Green Synthesis of Full-Color Fluorescent Carbon Nanoparticles from Eucalyptus Twigs for Sensing the Synthetic Food Colorant and Bioimaging

Damera, Deepthi Priyanka; Manimaran, Raghuraman; Venuganti, Venkata Vamsi Krishna; Nag, Amit

doi:10.1021/acsomega.0c03148

Cited by 21 publications

(7 citation statements)

References 71 publications

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“…NCs with cores of heavy metal compounds, such as CdSe, CdTe, and PbS, were initially the most widespread due to their easy synthesis and unique optical properties [ 125 , 126 ]. However, the current trend is to use the nontoxic cadmium-free and lead-free fluorescent NCs made of silicon [ 127 ], carbon [ 128 ], graphene [ 129 ], ZnS [ 130 ], CuInS 2 [ 131 ], AgInS 2 [ 132 ], or InP [ 133 ].…”

Section: Fluorescent Labels For Multiplexed 3d Imagingmentioning

confidence: 99%

Nontoxic Fluorescent Nanoprobes for Multiplexed Detection and 3D Imaging of Tumor Markers in Breast Cancer

et al. 2023

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Multiplexed fluorescent immunohistochemical analysis of breast cancer (BC) markers and high-resolution 3D immunofluorescence imaging of the tumor and its microenvironment not only facilitate making the disease prognosis and selecting effective anticancer therapy (including photodynamic therapy), but also provides information on signaling and metabolic mechanisms of carcinogenesis and helps in the search for new therapeutic targets and drugs. The characteristics of imaging nanoprobe efficiency, such as sensitivity, target affinity, depth of tissue penetration, and photostability, are determined by the properties of their components, fluorophores and capture molecules, and by the method of their conjugation. Regarding individual nanoprobe components, fluorescent nanocrystals (NCs) are widely used for optical imaging in vitro and in vivo, and single-domain antibodies (sdAbs) are well established as highly specific capture molecules in diagnostic and therapeutic applications. Moreover, the technologies of obtaining functionally active sdAb–NC conjugates with the highest possible avidity, with all sdAb molecules bound to the NC in a strictly oriented manner, provide 3D-imaging nanoprobes with strong comparative advantages. This review is aimed at highlighting the importance of an integrated approach to BC diagnosis, including the detection of biomarkers of the tumor and its microenvironment, as well as the need for their quantitative profiling and imaging of their mutual location, using advanced approaches to 3D detection in thick tissue sections. The existing approaches to 3D imaging of tumors and their microenvironment using fluorescent NCs are described, and the main comparative advantages and disadvantages of nontoxic fluorescent sdAb–NC conjugates as nanoprobes for multiplexed detection and 3D imaging of BC markers are discussed.

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Section: Fluorescent Labels For Multiplexed 3d Imagingmentioning

confidence: 99%

Nontoxic Fluorescent Nanoprobes for Multiplexed Detection and 3D Imaging of Tumor Markers in Breast Cancer

et al. 2023

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“…Nag and co-workers reported the preparation of light-blue CNPs for the detection of Brilliant Blue FCF (BB), a toxic synthetic food colorant. 81 These nanoparticles were obtained from dry Eucalyptus twigs and ammonium chloride as starting materials. Different emissive nanoparticles were obtained after filtration and washing.…”

Section: Cnps For Chemical Sensingmentioning

confidence: 99%

Fluorescence sensing by carbon nanoparticles

et al. 2022

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“…The fluorescence of the carbon NMs was quenched by Fe 3+ ions, which were then recovered by ATP, resulting in the establishment of an on and off detection system. Eucalyptus twig‐based full‐colored fluorescent carbon NMs have been prepared through the biogenic hydrothermal method (Damera et al, 2020). The NMs were successfully used to detect a synthetic food colorant (Brilliant Blue FCF), which if consumed in large quantities causes hazardous effects.…”

Section: Plant‐based Synthesis Of Green Nmsmentioning

confidence: 99%

Plant extract‐based synthesis of metallic nanomaterials, their applications, and safety concerns

Ullah

Lim

2022

Biotech & Bioengineering

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Nanotechnology has attracted the attention of researchers from different scientific fields because of the escalated properties of nanomaterials (NMs) compared with the properties of macromolecules. NMs can be prepared through different approaches involving physical and chemical methods. The development of NMs through plantbased green chemistry approaches is more advantageous than other methods from the perspectives of environmental safety, animal, and human health. The biomolecules and metabolites of plants act as reducing and capping agents for the synthesis of metallic green NMs. Plant-based synthesis is a preferred approach as it is not only cost-effective, easy, safe, clean, and eco-friendly but also provides pure NMs in high yield. Since NMs have antimicrobial and antioxidant potential, green NMs synthesized from plants can be used for a variety of biomedical and environmental remediation applications. Past studies have focused mainly on the overall biogenic synthesis of individual or combinations of metallic NMs and their oxides from different biological sources, including microorganisms and biomolecules.Moreover, from the viewpoint of biomedical applications, the literature is mainly focusing on synthetic NMs. Herein, we discuss the extraction of green molecules and recent developments in the synthesis of different plant-based metallic NMs, including silver, gold, platinum, palladium, copper, zinc, iron, and carbon. Apart from the biomedical applications of metallic NMs, including antimicrobial, anticancer, diagnostic, drug delivery, tissue engineering, and regenerative medicine applications, their environmental remediation potential is also discussed. Furthermore, safety concerns and safety regulations pertaining to green NMs are also discussed.

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Green Synthesis of Full-Color Fluorescent Carbon Nanoparticles from Eucalyptus Twigs for Sensing the Synthetic Food Colorant and Bioimaging

Cited by 21 publications

References 71 publications

Nontoxic Fluorescent Nanoprobes for Multiplexed Detection and 3D Imaging of Tumor Markers in Breast Cancer

Nontoxic Fluorescent Nanoprobes for Multiplexed Detection and 3D Imaging of Tumor Markers in Breast Cancer

Fluorescence sensing by carbon nanoparticles

Plant extract‐based synthesis of metallic nanomaterials, their applications, and safety concerns

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