Green Synthesis of Gold Nanoparticles Using Aqueous Extracts of Ziziphus jujuba and Gum arabic

Jafarizad, Abbas; Safaee, Khadijeh; Ekinci, Duygu

doi:10.1007/s10876-017-1258-1

Cited by 10 publications

(2 citation statements)

References 37 publications

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“…Their excellent stabilization ability ensures uniform and stable nanoparticle formation, while their eco-friendly nature reduces environmental impact and promotes sustainable nanomaterial synthesis. Examples of green reducing agents include plant extracts, phytochemicals, microorganisms, and polysaccharides, such as Arabic Gum [14][15][16][17][18][19][20]. This gum is the complex exudate of the Acacia senegal and Acacia seyal trees, and it has great relevance in the pharmaceutical and food industries [21].…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of Mesquite-Gum-Stabilized Gold Nanoparticles for Biomedical Applications: Physicochemical Properties and Biocompatibility Assessment

Pinilla-Torres,

Sanchez-Dominguez,

Basilio-Bernabe

et al. 2023

Polymers

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Using cytotoxic reducing and stabilizing agents in the synthesis of gold nanoparticles (AuNPs) limits their use in biomedical applications. One strategy to overcome this problem is using “green” synthesis methodologies using polysaccharides. In the present study, we propose a green methodology for synthetizing AuNPs with mesquite gum (MG) as a reducing agent and steric stabilizer in Gold(III) chloride trihydrate aqueous solutions to obtain biocompatible nanoparticles that can be used for biomedical applications. Through this method, AuNPs can be produced without using elevated temperatures or pressures. For synthetizing gold nanoparticles coated with mesquite gum (AuNPs@MG), Gold(III) chloride trihydrate was used as a precursor, and mesquite gum was used as a stabilizing and reducing agent. The AuNPs obtained were characterized using UV-Vis spectroscopy, dynamic light scattering, transmission electron microscopy, scanning transmission electron microscopy, and FT-IR spectroscopy. The stability in biological media (phosphate buffer solution), cytotoxicity (MTT assay, hematoxylin, and eosin staining), and hemocompatibility (Hemolysis assay) were measured at different concentrations and exposure times. The results showed the successful synthesis of AuNPs@MG with sizes ranging from 3 to 30 nm and a zeta potential of −31 mV. The AuNPs@MG showed good colloidal stability in PBS (pH 7.4) for up to 24 h. Finally, cytotoxicity assays showed no changes in cell metabolism or cell morphology. These results suggest that these gold nanoparticles have potential biomedical applications because of their low cytotoxicity and hemotoxicity and improved stability at a physiological pH.

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Section: Introductionmentioning

confidence: 99%

Green Synthesis of Mesquite-Gum-Stabilized Gold Nanoparticles for Biomedical Applications: Physicochemical Properties and Biocompatibility Assessment

Pinilla-Torres,

Sanchez-Dominguez,

Basilio-Bernabe

et al. 2023

Polymers

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“…The fruit of jujube tree is used as antioxidant, anthelmintic, hepatoprotective, antiinflammatory, antibacterial, and also anti-inflammation agent [19][20][21][22]. There are few reports for biosynthesis of nanoparticles using jujube fruit extract [23][24][25][26][27]. In this study, we introduced an easy and safe route for the biosynthesis of green AuNPs and therapeutic potential of the AuNPs in diabetes.…”

Section: Introductionmentioning

confidence: 99%

Anti-dyslipidemic properties of green gold nanoparticle: improvement in oxidative antioxidative balance and associated atherogenicity and insulin resistance

et al. 2020

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Background Nowadays, the green synthesis of AuNPs in the presence of plants has been attracted a lot of attention. Herein, in vivo antidiabetic activity of AuNPs synthesized using Ziziphus jujuba in streptozotocin-induced diabetic rats has been evaluated. Methods Formation of AuNPs was confirmed by UV-vis, HR-TEM and XRD. Different doses of jujube gold nanoparticles (0.5 and 1 mg/kg) were used to treat streptozotocin-induced diabetic rats in different groups. At the end of experiment (21 days), serum level of fasting blood glucose (FBG), insulin, Body weight, HOMA-IR, vitamin D, ALT, AST, urea, creatinine, lipid profile, prooxidant-antioxidant balance (PAB) and liver oxidative stress markers were determined. Results results showed a significant decrease in the level of liver MDA (P = 0.001), fasting blood glucose (P = 0.0001), HOMA-IR (P = 0.0001), ALT (P = 0.0001), AST (P = 0.0001), urea (P = 0.02), Triglycerides (P = 0.002), Total cholesterol (P = 0.0001), PAB (P = 0.0001) and AIP (P = 0.001) and in contrast a significant increase total antioxidant capacity (P = 0.02), insulin (P = 0.03), Body weight (P = 0.0001) and vitamin D (P = 0.0001) in the AuNPs-treated diabetic group compared to the diabetic rats. No significant change was observed in the total thiol group (P = 0.18), LDL-C (P = 0.43), creatinine (P = 0.09) and HDL-C (P = 0.71) level in diabetic rats treated with AuNPs compared to diabetic rats. Conclusion The results of this study proves that green AuNPs exerted promising antidiabetic and anti-oxidant properties.

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Rapid Room-Temperature Synthesis of Gold Nanoparticles Using Sargentgloryvine Stem Extract and Their Photocatalytic Activity

Sun

et al. 2018

J Inorg Organomet Polym

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Green Synthesis of Gold Nanoparticles Using Aqueous Extracts of Ziziphus jujuba and Gum arabic

Cited by 10 publications

References 37 publications

Green Synthesis of Mesquite-Gum-Stabilized Gold Nanoparticles for Biomedical Applications: Physicochemical Properties and Biocompatibility Assessment

Green Synthesis of Mesquite-Gum-Stabilized Gold Nanoparticles for Biomedical Applications: Physicochemical Properties and Biocompatibility Assessment

Anti-dyslipidemic properties of green gold nanoparticle: improvement in oxidative antioxidative balance and associated atherogenicity and insulin resistance

Rapid Room-Temperature Synthesis of Gold Nanoparticles Using Sargentgloryvine Stem Extract and Their Photocatalytic Activity

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