Green Synthesis of Carbon Nanotubes-Reinforced Molecularly Imprinted Polymer Composites for Drug Delivery of Fenbufen

Liu, Xinlu; Yao, Hongfei; Chai, Mei-Hong; He, Wei; Huang, Yanping; Liu, Zhao‐Sheng

doi:10.1208/s12249-018-1192-z

Cited by 36 publications

(12 citation statements)

References 38 publications

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“…One of the most recent applications of DES is its use for the production of MIPs, either as medium or solvent [50,51], as MIPs modifier [51,52,53,54,55,56,57,58,59,60,61,62,63], as MIPs functional monomer [48,53,54,64,65,66,67,68,69,70,71,72], and even as MIPs template [67,69] (Table 2). From the whole publications involving DES and polymers, more than 15% correspond to DES and MIPs, reported just in the last four years [18].…”

Section: Polymeric Synthesis Using Desmentioning

confidence: 99%

Polymer Science and Engineering Using Deep Eutectic Solvents

et al. 2019

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The green and versatile character of deep eutectic solvents (DES) has turned them into significant tools in the development of green and sustainable technologies. For this purpose, their use in polymeric applications has been growing and expanding to new areas of development. The present review aims to summarize the progress in the field of DES applied to polymer science and engineering. It comprises fundamentals studies involving DES and polymers, recent applications of DES in polymer synthesis, extraction and modification, and the early developments on the formulation of DES–polymer products. The combination of DES and polymers is highly promising in the development of new and ‘greener’ materials. Still, there is plenty of room for future research in this field.

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Section: Polymeric Synthesis Using Desmentioning

confidence: 99%

Polymer Science and Engineering Using Deep Eutectic Solvents

et al. 2019

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“…A mixture of imidazolium tetrafluoroborate IL and choline chloride/ethylene glycol DES was used to facilitate the facile synthesis of doped single walled carbon nanotubes by dissolving and evenly distributing the starting materials. [ 130 ] A water/imidazolium tetrafluoroborate solution was used to synthesize bovine serum albumin NPs with well controlled size, as seen in Figure 5 . [ 131 ] This occurs because the albumin undergoes conformational changes at the IL/water interface, spontaneously forming particles of different sizes depending on the length of the side chain on the cation.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

“…IL charge and amphiphilicity characteristics have aided in the synthesis of a variety of polymer and protein nanoparticles, making potential drug carriers easier and safer to produce than the conventional methods. [ 115 , 116 , 117 , 118 , 119 , 120 , 121 , 125 , 128 , 130 , 131 , 132 , 133 ] In all, incorporating ILs into the synthesis or modification of nanocarriers is a promising emerging application for this solvent class. Careful selection of the IL components can impact the success of the synthesis procedure and the biocompatibility of the final material, and because the ILs retain their properties once placed onto the surfaces of nanoparticles, the tunability of ILs can be exploited to control the relationships between nanoparticles and their environments.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Recent Advances in Ionic Liquids in Biomedicine

2021

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The use of ionic liquids and deep eutectic solvents in biomedical applications has grown dramatically in recent years due to their unique properties and their inherent tunability. This review will introduce ionic liquids and deep eutectics and discuss their biomedical applications, namely solubilization of drugs, creation of active pharmaceutical ingredients, delivery of pharmaceuticals through biological barriers, stabilization of proteins and other nucleic acids, antibacterial agents, and development of new biosensors. Current challenges and future outlooks are discussed, including biocompatibility, the potential impact of the presence of impurities, and the importance of understanding the microscopic interactions in ionic liquids in order to design task-specific solvents.

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“…Table 1 shows the burst release from the samples. 68 JunYoung Park et al investigated the structure of methotrexate (MTX) surrounding carbon nanotubes through covalent and non-covalent (PEGylation) methods. In particular, covalent MTX bonds surrounding carbon nanotubes caused more structural distortion than non-covalent bonds (PEGylated CNT).…”

Section: Effective Utilization and Outcomes Of Carbon Nanotubes In Dr...mentioning

confidence: 99%

Carbon Nanotubes: An Optimistic Nanomaterial with Superfluity Characteristics in Drug Delivery for the Treatment of Arthritis

Srinivasan¹,

Palanisamy²

2022

Ind. J. Pharm. Edu. Res

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Arthritis is chronic disease that affects the joint system and induces pain and inflammation in human body. Nanotechnology based drug delivery has progressed to be viable and more attractive for the treatment of arthritis. A carbon nanotube is one of the foremost prominent nanomaterials with high surface area utilized to exhibit stable release of drugs. Nonetheless, researchers have done investigations using either single-walled carbon nanotubes (SWCNT) or multi-walled carbon nanotubes (MWCNT) to gain optimistic results in targeted delivery for arthritis disorder. In this view, functionalized carbon nanotubes are employed to deliver drugs with higher accuracy and controlled release of drugs with less toxic effects. Unfortunately, very limited investigations are reported the prospective utilization of functionalized carbon nanotubes as eminent drug carriers for arthritis treatment. Moreover, the amounts of toxicity of carbon nanotubes, as well as their aggregation in cells and tissues are the key limits that must be considered evidently. The biosafety exposure of carbon nanotubes to humans are still a source of concern. As a result, more research is needed to solve the obstacles associated with carbon nanotubes in conjugation with drugs such as agglomeration, lack of solubility and interaction mechanism with drugs. In this review, we discussed the significant characteristics and outcomes of carbon nanotubes in drug delivery for the treatment of arthritis disease. The toxic level of carbon nanotubes is projected and why the incorporation of CNTs in drug delivery is still limited in various phases is highlighted. The biosafety aspects, cellular uptake mechanism and the importance of functionalization carbon nanotubes in drug delivery are reviewed.

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Green Synthesis of Carbon Nanotubes-Reinforced Molecularly Imprinted Polymer Composites for Drug Delivery of Fenbufen

Cited by 36 publications

References 38 publications

Polymer Science and Engineering Using Deep Eutectic Solvents

Polymer Science and Engineering Using Deep Eutectic Solvents

Recent Advances in Ionic Liquids in Biomedicine

Carbon Nanotubes: An Optimistic Nanomaterial with Superfluity Characteristics in Drug Delivery for the Treatment of Arthritis

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