparticles (AuNPs) have been synthesized by the eco-friendless and cost-effective method. In this study, the synthesized nanoparticles were characterized by advanced techniques such as UV-visible spectroscopy, Fourier transform infrared (FT-IR), and atomic force microscope (AFM) analysis. The biological activities of these synthesized nanoparticles were examined in vitro by measuring the enzymatic inhibition potential on urease and carbonic anhydrase and in vivo by determining the analgesic and sedative activities. The UV spectrum indicated various peaks at the range of 530-550 nm, showing nanoparticles formation. The FT-IR spectroscopy of the extracts and AuNPs indicated the presence of NH, C═N, and N═O in the extract involved in the nanoparticles synthesis. The size of nanoparticles was determined by AFM analysis. The AFM showed that the nanoparticles range from 10 to 100 nm and are almost spherical in shape. The synthesized AuNPs exhibited significant urease inhibition potential with an IC50 value of 44.98. Similarly, the nanoparticles exhibited good carbonic anhydrase inhibition with an IC50 value of 53.54 against acetazolamide having IC50 0.13. Pistacia chinensis extract and its AuNPs exhibited excellent attenuation p < 0.01 in acetic acid-induced writhing model at a dose of 15 mg/kg. The synthesized nanoparticles showed a significant sedative effect p < 0.001 compared to the standard drug. This research work has developed a green method to synthesize nanoparticles by using Pistacia chinensis extract and directed the researcher to purify active phytochemicals from Pistacia chinensis involved in nanoparticles synthesized.

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Section: Discussionmentioning

confidence: 67%

Green Synthesis of Gold Nanoparticles Using Extract of Pistacia chinensis and Their In Vitro and In Vivo Biological Activities

Alhumaydhi

2022

Journal of Nanomaterials

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“…The antibacterial results also revealed that silver nanoparticles had higher activity than the plant extract due to their larger surface area, which allows for greater interaction with the bacteria’s cell surfaces. These findings were compared to prior research that found silver nanoparticles to have potent antibacterial properties ( Pal et al, 2007 ; Al-Otibi et al, 2020 ; Bawazeer et al, 2021 ). In the present study, we reported the antibacterial activity of TpAgNPs against methicillin-resistant S. aureus clinical isolate and P. aeruginosa for the first time.…”

Section: Resultsmentioning

confidence: 84%

Antioxidant, Cytotoxic, and Antimicrobial Potential of Silver Nanoparticles Synthesized using Tradescantia pallida Extract

Shahzadi

Shah

et al. 2022

Front. Bioeng. Biotechnol.

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Silver nanoparticles have received much attention, due to their wide range of biological applications as an alternative therapy for disease conditions utilizing the nanobiotechnology domain for synthesis. The current study was performed to examine the antioxidant, anticancer, antibacterial, and antifungal potential of biosynthesized silver nanoparticles (TpAgNPs) using plant extract. The TpAgNPs were produced by reacting the Tradescantia pallida extract and AgNO3 solution in nine various concentration ratios subjected to bioactivities profiling. According to the current findings, plant extract comprising phenolics, flavonoids, and especially anthocyanins played a critical role in the production of TpAgNPs. UV–visible spectroscopy also validated the TpAgNP formation in the peak range of 401–441 nm. Further, the silver ion stabilization by phytochemicals, face-centered cubic structure, crystal size, and spherical morphology of TpAgNPs were analyzed by FTIR, XRD, and SEM. Among all TpAgNPs, the biosynthesized TpAgNP6 with a medium concentration ratio (5:10) and the plant extract had effective antioxidant potentials of 77.2 ± 1.0% and 45.1 ± 0.5% free radical scavenging activity, respectively. The cytotoxic activity of TpAgNP6 in comparison to plant extract for the rhabdomyosarcoma cell line was significantly the lowest with IC50 values of 81.5 ± 1.9 and 90.59 ± 1.6 μg/ml and cell viability % of 24.3 ± 1.62 and 27.4 ± 1.05, respectively. The antibacterial and antifungal results of TpAgNPs revealed significant improvement in comparison to plant extract, i.e., minimum inhibition concentration (MIC) 64 μg/ml against Gram-negative Pseudomonas aeruginosa while, in the case of antifungal assay, TpAgNP6 was active against Candida parapsilosis. These TpAgNPs play a crucial role in determining the therapeutic potential of T. pallida due to their biological efficacy.

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“…The fortified Petri dishes were incubated for 24 h, at 37 °C. After 24 h, the vernier caliper was used to measure the zone of inhibition [ 25 ].…”

Section: Methodsmentioning

confidence: 99%

Characterization and Evaluation of Antimicrobial Potential of Trigonella incise (Linn) Mediated Biosynthesized Silver Nanoparticles

et al. 2022

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The goal of the research was to explore a new green method used to synthesize silver nanoparticles (Ag NPs) from an aqueous extract of Trigonella incise, which serves as a reducing and stabilizing agent. The obtained results showed an 85% yield of nanoparticles by using 2:5 (v/v) of 5% plant extract with a 0.5 M solution of AgNO3. Different techniques were used to characterize the synthesized Ag NPs, including X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and UV–visible spectroscopy. The UV–visible spectra of green synthesized silver nanoparticles showed maximum absorption at a wavelength of 440 nm. The FT-IR studies revealed the stretching oscillation frequency of synthesized silver nanoparticles in the absorption band near 860 cm−1. Similarly, the bending and stretching oscillation frequencies of the NH function group were assigned to the band in the 3226 cm−1 and 1647 cm−1 regions. The bending vibration of C-O at 1159 cm−1 confirmed the carbonyl functional group that was also assigned to the small intensity band in the range of 2361 cm−1. The X-ray diffraction analysis of Ag NPs revealed four distinct diffraction peaks at 2θ of 38°, 45°, 65° and 78°, corresponds to (111), (200), (220) and (311) of the face-centered cubic shape. The round shape morphology of Ag NPs with a mean diameter in the range 20–80 nm was analyzed via SEM images. Furthermore, the nanoparticles showed more significant antimicrobial activity against Salmonella typhi (S. typhi) and Staphylococcus aureus (S. aureus) with an inhibition zone of 21.5 mm and 20.5 mm at 6 μg/mL concentrations, respectively, once compared to the standard reference. At concentrations of 2 µg/mL and 4 µg/mL, all of the bacterial strains showed moderate activity, with inhibition zones ranging from 11 mm to 18.5 mm. Even at high concentrations of AgNPs, S. typhi showed maximum resistance. The best antifungal activity was observed by synthesized Ag NPs against Candida albicans (C. albicans) with 21 mm zone of inhibition, as compared to a standard drug which gives 22 mm of inhibition. Therefore, we conclude that the antibacterial and antifungal activities showed satisfactory results from the synthesized Ag NPs.

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Green synthesis of silver nanoparticles usingTropaeolum majus: Phytochemical screening and antibacterial studies

Cited by 61 publications

References 29 publications

Green Synthesis of Gold Nanoparticles Using Extract of Pistacia chinensis and Their In Vitro and In Vivo Biological Activities

Green Synthesis of Gold Nanoparticles Using Extract of Pistacia chinensis and Their In Vitro and In Vivo Biological Activities

Antioxidant, Cytotoxic, and Antimicrobial Potential of Silver Nanoparticles Synthesized using Tradescantia pallida Extract

Characterization and Evaluation of Antimicrobial Potential of Trigonella incise (Linn) Mediated Biosynthesized Silver Nanoparticles

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