Green Synthesis of a Novel Silver Nanoparticle Conjugated with Thelypteris glandulosolanosa (Raqui-Raqui): Preliminary Characterization and Anticancer Activity

Vera-Nuñez, Lucero Del Carmen; Cornejo-Ruiz, Junior Oliver; Arenas-Chávez, Carlos Alberto; Hollanda, Luciana Maria de; Álvarez-Risco, Aldo; Del-Aguila-Arcentales, Shyla; Davies, Neal M.; Yáñez, Jaime A.; Vera-Gonzales, Corina

doi:10.3390/pr10071308

Cited by 12 publications

(14 citation statements)

References 154 publications

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“…Also, the PDI index is maintained around the value 0.34, except for the ratios 1:1, 1:2, and 1:15, at which it has values in the range 0.22–0.25. These results are comparable with those reported in literature for the synthesis of AgNPs using Acorous calamus rhizome extract–31.8 nm [ 57 ], turnip leaves extract ( Brassica rapa L. )–39.5 nm [ 58 ], leaves of Thelypteris glandulosolanosa –48.1 nm (PDI–0.472) [ 59 ], Melia azedarach –78 nm [ 60 ], Rubus rosifolius fruit extract–85.6 nm (PDI–0.266) [ 61 ], garlic clove extract–90 nm [ 62 ], fresh leaves of Mentha piperita –88 nm (PDI–0.132), and Amaranthus retroflexus –92 nm (PDI–0.232) [ 20 ].…”

Section: Resultssupporting

confidence: 90%

Design of Green Silver Nanoparticles Based on Primula Officinalis Extract for Textile Preservation

et al. 2022

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The present study aims to bring an addition to biomass resources valorization for environmental-friendly synthesis of nanoparticles. Thus, the green synthesis of silver nanoparticles (AgNPs) was performed, using a novel and effective reducing agent, Primula officinalis extract. The synthesis was optimized by monitoring the characteristic absorption bands, using UV–Vis spectroscopy, and by evaluating the size and physical stability. The phenolic consumption was established using Folin-Ciocâlteu method (1.40 ± 0.42 mg, representing ~5% from the total amount of poly--phenols) and the antioxidant activity was evaluated using chemiluminescence and TEAC methods. The optimum ratio extract to Ag ions was 1:3, for which the AgNPs presented a zeta potential value of −29.3 ± 1.2 mV and particles size of 5-30 nm. For characterization, EDS and XRD techniques were used, along with microscopy techniques (TEM). The AgNPs dispersions were applied on natural textile samples (cotton and wool), as a novel antimicrobial treatment for textile preservation. The treated fabrics were further characterized in terms of chromatic parameters and antimicrobial effect against Escherichia coli, Staphylococcus aureus, Bacillus subtilis, and Penicillium hirsutum strains. The high percentages of bacterial reduction, >99%, revealed that the AgNPs produced are a good candidate for textiles preservation against microbial degradation.

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Section: Resultssupporting

confidence: 90%

Design of Green Silver Nanoparticles Based on Primula Officinalis Extract for Textile Preservation

et al. 2022

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“…Its inefficient use of resources and lack of sustainable policy has resulted in a negative environmental impact [1,2]. Consequently, there is a growing trend in the consumption of sustainable, eco-friendly, and green clothing [2][3][4][5][6][7]. Indeed, consumers are becoming more aware of the current deterioration of the environment and are looking, for instance, for solutions to preserve the ecosystem and protect society [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Sustainable Fashion and Consumption Patterns in Peru: An Environmental-Attitude-Intention-Behavior Analysis

et al. 2022

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This study aims to outline the influence of Environmental Attitude (EA) in Purchase Intention (PI) and Purchase Behavior (PB). The Theory of Reasoned Action (TRA) was extended by adding Environmental Concern (EC) and Perceived Environmental Knowledge (PEK) as EA predictors. A total of 396 responses from Peru were analyzed through Partial Least Squares Structural Equation Modeling (PLS-SEM). In the findings, Environmental Attitude acts as a mediator between Environmental Concern and Perceived Environmental Knowledge, and Purchase Intention. Additionally, this actual interrelationship results in a positive relationship with Purchase Behavior. Subjective Norms were not an essential predictor of Purchase Intention, which validates previous studies. Our findings suggest that Peruvian consumers prefer sustainable clothing because they are concerned with and aware of current environmental issues. Consequently, their attitude is shaped based on environmental concern and perceived environmental knowledge, resulting in an increasing intention to buy sustainable clothes, which are aimed at reducing environmental impact. The research findings may support the marketing and selling strategies of firms to show that their brands are green and can generate more interest in current and future customers. The novelty is based on using the partial least squares structural equation modeling (PLS-SEM) technique.

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“…Vera-Nuñez et al carried out biosynthesis of a novel silver nanoparticle conjugated with Thelypteris glandulosolanosa (raqui-raqui) [ 140 ]. Silver nitrate (AgNO 3 ) was reduced and stabilized using raqui-raqui aqueous extract to form Ag nanoparticles (AgNPs-RR).…”

Section: Inhalable Formulationsmentioning

confidence: 99%

“…They were characterized using dynamic light scattering and scanning transmission electron microscopy and found to be spherical in shape with a mean hydrodynamic size equal to 39.16 nm. Upon carrying cell toxicity studies in A549 cells, the biosynthesized NP exhibited significant antitumor activity with an IC 50 value of 12.50 µg/mL [ 140 ].…”

Section: Inhalable Formulationsmentioning

confidence: 99%

Inhalable Formulations to Treat Non-Small Cell Lung Cancer (NSCLC): Recent Therapies and Developments

Gupta

2022

Pharmaceutics

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Cancer has been the leading cause of mortalities, with lung cancer contributing 18% to overall deaths. Non-small cell lung cancer (NSCLC) accounts for about 85% of all lung cancers. The primary form of therapy used to treat lung cancer still includes oral and systemic administration of drugs, radiotherapy, or chemotherapy. Some patients have to go through a regime of combination therapy. Despite being the only available form of therapy, their use is limited due to the adverse effects, toxicity, and development of resistance over prolonged use. This led to a shift and progressive evolution into using pulmonary drug delivery systems. Being a non-invasive method of drug-administration and allowing localized delivery of drugs to cancer cells, inhalable drug delivery systems can lead to lower dosing and fewer systemic toxicities over other conventional routes. In this way, we can increase the actual local concentration of the drug in lungs, which will ultimately lead to better antitumor therapy. Nano-based systems also provide additional diagnostic advantages during lung cancer treatment, including imaging, screening, and tracking. Regardless of the advantages, pulmonary delivery is still in the early stages of development and various factors such as pharmacology, immunology, and toxicology should be taken into consideration for the development of suitable inhalable nano-based chemotherapeutic drugs. They face numerous physiological barriers such as lung retention and efficacy, and could also lead to toxicity due to prolonged exposure. Nano-carriers with a sustained drug release mechanism could help in overcoming these challenges. This review article will focus on the various inhalable formulations for targeted drug delivery, including nano-based delivery systems such as lipids, liposome, polymeric and inorganic nanocarriers, micelles, microparticles and nanoaggregates for lung cancer treatment. Various devices used in pulmonary drug delivery loaded on various nano-carriers are also discussed in detail.

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Green Synthesis of a Novel Silver Nanoparticle Conjugated with Thelypteris glandulosolanosa (Raqui-Raqui): Preliminary Characterization and Anticancer Activity

Cited by 12 publications

References 154 publications

Design of Green Silver Nanoparticles Based on Primula Officinalis Extract for Textile Preservation

Design of Green Silver Nanoparticles Based on Primula Officinalis Extract for Textile Preservation

Sustainable Fashion and Consumption Patterns in Peru: An Environmental-Attitude-Intention-Behavior Analysis

Inhalable Formulations to Treat Non-Small Cell Lung Cancer (NSCLC): Recent Therapies and Developments

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