Green, Rapid, Simple, and an Effective One-Pot Multicomponent Strategy for Synthesis of Novel Dihydropyrano[2,3-C]pyrazol-6-Amines in Aqueous Medium

Abstract

Objectives: A series of new dihydropyrano [2,3-c]pyrazol-6-amines in this investigation study, are synthesized by the strategy of one-pot four component reaction in an aqueous medium.
 Methods: After getting optimum conditions the reaction of different substituted aromatic aldehydes, ethyl acetoacetate, hydrazine hydrate, and phenylacetonitrile catalysed by Sodium hydrogen sulphate NaHSO4 (0.5 m mol) by refluxing in ethanol-water (1:1) (5 ml) and heated at 80 oC. The synthesized molecules product was filtered, washed with water to get nearly pure product in excellent yield.
 Results: The pure products which were got in a short duration, with excellent yield (80 – 87%). Those new compounds were identified by using spectroscopic techniques FT-IR, 1H-NMR and 13C-NMR.
 Conclusion: In conclusion, the usefulness of this one-pot multicomponents protocol include easily available starting materials, facile, simple and environment-friendly procedure, and easier separation of products by filtration.
 Peer Review History: 
 Received 5 March 2019; Revised 11 April; Accepted 9 May, Available online 15 May 2020
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 Received file 
 
 Average Peer review marks at initial stage: 5.0/10
 Average Peer review marks at publication stage: 7.0/10
 Reviewer(s) detail:
 Name: Prof Cyprian Ogbonna ONYEJI
 Affiliation: Obafemi Awolowo University, Ile-Ife, Nigeria
 E-mail: conyeji@oauife.edu.ng
 
 Name: Dr. Md. Shahidul Islam
 Affiliation: USTC, Chittagong, Bangladesh
 E-mail: S_i_liton@yahoo.com
 Comments of reviewer(s): 
 
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