Green Polymers toward Nanobiotechnology(I): Synthesis of Glycopolypeptides and Their Analogues

Abstract

Harnessing natural-based renewable molecular resources to construct functional synthetic green polymers is a promising research frontier at the interface of sustainable/green chemistry, polymer chemistry and nanobiotechnology. As natural glycoprotein mimics/analogues and biocompatible building blocks of nanobiomaterials, synthetic functional glycopolypeptides and their structural/functional analogues have attracted great attentions in recent years. This mini-perspective article reviewed current synthetic strategies and methods of glycopolypeptides and their analogues. The pros and cons of the synthesis protocols were discussed, moreover, possible future perspectives in this field were also stated.

Prodrug Systems (II): A Perspective of Polymer-Based Doxorubicin Prodrug Systems towards Chemotherapy

“…For the future outlook of polymer-based doxorubicin prodrug chemotherapeutic systems, we can expect the research and development (R & D) in the following areas: (1) using natural-based sustainable resources, [25] such as: polysaccharides, polypeptides/peptoids and polylipids/lipoids, along with green, efficient, controllable and modular methods/ strategies to synthesize natural polymer-based doxorubicin prodrugs/conjugates; (2) expanding the structure/function diversity of the polymer-based doxorubicin prodrugs, especially "smart" (stimuli-responsive, multifunction-integrated, receptor targeting, bio-recognition, etc.) polymer-based doxorubicin prodrugs towards precision and personalized medicine; especially, it is worth integrating polymer-doxorubicin prodrugs with 18 F, 64 Cu-based positron electron tomography (PET) system or functional inorganic nanoparticles [26] for creating efficient multi-channel prodrug-based theranostics; (3) Elucidating the structure-function relationship (SFR) between the architectures of polymer-based doxorubicin prodrugs/ conjugates and their physicochemical/biological functions; (4) Based on in vitro bioevaluation data, optimizing the (natural) polymer-based doxorubicin prodrugs and their nanodelivery systems for programmable/synergistic theranostic performance;…”