Green synthesis of gold nanoparticles and their enhanced synergistic antitumor activity using HepG2 and MCF7 cells and its antibacterial effects

Muthukumar, Thangavelu; Sudhakumari,; Sambandam, Balaji; Aravinthan, Adithan; Sastry, T. P.; Kim, Jong-Hoon

doi:10.1016/j.procbio.2015.12.017

Cited by 118 publications

(56 citation statements)

References 44 publications

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“…The most antibacterial effect of these NPs was against B. subtilis with MIC values of 62.5 μg/mL whereas MIC values of biosynthesized NPs against other strains were 250 μg/mL (Table ). In a similar study, by synthesized AuNPs from Carica papaya , MIC values for E. coli, B. subtilis , and S. aureus were 62.5, 250, and 125 μg/mL, respectively that was in contrast to our study. In our work, MIC for B. subtilis and E. coli were calculated as 62.5 and 250 μg/mL while no effect was observed on S. aureus and P. aeruginosa .…”

Section: Discussionmentioning

confidence: 99%

“…This different activity on different bacteria may be related to physicochemical properties of nanoparticles and difference in plant metabolites absorbed by nanoparticles' cornea that play significant roles in tolerance or susceptibility of bacteria . These differences in antibacterial activities can also be linked to differences in bacterial cell wall composition . Kim et al .…”

Section: Discussionmentioning

confidence: 99%

“…57 These differences in antibacterial activities can also be linked to differences in bacterial cell wall composition. 56 Kim et al 58 showed that the AuNPs make bind with active sites of the bacterial cell membrane and hence, inhibit the cell cycle function. Further studies revealed that the possible mechanisms of AuNPs interaction with the external surface of the bacterial membrane include its deposit in the cell wall, penetrate through porin channels in the membrane and interrupt the membrane integrity.…”

Section: Discussionmentioning

confidence: 99%

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Biological applications of phytosynthesized gold nanoparticles using leaf extract of Dracocephalum kotschyi

Chahardoli

Karimi

Fattahi

et al. 2018

J Biomedical Materials Res

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In this work, biosynthesis potentials of Dracocephalum kotschyi leaf extract for the production of gold nanoparticle (AuNPs) were studied, and the biological (catalytic, antibacterial, antioxidant, and anticancer) activities of studied AuNPs were evaluated. Different analytical techniques including UV–visible spectroscopy, X‐ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), energy dispersive X‐ray analysis, and transmission electron microscopy (TEM) were used for the characterization of AuNPs. Moreover, Different testing methods were used for evaluating biological activities of biosynthesized AuNPs. The formation of AuNPs was confirmed by color change and UV–visible spectroscopic analysis. Field emission (FE)‐SEM and TEM images were used to characterize phytosynthesized AuNPs which were predominantly spherical in shape with size in the range of 5–21 nm. These spherical NPs were found to be 39.79 ± 5 nm in size as determined by dynamic light scattering particle size analyzer. XRD pattern confirms the crystalline nature of the biosynthesized nanoparticles. The phytoconstituents involved in the reduction and stabilization of nanoparticles have been identified using FTIR spectra. The phytosynthesized AuNPs showed effective antioxidant, antibacterial and catalytic reduction activities. Furthermore, they have inhibited H1229 and MCF‐7 cancer cell lines proliferation in a dose‐dependent manner. These results have supported that D. kotschyi leaf extract was very efficient for the synthesis of AuNPs, and synthesized NPs showed enhanced biological activities which make them suitable for biomedical applications. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 621–630, 2019.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Biological applications of phytosynthesized gold nanoparticles using leaf extract of Dracocephalum kotschyi

Chahardoli

Karimi

Fattahi

et al. 2018

J Biomedical Materials Res

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“…Synthesized gold nanoparticles from leaf extract of different species have been examined with their antibacterial/ antimicrobial activity. The leaf extracts of plant species namely Coleus ambainicus [88], Salix alba [89], Zizyphus mauritiana [90], Solanum nigrum [91], Trianthema decandra [92] and Catharanthus roseus [93] have been examined to carry out biogenic synthesis process for gold nanoparticles by many researchers. Gold nanoparticles extracted from the leaf extracts of Mentha piperita [94], Salicornia brachiata [95], Cucurbita pepo and Malva crispa [96] have also been screened for antibacterial activity.…”

Section: Energy Dispersive Spectroscopy (Eds)mentioning

confidence: 99%

Biogenic Synthesis of Gold Nanoparticles and their Applications: A Review

Kaur¹,

Sharma²

2019

Asian J. Chem.

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The purpose of the present study is to explore the merits and demerits of various biogenic synthesis route of gold nanoparticles using plant materials and microbes. Literature survey indicated that microbe mediated synthesis route is found to be quite effective buttheavailability and feasibility of microbes, enzyme control conditions is of great challenge for the researchers. Among all the available bio-reductants for the synthesis of gold nanoparticles rhizome of Zinger officinale (ginger) has been found more advantageous in accordance with availability, stability, applicability, reaction time, etc. for the fabrication of gold nanoparticles.

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“…Now that there is an escalating demand to develop new antimicrobial approaches against pathogenic microorganisms that are gradually becoming more resistant to various types of antibiotics, metal nanoparticles such as AuNPs are started to be accepted as being a new class of antibiotics. Most of the green synthesized AuNPs were reported to induce efficient antimicrobial activities comparable to the AuNPs synthesized by chemical and other synthetic methods (Li et al, ; Muthukumar et al, ). Especially, to cope with multidrug‐resistant bacteria, one of the most influential strategies to enhance antibacterial efficacy could be the conjugation of antibiotics with AuNPs.…”

Section: Introductionmentioning

confidence: 99%

One‐pot facile synthesis of silk sericin‐capped gold nanoparticles by UVC radiation: Investigation of stability, biocompatibility, and antibacterial activity

Aktürk

Gök

Erdemli

et al. 2019

J Biomedical Materials Res

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Herein, an easy one‐pot synthesis method for gold nanoparticles (AuNPs), involving only gold salt and sericin extracted from silkworm cocoon in the presence of ultraviolet C (UVC) radiation, was developed. Nanoparticle formation was confirmed by characteristic surface plasmon resonance peaks at 520–540 nm wavelengths, and the influence of silk sericin on enhancing the colloidal stability of AuNPs was confirmed. Transmission electron microscopy examination showed the average size (<10 nm) and size distribution decreased significantly with higher sericin concentration. No antibacterial activity was observed on Gram‐positive Bacillus subtilis or Gram‐negative Escherichia coli for sole AuNPs (0.065–0.26 mg/ml), but the conjugation of AuNPs with streptomycin antibiotic decreased significantly the required minimum inhibitory concentration doses, as also confirmed with agar plating, Scanning Electron Microscopy and Atomic Force Microscopy analyses. Furthermore, sericin‐capped AuNPs showed high cell viabilities (>100%) and no sign of any detectable apoptosis or necrosis in 1‐day incubation. Also, high real‐time cell proliferation results of AuNPs competitive with positive control groups implied excellent in vitro biocompatibility. These results evidenced that sericin enhanced the colloidal stability of AuNPs and the biological activities of sericin‐capped AuNPs reported here could render them suitable nanoscale vehicles for biomedical applications.

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Green synthesis of gold nanoparticles and their enhanced synergistic antitumor activity using HepG2 and MCF7 cells and its antibacterial effects

Cited by 118 publications

References 44 publications

Biological applications of phytosynthesized gold nanoparticles using leaf extract of Dracocephalum kotschyi

Biological applications of phytosynthesized gold nanoparticles using leaf extract of Dracocephalum kotschyi

Biogenic Synthesis of Gold Nanoparticles and their Applications: A Review

One‐pot facile synthesis of silk sericin‐capped gold nanoparticles by UVC radiation: Investigation of stability, biocompatibility, and antibacterial activity

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