Green Nano‐Biotechnology: A New Sustainable Paradigm to Control Dengue Infection

Abstract

Dengue is a growing mosquito-borne viral disease prevalent in 128 countries, while 3.9 billion people are at high risk of acquiring the infection. With no specific treatment available, the only way to mitigate the risk of dengue infection is through controlling of vector, i.e., Aedes aegypti. Nanotechnology-based prevention strategies like biopesticides with nanoformulation are now getting popular for preventing dengue fever. Metal nanoparticles (NPs) synthesized by an eco-friendly process, through extracts of medicinal plants have indicated potential anti-dengue applications. Green synthesis of metal NPs is simple, cost-effective, and devoid of hazardous wastes. The recent progress in the phyto-synthesized multifunctional metal NPs for anti-dengue applications has encouraged us to review the available literature and mechanistic aspects of the dengue control using green-synthesized NPs. Furthermore, the molecular bases of the viral inhibition through NPs and the nontarget impacts or hazards with reference to the environmental integrity are discussed in depth. Till date, major focus has been on green synthesis of silver and gold NPs, which need further extension to other innovative composite nanomaterials. Further detailed mechanistic studies are required to critically evaluate the mechanistic insights during the synthesis of the biogenic NPs. Likewise, detailed analysis of the toxicological aspects of NPs and their long-term impact in the environment should be critically assessed.

Applications of Green Synthesized Metal Nanoparticles — a Review

“…The silver nanoparticle is considered to be a successful and novel pharmacological agent that regulates efficient antiviral activity against Influenza virus, Human parainfluenza virus type 3, Chikungunya virus, Herpes simplex virus, Norovirus, bovine Herpes virus, Dengue virus, Adenovirus, feline coronavirus (FCoV), and HIV [55, [190][191][192][193][194][195][196][197][198][199]. The silver nanoparticle was used to suppress antiviral effects in a dose-dependent manner by in vitro methods.…”

Current Knowledge, Research Progress, and Future Prospects of Phyto-Synthesized Nanoparticles Interactions with Food Crops under Induced Drought Stress

“…In recent research, there has been a growing interest in exploring the potential impacts of using phyto-synthesized NPs as an innovative and biodegradable approach to understanding various aspects of plant physiology. This approach becomes particularly relevant when addressing ecological challenges such as water scarcity [323,324]. One particularly dynamic aspect that has garnered considerable attention is the influence of phyto-synthesized NPs on water-related processes within plants.…”

“…As a result, the plant can better manage water scarcity and endure adverse environmental circumstances. A fascinating area of study is the relationship between phyto-synthesized NPs and JA signaling, which has the potential to lead to the development of brand-new, ground-breaking techniques for improving drought tolerance in plants and advancing environmentally friendly farming methods, as shown in Figure 3 [324,351].…”

Biogenic Selenium Nanoparticles: Anticancer, Antimicrobial, Insecticidal Properties and Their Impact on Soybean (Glycine max L.) Seed Germination and Seedling Growth

“…Nanotechnology is one of the more recent inter-disciplinary fields that has made significant contributions to a variety of applications [6]. Nanobiotechnology is a subfield of nanotechnology concerned with the production and manipulation of nanoparticles using living organisms [7]. Microbial synthesis of nanoparticles is regarded as an eco-friendly method that can aid in sustainable synthesis and is economically viable, which supports the increasing use of nanoparticles in a variety of applications [4].…”