Green synthesis, characterization and antimicrobial activity of zinc oxide quantum dots using Eclipta alba

Singh, Akhilesh Kumar; Pal, Priti; Gupta, Vinay; Yadav, Thakur Prasad; Gupta, Vishu; Singh, Satarudra Prakash

doi:10.1016/j.matchemphys.2017.09.049

Cited by 107 publications

(41 citation statements)

References 45 publications

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“…Combinatorial materials used with ZnO NPs/MPs also showed antimicrobial activity using different mechanisms to overcome multi-drug resistance. These included antibiotic or anti-inflammatory drugs [ 20 , 47 , 79 ], other metal oxide NPs/MPs or metal doping [ 80 , 81 ], polymers (e.g., chitosan and alginate) [ 28 , 82 , 83 ], carbon-based materials (e.g., graphene [ 84 , 85 ], graphene oxide (GO) [ 86 , 87 ], and reduced graphene oxide (rGO) [ 88 ]), and quantum dots (QDs) [ 89 , 90 ]. They enhanced ROS generation or mediated the other antimicrobial pathways of ZnO NPs/MPs in microorganisms to create an additive or synergistic microbial growth inhibition benefit.…”

Section: Antimicrobial Ctivity Against Pathogenic Microorganismsmentioning

confidence: 99%

“…The lowest MIC levels among the ZnO QDs from ZnO-1 to ZnO-10 were as follows: ZnO QD-1, 25 mg/mL against E. coli ; ZnO QD-4 and ZnO QD-6, 25 mg/mL against E. aerogenes ; ZnO QD-3, and ZnO QD-5, 12.5 mg/mL against K. pneumonia ; ZnO QD-3 and ZnO QD-7, 12.5 mg/mL against P. aeruginosa ; ZnO QD-2, ZnO QD-3, and ZnO QD-8, 6.25 mg/mL against B. anthracis ; ZnO QD-8, 6.25 mg/mL against S. aureus ; ZnO QD-6 and ZnO QD-7, 50 mg/mL against L. monocytogenes ; ZnO QD-2 and ZnO QD-7, 25 mg/mL against E. faecalis ; ZnO QD-3 and ZnO QD-5, 12.5 mg/mL against B. cereus ; and ZnO QD-8, 1.5 mg/mL against S. epidermidis . Singh et al [ 90 ] reported spherical ZnO QDs of ~6 nm that showed an inhibition zone of 15.69 mm against E. coli . Compared to the growth inhibition level at 5 mM of bulk zinc acetate, that of ZnO QDs against E. coli increased by 1.6-fold.…”

Section: Antimicrobial Ctivity Against Pathogenic Microorganismsmentioning

confidence: 99%

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Antimicrobial Activity of Zinc Oxide Nano/Microparticles and Their Combinations against Pathogenic Microorganisms for Biomedical Applications: From Physicochemical Characteristics to Pharmacological Aspects

Jin

2021

Nanomaterials

124

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Zinc oxide (ZnO) nano/microparticles (NPs/MPs) have been studied as antibiotics to enhance antimicrobial activity against pathogenic bacteria and viruses with or without antibiotic resistance. They have unique physicochemical characteristics that can affect biological and toxicological responses in microorganisms. Metal ion release, particle adsorption, and reactive oxygen species generation are the main mechanisms underlying their antimicrobial action. In this review, we describe the physicochemical characteristics of ZnO NPs/MPs related to biological and toxicological effects and discuss the recent findings of the antimicrobial activity of ZnO NPs/MPs and their combinations with other materials against pathogenic microorganisms. Current biomedical applications of ZnO NPs/MPs and combinations with other materials are also presented. This review will provide the better understanding of ZnO NPs/MPs as antibiotic alternatives and aid in further development of antibiotic agents for industrial and clinical applications.

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Section: Antimicrobial Ctivity Against Pathogenic Microorganismsmentioning

confidence: 99%

Section: Antimicrobial Ctivity Against Pathogenic Microorganismsmentioning

confidence: 99%

Antimicrobial Activity of Zinc Oxide Nano/Microparticles and Their Combinations against Pathogenic Microorganisms for Biomedical Applications: From Physicochemical Characteristics to Pharmacological Aspects

Jin

2021

Nanomaterials

124

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“…QDs possess outstanding physio-chemical features as a result of the quantum confinement effect [ 46 ]. When material′s size is reduced, the quantum size features become prominent [ 47 ]. When the radius of nanoparticles is under the Bohr limit of excitation, the charge carrier′s Bohr radius becomes greater than that of the sphere.…”

Section: Physicochemical Properties Of Qdsmentioning

confidence: 99%

Superior Properties and Biomedical Applications of Microorganism-Derived Fluorescent Quantum Dots

et al. 2020

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Quantum dots (QDs) are fluorescent nanocrystals with superb photo-physical properties. Applications of QDs have been exponentially increased during the past decade. They can be employed in several disciplines, including biological, optical, biomedical, engineering, and energy applications. This review highlights the structural composition and distinctive features of QDs, such as resistance to photo-bleaching, wide range of excitations, and size-dependent light emission features. Physical and chemical preparation of QDs have prominent downsides, including high costs, regeneration of hazardous byproducts, and use of external noxious chemicals for capping and stabilization purposes. To eliminate the demerits of these methods, an emphasis on the latest progress of microbial synthesis of QDs by bacteria, yeast, and fungi is introduced. Some of the biomedical applications of QDs are overviewed as well, such as tumor and microRNA detection, drug delivery, photodynamic therapy, and microbial labeling. Challenges facing the microbial fabrication of QDs are discussed with the future prospects to fully maximize the yield of QDs by elucidating the key enzymes intermediating the nucleation and growth of QDs. Exploration of the distribution and mode of action of QDs is required to promote their biomedical applications.

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“…On the other hand, used de novo designed amino acid domains to fuel the development of the coiled-coil scaffolds that present the antigenic epitopes on the nanoparticles surface [66]. As the surface area of the nanoparticles increases with the reduction of particles size, therefore there is a great need to develop more in silico strategy for effective nanovaccine designs that fulfil the vaccine requirement of needy human being [67].…”

Section: Population Coverage Analysis and Selection Of Minimal Epitopmentioning

confidence: 99%

Exploitation of reverse vaccinology and immunoinformatics as promising platform for genome-wide screening of new effective vaccine candidates against Plasmodium falciparum

et al. 2019

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Background: In the current scenario, designing of world-wide effective malaria vaccine against Plasmodium falciparum remain challenging despite the significant progress has been made in last few decades. Conventional vaccinology (isolate, inactivate and inject) approaches are time consuming, laborious and expensive; therefore, the use of computational vaccinology tools are imperative, which can facilitate the design of new and promising vaccine candidates. Results: In current investigation, initially 5548 proteins of P. falciparum genome were carefully chosen for the incidence of signal peptide/ anchor using SignalP4.0 tool that resulted into 640 surface linked proteins (SLP). Out of these SLP, only 17 were predicted to contain GPI-anchors using PredGPI tool in which further 5 proteins were considered as malarial antigenic adhesins by MAAP and VaxiJen programs, respectively. In the subsequent step, T cell epitopes of 5 genome derived predicted antigenic adhesins (GDPAA) and 5 randomly selected known malarial adhesins (RSKMA) were analysed employing MHC class I and II tools of IEDB analysis resource. Finally, VaxiJen scored T cell epitopes from each antigen were considered for prediction of population coverage (PPC) analysis in the world-wide population including malaria endemic regions. The validation of the present in silico strategy was carried out by comparing the PPC of combined (MHC class I and II) predicted epitope ensemble among GDPAA (99.97%), RSKMA (99.90%) and experimentally known epitopes (EKE) of P. falciparum (97.72%) pertaining to world-wide human population. Conclusions:The present study systematically screened 5 potential protective antigens from P. falciparum genome using bioinformatics tools. Interestingly, these GDPAA, RSKMA and EKE of P. falciparum epitope ensembles forecasted to contain highly promiscuous T cell epitopes, which are potentially effective for most of the world-wide human population with malaria endemic regions. Therefore, these epitope ensembles could be considered in near future for novel and significantly effective vaccine candidate against malaria.

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Green synthesis, characterization and antimicrobial activity of zinc oxide quantum dots using Eclipta alba

Cited by 107 publications

References 45 publications

Antimicrobial Activity of Zinc Oxide Nano/Microparticles and Their Combinations against Pathogenic Microorganisms for Biomedical Applications: From Physicochemical Characteristics to Pharmacological Aspects

Antimicrobial Activity of Zinc Oxide Nano/Microparticles and Their Combinations against Pathogenic Microorganisms for Biomedical Applications: From Physicochemical Characteristics to Pharmacological Aspects

Superior Properties and Biomedical Applications of Microorganism-Derived Fluorescent Quantum Dots

Exploitation of reverse vaccinology and immunoinformatics as promising platform for genome-wide screening of new effective vaccine candidates against Plasmodium falciparum

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