Green preparation of carbon dots from plum as a ratiometric fluorescent probe for detection of doxorubicin

Zhu, Jiantao; Chu, Huiyuan; Shen, Jiwei; Wang, Chaozhan; Wei, Yinmao

doi:10.1016/j.optmat.2021.110941

Cited by 39 publications

(26 citation statements)

References 35 publications

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“…The dual-emitted property at the wavelengths of 491 nm and 591 nm provided a ratiometric calibration curve as a function of the DOX concentration. They also confirmed the accuracy by analyzing urine and serum samples (Figure 8b) [27]. CDs are suitable for detecting different kinds of molecules and ions.…”

Section: Sensorssupporting

confidence: 57%

“…As for drug probing, Zhu et al analyzed doxorubicin (DOX), an anthracycline-based anticancer medicine, by taking advantage of the PL of plum-based carbon quantum dots (PCQDs).The dual-emitted property at the wavelengths of 491 nm and 591 nm provided a ratiometric calibration curve as a function of the DOX concentration. They also confirmed the accuracy by analyzing urine and serum samples (Figure8b)[27]. CDs are suitable for detecting different kinds of molecules and ions.…”

supporting

confidence: 58%

“…In this section, we compare bioimaging from cells to living animals, emphasizing the biological diversity to prove the generalized safety of CDs. In cell imaging applications, CDs are usually applied to HepG2 cells, HeLa cells, T24 cells, and so on [27,102,120,124]. In addition, normal cell lines have been used in trials, showing good cell compatibility [24,71].…”

Section: Bioimagingmentioning

confidence: 99%

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Natural Carbon Nanodots: Toxicity Assessment and Theranostic Biological Application

et al. 2021

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This review outlines the methods for preparing carbon dots (CDs) from various natural resources to select the process to produce CDs with the best biological application efficacy. The oxidative activity of CDs mainly involves photo-induced cell damage and the destruction of biofilm matrices through the production of reactive oxygen species (ROS), thereby causing cell auto-apoptosis. Recent research has found that CDs derived from organic carbon sources can treat cancer cells as effectively as conventional drugs without causing damage to normal cells. CDs obtained by heating a natural carbon source inherit properties similar to the carbon source from which they are derived. Importantly, these characteristics can be exploited to perform non-invasive targeted therapy on human cancers, avoiding the harm caused to the human body by conventional treatments. CDs are attractive for large-scale clinical applications. Water, herbs, plants, and probiotics are ideal carbon-containing sources that can be used to synthesize therapeutic and diagnostic CDs that have become the focus of attention due to their excellent light stability, fluorescence, good biocompatibility, and low toxicity. They can be applied as biosensors, bioimaging, diagnosis, and treatment applications. These advantages make CDs attractive for large-scale clinical application, providing new technologies and methods for disease occurrence, diagnosis, and treatment research.

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Section: Sensorssupporting

confidence: 57%

supporting

confidence: 58%

Section: Bioimagingmentioning

confidence: 99%

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Natural Carbon Nanodots: Toxicity Assessment and Theranostic Biological Application

et al. 2021

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“…The obtained carbon dots (BNS-CDs) by Liu et al can be used to detect Fe 3+ via a fluorescent and colorimetric dual-mode method. However, there are few probes based on the CDs to detect DOX. − Only few researches in this area can be found. Min et al synthesized polyethyleneimine-functionalized carbon dots (PEI-CDs) for the detection of DOX based on the inner filter effect.…”

Section: Introductionmentioning

confidence: 99%

11-Mercaptoundecanoic Acid-Functionalized Carbon Dots As a Ratiometric Optical Probe for Doxorubicin Detection

Zhang

Xing²,

Liu³

et al. 2021

ACS Appl. Nano Mater.

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A ratiometric optical dual-mode probe was first designed for the detection of doxorubicin (DOX) based on 11-mercaptoundecanoic acid-functionalized carbon dots (MUA-CDs). The carbon dots (CDs) were synthesized via hydrothermal carbonization of m-phenylenediamine and p-aminobenzoic acid, and then it was reacted with 11-mercaptoundecanoic acid by the amide reaction to obtain the MUA-CDs. The as-synthesized MUA-CDs have a high fluorescence quantum yield (59.4%) with bright green emission. Based on a specific electrostatic interaction and the fluorescence resonance energy transfer (FRET) between MUA-CDs and DOX, a ratiometric optical dual-mode probe was constructed for the detection of DOX with good selectivity, high sensitivity, and excellent anti-interference performance. When DOX was mixed the MUA-CDs, the fluorescence of the MUA-CDs at 513 nm decreased, while the fluorescence at 590 nm increased. With this information, a ratiometric fluorescent method was established to determine DOX with a linear range and limit of detection (LOD) of 0.25–19.96 and 0.66 μM and 50.33–80.88 and 0.23 μM, respectively. Meanwhile, the color of the MUA-CDs varied from colorless to dark yellow in the presence of DOX, and therefore, a ratiometric colorimetric method was applied to determine DOX in a range of 2.50–29.80 μM with a LOD of 0.75 μM. Finally, the as-constructed probe was successfully used to determine DOX in serum, urine, and live cells with satisfactory results. This work will contribute to the specific design of functional CDs and broaden the application of functional CDs in analytical detection and biological imaging.

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“…Carbon dots (CD) is a novel kind of the quantum-sized nanomaterials, which have enormous application potential in bio-imaging, drug carrier, and nanosystems [16][17][18]. Carbon dots are composed by carbon atoms, exhibiting excellent inherent biocompatibility, have the feasibility in the biotechnology application [19][20][21][22]. CD have the capability of delivery chemotherapeutic to the tumor, decrease cytotoxicity, and enhance chemotherapy e cacy [23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Doxorubicin and siRNA co-delivery System Based on Carbon Dots Inhibits Chemoresistance of Lung Cancer Through MRP1

Luo

Tang²,

Lin³

et al. 2021

Preprint

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BackgroundAcquired resistance against chemotherapeutic drugs hinders the clinical efficacy of treatments in lung cancer. To circumvent the developed resistance, we aim to target critical signaling molecules related with chemoresistance through co-delivering siRNA and chemotherapeutics. The co-delivery strategy may address the unmet need to efficiently counteracting the multidrug resistance in treating lung cancer. MethodsA co-delivery nanosystem that could carry siRNA and DOX simultaneously has been studied in this work. The co-delivery is based on carbon dots was surface-modified with poly-ethylenimine (PEI), and loaded the siMRP1 and chemotherapeutics on the surface with pH-triggered drug release. The CD-PEI was synthesized by one-step microwave assisted method; the PEI were raw materials and passivator during the reaction process that makes CD exhibit excellent optical property.ResultsThe CD-PEI was capable of loading and delivering siMRP1 and DOX to tumor and release synchronously in cells by acid-triggered manner.The expression of MRP1 in A549 and A549/ADM cells were successfully knocked down by siRNA. The silencing of MRP1 by co-delivery system could increase DOX accumulation and significantly enhance the inhibitory effect of cell viability. Moreover, the co-delivery system enhances the inhibitory effect of metastatic potential elicited by doxorubicin in A549 and A549/ADM cells.ConclusionBy suppressing MRP1, the co-delivery system can obviously increase the drug cellular accumulation and inhibit the cell proliferation, migration and invasion of lung cancer, implying its potential application to overcome chemoresistance and enhance therapeutic efficiency in clinical practices.

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Green preparation of carbon dots from plum as a ratiometric fluorescent probe for detection of doxorubicin

Cited by 39 publications

References 35 publications

Natural Carbon Nanodots: Toxicity Assessment and Theranostic Biological Application

Natural Carbon Nanodots: Toxicity Assessment and Theranostic Biological Application

11-Mercaptoundecanoic Acid-Functionalized Carbon Dots As a Ratiometric Optical Probe for Doxorubicin Detection

Doxorubicin and siRNA co-delivery System Based on Carbon Dots Inhibits Chemoresistance of Lung Cancer Through MRP1

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