Green synthesis of silver nanoparticles using Momordica cymbalaria aqueous leaf extracts and screening of their antimicrobial activity

Gopu, Chaitanya; Chirumamilla, Pavani; Kagithoju, Srikanth; Taduri, Shasthree

doi:10.1007/s40011-022-01367-x

Cited by 7 publications

(2 citation statements)

References 26 publications

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“…Some properties of nanoparticles such as concentration, shape, and size have a significant effect on their toxic effect ( Swamy et al, 2015 ). NPs contact cells by electrostatic interaction and cause an increase in the amount of ROS DNA, RNA, and some vital enzymes that have a high affinity for these species ( Gopu et al, 2022 ). In addition, AgNPs cause cell death by activating structures responsible for cell apoptosis ( Selvan et al, 2018 ).…”

Section: Resultsmentioning

confidence: 99%

Green synthesis of silver nanoparticles mediated Diospyros kaki L. (Persimmon): determination of chemical composition and evaluation of their antimicrobials and anticancer activities

Keskin,

Ölçekçi,

Baran

et al. 2023

Front. Chem.

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The eco-friendly synthesis of metallic nanoparticles (MNPs) using biological materials is an encouraging and innovativeness approach to nanotechnology. Among other synthesizing methods, biological methods are chosen because of their high efficiency and purity in many aspects. In this work, using the aqueous extract obtained from the green leaves of the D. kaki L. (DK); silver nanoparticles were synthesized in a short time and simply with an eco-friendly approach. The properties of the synthesized silver nanoparticles (AgNPs) were characterized using various techniques and measurements. In the characterization data of AgNPs, Maximum absorbance at 453.34 nm wavelengths, the average size distribution of 27.12 nm, the surface charge of −22.4 mV, and spherical appearance were observed. LC-ESI-MS/MS analysis was used to assess the compound composition of D. kaki leaf extract. The chemical profiling of the crude extract of D. kaki leaves revealed the presence of a variety of phytochemicals, predominantly phenolics, resulting in the identification of five major high-feature compounds: two major phenolic acids (Chlorogenic acid and Cynarin), and tree flavonol glucosides (hyperoside, quercetin-3-glucoside, and quercetin-3- D-xyloside). The components with the highest concentrations were cynarin, chlorogenic acid, quercetin-3- D-xyloside, hyperoside, and quercetin-3-glucoside, respectively. Antimicrobial results were determined by a MIC assay. The biosynthesized AgNPs exhibited strong antibacterial activity against the human and food pathogen Gram (+ and −) bacteria and good antifungal activity against pathogenic yeast. It was determined that 0.03–0.050 μg/mL concentrations ranges of DK-AgNPs were growth suppressive concentrations on all pathogen microorganisms. The MTT technique was used to study the cytotoxic effects of produced AgNPs on cancer cell lines (Glioblastoma (U118), Human Colorectal Adenocarcinoma (Caco-2), Human Ovarian Sarcoma (Skov-3) cancer cell lines, and Human Dermal Fibroblast (HDF) healthy cell line). It has been observed that they have a suppressive effect on the proliferation of cancerous cell lines. After 48 h of treatment with Ag-NPs, the DK-AgNPs were found to be extremely cytotoxic to the CaCo-2 cell line, inhibiting cell viability by up to 59.49% at a concentration of 50 g mL−1. It was found that the viability was inversely related to the DK-AgNP concentration. The biosynthesized AgNPs had dose-dependent anticancer efficacy. Because of the high concentration of bioactive chemicals in Diospyros kaki, it may be employed as a biological resource in medicinal applications. DK-AgNPs were shown to be an effective antibacterial agent as well as a prospective anticancer agent. The results provide a potential approach for the biogenic production of DK-AgNPs utilizing D. kaki aqueous leaf extract.

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Section: Resultsmentioning

confidence: 99%

Green synthesis of silver nanoparticles mediated Diospyros kaki L. (Persimmon): determination of chemical composition and evaluation of their antimicrobials and anticancer activities

Keskin,

Ölçekçi,

Baran

et al. 2023

Front. Chem.

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“…cymbalaria has been used in various Asian herbal medicine systems for an extended duration [23]. Momordica plants are known for their biologically active compounds [24]. The identified alkaloids, flavonoids, and saponins are particularly noteworthy, as these compounds have been associated with a range of beneficial biological activities.…”

Section: Introductionmentioning

confidence: 99%

Phyto-Mediated Green Synthesis of Silver Nanoparticles Using an Aqueous Leaf Extract of Momordica cymbalaria: Antioxidant, Cytotoxic, Antibacterial, and Photocatalytic Properties

Sundar,

Rajagopal,

Nivetha

et al. 2024

Separations

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In this study, we biosynthesized the stable silver nanoparticles (AgNPs) from Momordica cymbalaria leaves to evaluate their antioxidant, antibacterial, cytotoxic, and photocatalytic properties. Initially, we screened the bioactive compounds from M. cymbalaria extract using GC-MS. The biosynthesis of Mc-AgNPs was confirmed using instruments, such as UV-visible spectroscopy FT-IR, XRD, SEM with EDX, and HR-TEM analyses. The UV-visible spectrum indicated absorbance at 425 nm. The crystallite size of the M. cymbalaria-stabilized nanoparticles was determined to be 20.14 nm. The morphology and size of the synthesized Mc-AgNPs were confirmed via SEM-EDX and HR-TEM analyses, with a size range from 16 to 22 nm. The synthesized Mc-AgNPs exhibited a photocatalytic yield of 60%. The biosynthesized Mc-AgNPs demonstrated strong antioxidant properties and prominent antibacterial activity against human pathogenic bacteria. The cytotoxicity study revealed that Mc-AgNPs were effective against MCF-7 cells in a dose-dependent manner. The recognized bioactivities confirm that the synthesized Mc-AgNPs act as effective catalysts in oxidation and serve as potent antioxidant, anticancer, and antibacterial agents.

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Synthesis of green nanoparticles for energy, biomedical, environmental, agricultural, and food applications: A review

Osman,

Zhang,

Farghali

et al. 2024

Environ Chem Lett

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Nanomaterials have been rapidly developed during the last decades, yet many nanoparticles synthesized by classical methods are toxic and their synthesis procedure is not sustainable. Here we review the green synthesis of nanoparticles from biomass and waste with a focus on synthetic mechanisms and applications in energy production and storage, medicine, environmental remediation, and agriculture and food. Biomass use for synthesis include microorganisms, fungi, plants, and agro-industrial bio-waste. Compared to conventional synthesis, green synthesis allows a 30% reduction in energy consumption, cost savings of up to 40%, and a 50% increase in production output. Biomedical applications comprise antibacterials, anticancers, antioxidants, and drug delivery mechanisms. Carbon quantum dots and photovoltaics are discussed in the energy section. Agricultural and food applications focus on nanofertilization, pest control, and food quality. Environmental remediation includes water and soil purification.

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Green synthesis of silver nanoparticles using Momordica cymbalaria aqueous leaf extracts and screening of their antimicrobial activity

Cited by 7 publications

References 26 publications

Green synthesis of silver nanoparticles mediated Diospyros kaki L. (Persimmon): determination of chemical composition and evaluation of their antimicrobials and anticancer activities

Green synthesis of silver nanoparticles mediated Diospyros kaki L. (Persimmon): determination of chemical composition and evaluation of their antimicrobials and anticancer activities

Phyto-Mediated Green Synthesis of Silver Nanoparticles Using an Aqueous Leaf Extract of Momordica cymbalaria: Antioxidant, Cytotoxic, Antibacterial, and Photocatalytic Properties

Synthesis of green nanoparticles for energy, biomedical, environmental, agricultural, and food applications: A review

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