“…In contrast, breaking down macroscopic materials (such as food products and plants) to produce CNDs, is the principle of top-down approach [3,13]. Many different materials have been used to develop CNDs, including apple seeds [14], Citrus sinensis or Citrus limon peels [15], human fingernails [16,17], cotton [18], citrulline [19], coriander leaves [20], carrot juice [21], citric acid and tris(hydroxymethyl) methylaminomethane [22], polyethyleneimine, nitric acid [23], and many others. Additionally, many different procedures can be employed to produce CNDs, with the most commonly employed method being the solvothermal carbonization, pyrolysis, and microwave treatment [7,[24][25][26][27].…”