Green synthesis, characterization and determination of anti-prostate cancer, cytotoxicity and antioxidant effects of gold nanoparticles synthesized using Alhagi maurorum
“…The main reason is due to the presence of phytochemicals such as proteins, flavonoids, carbohydrates, and phenolic compounds to presence of –OH group. The high hydroxyl groups stabilized Ag NPs has responsible for potential antioxidant activity [ 45 , 46 ]. Fig.…”
“…The main reason is due to the presence of phytochemicals such as proteins, flavonoids, carbohydrates, and phenolic compounds to presence of –OH group. The high hydroxyl groups stabilized Ag NPs has responsible for potential antioxidant activity [ 45 , 46 ]. Fig.…”
“…AuNPs exhibited significant cytotoxicity and antiprostate carcinoma properties on various PC cell lines DU145, NCI-H660, 22Rv1, and LNCaP clone FGC, as shown by a dose-dependent reduction in cell viability following treatment. Moreover, this nanoformulation portrayed a promising antioxidant property against DPPH free radicals [124]. Similarly, Prema et al prepared green tea (GT)-AuNPs using Camellia sinensis L. extract that had a significant anti-proliferative effect on PC-3 cells.…”
Section: Modulations and Applications Of Green/ Biosynthesised Aunps ...mentioning
Green nanotechnology produces biocompatible gold nanoparticles (AuNPs) with intrinsic anti-microbial, anti-viral, and anti-tumour properties. Green AuNPs (g-AuNPs) are gaining a solid ground in prostate cancer (PC) nanotherapy. Hence, in this review, we summarise and compare data from studies published between 2015 and 2022 to highlight major biological compounds and outputs from in vitro and in vivo applications of green or biosynthesised AuNPs in PC theranostics. In fact, g-AuNPs can be easily generated with effective antiproliferative PC characteristics. Taken together, g-AuNPs exert various apoptosis-related mechanisms, such as reactive oxygen species (ROS) generation, cell cycle arrest, cytotoxicity, mitochondrial disruption, and anti-tumour immune cell activation, with additional successful delivery of the biological compounds in green materials. g-AuNPs could offer another modality for targeted cancer therapy using antibodies and targeting ligands to specifically recognise and destroy PC tumours. In conclusion, g-AuNPs applications drive forth sustainable nanotechnology while minimising ethical concerns and toxicity risks in clinical trials.
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