Green synthesis of gold nanoparticles in Gum Arabic using pulsed laser ablation for CT imaging

Abstract

Laser ablation synthesis in liquid solution (PLAL) is a green technique that allows for the physical formation of nanomaterials. This study indicates the preparation of stable gold nanoparticles (AuNPs) in Gum Arabic (GA) solution via laser ablation as a CT contrast agent. The optical properties were achieved using the absorption spectroscopic technique whereas the morphology and size distribution were investigated by TEM and ImageJ software. TEM image shows greater stability and spherical shape of GA-AuNPs with smaller size at 1.85 ± 0.99 nm compared to AuNPs without GA. The absorption spectrum of pure AuNPs has a lower absorption peak height in the visible range at λ = 521 nm, while the spectrum of GA-AuNPs has a higher plasmon peak height at λ = 514 nm with a blue shift towards lower wavelengths. The concentration of GA that dissolved in 10 mL of DI water via laser ablation is set at 20 mg. Increasing the number of pulses has only a minor effect on particle size distribution, which remains tiny in the nanometer range (less than 3 nm). For energies greater than 200 mJ, there is a blue shift toward shorter wavelengths. As the concentration of GA-AuNPs increases, the CT number is also increased indicating good image contrast. It can be concluded that there is a positive and significant influence of GA as a reducing agent for AuNPs, and a contrast agent for CT imaging which highlights its superiority in future medical applications.

A novel method for ZnO@NiO core–shell nanoparticle synthesis using pulse laser ablation in liquid and plasma jet techniques

“…When the absorption edges of ZnO nanoparticles get bigger, the optical band gap energy and the amount of light they can pass through go down 21 . In addition, the extrapolation of the hυ versus (αhυ) 2 curve was used to determine the energy band gap for the prepared sample. The optical energy bandgap of the manufactured samples might be ascertained using some techniques, such as the Tauc relation.…”

“…When the NiO NPs are used as shells for ZnO NPs, the optical band gap energy falls from 3.19 eV (pure ZnO) to 2.966 eV. After adding the NiO (shell), the band gap shrank, indicating that the Ni 2 + ions function as defect sites in the valence band to reduce the band gap. The quantum confinement effect can explain the decrease in bandgap energy and the increase in particle size.…”

“…Particles with a diameter of under 100 nm are known as nanoparticles. Metal nanoparticles (NPs) have significant benefits in a variety of fields, including medicine, biosensing, biomedical sciences, cosmetics, food, and electronics 2 , 3 .…”

“…2 curve was used to determine the energy band gap for the prepared sample. The optical energy bandgap of the manufactured samples might be ascertained using some techniques, such as the Tauc relation.…”

Recent Metal Nanotheranostics for Cancer Diagnosis and Therapy: A Review

“…In a study, the results showed that AuNPs could produce sensitization and synergistic effects in radiotherapy using different types of radiation [22][23][24][25]. In a major advance in 2022, Mzwd et al [26] used a green technique for nanoparticle synthesis. They formed and used stable AuNPs in gum arabic (GA) solution via laser ablation technique as a CT contrast agent.…”