Green formulation and chemical characterizations of Rhamnella gilgitica aqueous leaves extract conjugated NiONPs and their multiple therapeutic properties

Abbasi, Banzeer Ahsan; Iqbal, Javed; Kiran, Farmeen; Ahmad, Riaz; Kanwal, Sobia; Munir, Akhtar; Uddin, Siraj; Nasir, Jamal Abdul; Chalgham, Wadie; Mahmood, Tariq

doi:10.1016/j.molstruc.2020.128490

Cited by 34 publications

(34 citation statements)

References 33 publications

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“…Plant-mediated green synthesis is getting significant value in biomedical fields due to its simplicity, easy availability, ecofriendly nature and nontoxicity, and it eradicates the prerequisite of reducing agents and energy from the external environment. Studies show that plants contain numerous valuable bioactive compounds like alkaloids, polyphenols, flavonoids, terpenoids, vitamins and minerals, which play a vital role as stabilising, capping and reducing agents during phytofabrication of NPs [ 5 ]. These phytochemicals also have significant antioxidant, anti-microbial, anti-inflammatory, chemo-preventative and cytotoxic potentials [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of Nickel Oxide Nanoparticles from Berberis balochistanica Stem for Investigating Bioactivities

et al. 2021

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Green synthesis of nanomaterials is advancing due to its ease of synthesis, inexpensiveness, nontoxicity and renewability. In the present study, an eco-friendly biogenic method was developed for the green synthesis of nickel oxide nanoparticles (NiONPs) using phytochemically rich Berberis balochistanica stem (BBS) extract. The BBS extract was rich in phenolics, flavonoids and berberine. These phytochemicals successfully reduced and stabilised the NiNO3 (green) into NiONPs (greenish-gray). BBS-NiONPs were confirmed by using UV-visible spectroscopy (peak at 305 nm), X-ray diffraction (size of 31.44 nm), Fourier transform infrared spectroscopy (identified -OH group and Ni-O formation), energy dispersive spectroscopy (showed specified elemental nature) and scanning electron microscopy (showed rhombohedral agglomerated shape). BBS-NiONPs were exposed to multiple in vitro bioactivities to ascertain their beneficial biological applications. They exhibited strong antioxidant activities: total antioxidant capacity (64.77%) and 2, 2-diphenyl-1-picrylhydrazyl (71.48%); and cytotoxic potential: Brine shrimp cytotoxicity assay with IC50 (10.40 µg/mL). BBS-NiONPs restricted the bacterial and fungal pathogenic growths at 1000, 500 and 100 µg/mL. Additionally, BBS-NiONPs showed stimulatory efficacy by enhancing seed germination rate and seedling growth at 31.25 and 62.5 µg/mL. In aggregate, BBS extract has a potent antioxidant activity which makes the green biosynthesis of NiONPs easy, economical and safe. The biochemical potential of BBS-NiONPs can be useful in various biomedical and agricultural fields.

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Section: Introductionmentioning

confidence: 99%

Green Synthesis of Nickel Oxide Nanoparticles from Berberis balochistanica Stem for Investigating Bioactivities

et al. 2021

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“…IR spectra (KBr discs) were measured using a FTIR plus 460 or PyeUnicam SP-1000 spectrophotometer. 1…”

Section: 1generalmentioning

confidence: 99%

“…were measured using a FTIR plus 460 or PyeUnicam SP-1000 spectrophotometer. 1 HNMR spectra were measured using Varian Gemini-200 (200 MHz) and Jeol AS 500 MHz instruments spectra were performed in DMSO-d6 as solvent using TMS as internal standard and chemical shifts are expressed as δ ppm. MS (EI) spectra were measured using Hewlett Packard 5988 A GC/MS system and GCMS-QP 1000 Ex Shimadzu instruments.…”

Section: 1generalmentioning

confidence: 99%

“…Medicinal chemistry had its beginning when chemists, pharmacist and physicians isolated and purified active principles of plants and animals' tissues and taken from microorganism and their fermentation products. Some of these chemicals has been associated with therapeutic properties: Medicinal chemistry which has leaned on the classical fields of chemistry, especially organic chemistry, biology and some area of physics [1][2][3][4][5][6][7][8]. A limited number of natural and synthetic products and serve directly as therapeutic agents although lack of specificity frequently limits their application in human and veterinary medicines and in analogous pesticidal and other uses in agriculture [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

“…Heterocycles are widely investigated for possible medicinal applications [28,29]. Favipiravir (1) [30], amodiaquine (2) [31], 20-fluoro-20-deoxycytidine (3) [32], and (4) [33] are known as antiviral drugs. In biological systems, the halogenation of organic molecules is catalyzed by enzymes haloperoxidases such as MPO, EPO and LPO in normal physiological processes, which combine the inorganic substrates Xand H2O2 to produce RHS.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis of Novel Halogenated Heterocyclic compounds and their uses as Target SARS-CoV-2 main Protease (Mpro) and Potential Anti-Covid-19

Mohareb

Almutairi²,

Elfiky³

et al. 2021

Preprint

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Since the first appearance of the coronavirus disease-2019 (COVID-19) in Wuhan, China, in December 2019, it has been spreading globally with devastating ramifications. The lack of anti-COVID-19 treatment to date warrants urgent research into potential therapeutic targets. Virtual drug screening techniques enable the identification of novel compounds that are capable of targeting the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro). The latter plays a fundamental role in mediating viral replication and transcription, rendering it an attractive drug target. In this study, twenty six novel halogenated, heterocyclic compounds, which can inhibit Mpro, were tested by molecular docking combined with molecular dynamics simulation. Three compounds showed the highest binding affinity to the protein active site and their binding modes coincide with that of Nelfinavir. The binding of the halogenated compounds to Mpro may inhibit the replication and transcription of SARS-CoV-2 and, ultimately, stop the virallife cycle. In times of dire need for anti-COVID-19 treatment, this study lays the groundwork for further experimental research to investigate the efficacy and potential medical uses of these compounds to treat COVID-19. Novel compounds including fused thiophene, pyrimidine and pyran derivatives were tested against human RNA N7-MTase (hRNMT) and selected viral N7-MTases such as SARS-CoV nsp14 and Vaccinia D1-D12 complex to evaluate their specificity and their molecular modeling was also studied in the aim of producing anti covid-19 target molecules.

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Antimicrobial, cytotoxic, antioxidants, enzyme inhibition activities, and scanning electron microscopy of Lactuca orientalis (Boiss.) Boiss. seeds

Zahra

Iqbal

Abbasi

et al. 2021

Microscopy Res & Technique

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Lactuca orientalis (Boiss.) Boiss. is one of the most frequently used ethnomedicinal plant. This research study was designed to decipher the phytochemical screening, pharmacological potential and implementation of scanning electron microscope (SEM). Six different solvents were used to prepare L. orientalis (LO) seed extracts.Phytochemical and antioxidant activities were determined calorimetrically. To investigate antidiabetic, α-amylase inhibition assay was performed. Brine shrimp assay was performed for cytotoxicity and anti-leishmanial via MTT assay. Disc-diffusion assay was performed to detect protein kinase inhibitory, antibacterial and antifungal activities. SEM was used as identification tool. Significant amount of phenolic and flavonoid content were identified in methanol extract (LOSM) (95.76 ± 3.71 GAE/mg) and (77 ± 3.60 QE/mg). Highest DPPH scavenging potential (82%) was reported for LOSM. Significant total antioxidant capacity (90.60 ± 1.55 AAE/mg) and total reducing power (94.44 ± 1.38 AAE/mg) were determined for LOSM. Highest α-amylase inhibition was found in LOSM (78.20 ± 1.58%). The highest LD 50 of brine shrimp was found for n-Hexane extract (LOSH) 13.03 μg/ml. All extracts showed strong antileishmanial activity except LOSH. L. orientalis seeds showed significant protein kinase inhibition, antibacterial and antifungal activities. The seeds of L. orientalis were seen to be oblong to obovate, projections, wavy slightly straight, anticlinal wall was raised with apex acuminate. The outer-periclinal wall convex with fine texture. In conclusion, our findings scientifically support ethnomedicinal and biological potentials of L. orientalis seeds. In future, L. orientalis seeds need to be explored for identification and isolation of bioactive compounds. The results obtained necessitate further in vivo studies to evaluate their pharmacological potentials. Key points• An extensive phytochemical potential study on the seeds of novel medicinal plant Lactuca orientalis (Boiss.) Boiss. was reported.• Scanning electron microscopy was used as an identification tool and reported for the first time for seeds of L. orientalis.

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Green formulation and chemical characterizations of Rhamnella gilgitica aqueous leaves extract conjugated NiONPs and their multiple therapeutic properties

Cited by 34 publications

References 33 publications

Green Synthesis of Nickel Oxide Nanoparticles from Berberis balochistanica Stem for Investigating Bioactivities

Green Synthesis of Nickel Oxide Nanoparticles from Berberis balochistanica Stem for Investigating Bioactivities

Synthesis of Novel Halogenated Heterocyclic compounds and their uses as Target SARS-CoV-2 main Protease (Mpro) and Potential Anti-Covid-19

Antimicrobial, cytotoxic, antioxidants, enzyme inhibition activities, and scanning electron microscopy of Lactuca orientalis (Boiss.) Boiss. seeds

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